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Diabetes Mellitus- Part 2
See all quizzes of Diabetes Mellitus at here:
Diabetes Mellitus- Part 1|Diabetes Mellitus- Part 2|Diabetes Mellitus- Part 3|Diabetes Mellitus- Part 4|Diabetes Mellitus- Part 5|Diabetes Mellitus- Part 6|Diabetes Mellitus- Part 7
1.Frederick G. Banting, who discovered insulin was a ?
A. Physiologist
B. Biochemist
C. Orthopedic surgeon
D. Physician
2. Glucose is transported into the pancreatic cells via ?
A. GLUT 1
B. GLUT 2
C. GLUT 3
D. GLUT 4
3. Which of the following acts as a rate-limiting step that controls
glucose-regulated insulin secretion ?
A. Pyruvate
B. Glucose-6-phosphate
C. Glucokinase
D. All of the above
4. Beta cell membrane depolarization that stimulates insulin secretion
by opening calcium channels is done by ?
A. Stimulation of ATP-sensitive K+ channel
B. Inhibition of ATP-sensitive K+ channel
C. Stimulation of ATP-sensitive Ca++ channel
D. Inhibition of ATP-sensitive Ca++ channel
5. What proportion of insulin in portal system is degraded by the
liver ?
A. 10 %
B. 25 %
C. 50 %
D. 75 %
6. Which of the following glucose transporters is crucial for glucose
uptake by skeletal muscle and fat ?
A. GLUT 1
B. GLUT 2
C. GLUT 3
D. GLUT 4
7. “SUR” stands for ?
A. Sugar receptor
B. Sulfonylurea receptor
C. Sucrose receptor
D. Sulphar receptor
8. Major portion of postprandial glucose is utilized by ?
A. Skeletal muscle
B. Liver
C. Adipose tissue
D. Brain
9. Which of the following is false about insulin secretion ?
A. Secreted in a pulsatile pattern
B. Meals induce large bursts of insulin secretion
C. About 50% of secreted insulin is degraded by liver
D. None of the above
10. All of the following are involved in insulin signal transduction in
skeletal muscles except ?
A. IRS proteins
B. Shc proteins
C. PI-3-kinase
D. PAX-3
11. Destruction of pancreatic beta cells in Type 1A DM develops as a
result of which of the following ?
A. Genetic factors
B. Environmental factors
C. Immunologic factors
12. What percentage of beta cell mass is destroyed when type 1
diabetes results ?
A. 40 %
B. 60 %
C. 80 %
D. 100 %
13. In relation to type 1A DM, honeymoon period is ?
A. Increased insulin requirement after marriage
B. Glycemic control achieved by OHA
C. Insulin requirement is nil or modest
D. Weight gain after insulin treatment
14. Major susceptibility gene for type 1 DM is on chromosome ?
A. 1
B. 5
C. 6
D. 12
15. Concordance of type 1A DM in identical twins ranges between ?
A. 10 and 40%
B. 20 and 50%
C. 40 and 60%
D. 50 and 90%
16. Glucagon is produced by ?
A. Alpha cells
B. Beta cells
C. Delta cells
D. PP cells
17. Somatostatin is produced by ?
A. Alpha cells
B. Beta cells
C. Delta cells
D. PP cells
18. Which of the following islet cell type is spared from the autoimmune
process ?
A. Alpha cells
B. Delta cells
C. PP cells
D. All of the above
19. In type 1A DM, after all beta cells are destroyed, which of the
following statements is false ?
A. Inflammatory process abates
B. Islets become atrophic
C. Immunologic markers disappear
D. None of the above
20. In pathogenesis of type 1 DM, all of the following are true
except ?
A. Pancreatic islets are infiltrated by lymphocytes
B. All islet cell types are involved
C. Release of TNF & IL-1 play a role
D. Direct CD8+ mediated cytotoxicity
21. In pathogenesis of type 1 DM, islet destruction is mediated by ?
A. T lymphocytes
B. B lymphocytes
C. Eosinophils
D. Neutrophils
22. Pancreatic islet molecules targeted in autoimmune process in
type 1A DM are all except ?
A. Insulin
B. Glutamic acid decarboxylase (GAD)
C. Integrin
D. ZnT-8
23.Which of the following autoantigens is not found is type I DM ?
A. GAD-65
B. GLUR
C. IA-2 / ICA-512
D. Insulin
.
24. Haplotypes most strongly associated with type 1 DM include all
except ?
A. DQA1*0301
B. DQA1*0102
C. DQB1*0302
D. DQB1*0201
25.The strongest single association with type 1 DM is with which
haplotype ?
A. DQB1*0202
B. DQB1*0302
C. DQB1*0402
D. DQB1*0602
