The quizzes about Cerebrospinal Fluid

Select the one best response to each question!

The functions of the CSF include all of the following except:

Removal of metabolic wastes

Producing an ultrafiltrate of plasma

Supplying nutrients to the CNS

Protection of the brain and spinal cord

Correct! Wrong!

The CSF flows through the:

Choroid plexus

Pia mater

Arachnoid space

Dura mater

Correct! Wrong!

Substances present in the CSF are contolled by the:

Arachnoid granulations

Blood-brain barrier

Presence of one-way valves

Blood-CSF barrier

Correct! Wrong!

The CSF tube labeled 3 is sent to:

The hematology department

The chemistry department

The microbiology department

The serology department

Correct! Wrong!

The CSF tube that should be refrigerated is:

Tube 1

Tube 2

Tube 3

Tube 4

Correct! Wrong!

The presence of xanthochromia can be caused by all of the following except:

Immature liver function

RBC degradation

A recent hemorrhage

Elevated CSF protein

Correct! Wrong!

A web-like pellicle in a refrigerated CSF specimen is indicative of:

Tubercular meningitis

Multiple sclerosis

Primary CNS malignancy

Viral meningitis

Correct! Wrong!

Given the following information, calculate the CSF WBC count: cells counted, 80; dilution, 1:10; large Neubauer squares counted, 10.

800

8000

Correct! Wrong!

A CSF WBC count is diluted with:

Distilled water

Normal saline

Acetic acid

Methylene blue

Correct! Wrong!

A total CSF cell count on a clear fluid should be:

Reported as normal

Not reported

Diluted with normal saline

Counted undiluted

Correct! Wrong!

The purpose of adding albumin to CSF before cytocentrifugation is to:

Increase the cell yield

Decrease the cellular distortion

Improve the cellular staining

Both A and B

Correct! Wrong!

The primary concern when pleocytosis of neutrophils and lymphocytes is found in the CSF is:

Meningitis

CNS malignancy

Multiple sclerosis

Hemorrhage

Correct! Wrong!

Neutrophils with pyknotic nuclei may be mistaken for:

Lymphocytes

Nucleated RBCs

Malignant cells

Spindle-shaped cells

Correct! Wrong!

The presence of which of the following cells is increased when a CNS shunt malfunctions?

Neutrophils

Macrophages

Eosinophils

Lymphocytes

Correct! Wrong!

Macrophages appear in the CSF following:

Hemorrhage

Repeated spinal taps

Diagnostic procedures

All of the above

Correct! Wrong!

Nucleated RBCs are seen in the CSF as a result of:

Elevated blood RBCs

Treatment of anemia

Severe hemorrhage

Bone marrow contamination

Correct! Wrong!

Following a CNS diagnostic procedure, which of the following might be seen in the CSF?

Choroidal cells

Ependymal cells

Spindle-shaped cells

All of the above

Correct! Wrong!

Hemosiderin granules and hematoidin crystals are seen in:

Lymphocytes

Macrophages

Ependymal cells

Neutrophils

Correct! Wrong!

Myeloblasts are seen in the CSF:

In bacterial infections

In conjunction with CNS malignancy

Following cerebral hemorrhage

As a complication of acute leukemia

Correct! Wrong!

Cells resembling large and small lymphocytes with cleaved nuclei represent:

Lymphoma cells

Choroid cells

Choroid cells Melanoma cells

Medulloblastoma cells

Correct! Wrong!

The normal value of CSF protein is:

6–8 g/dL

15–45 g/dL

6–8 mg/dL

15–45 mg/dL

Correct! Wrong!

CSF can be differentiated from plasma by the presence of:

Albumin

Globulin

Prealbumin

Tau transferrin

Correct! Wrong!

In plasma, the second most prevalent protein is IgG; in CSF, the second most prevalent protein is:

Transferrin

Prealbumin

IgA

Ceruloplasmin

Correct! Wrong!

Elevated CSF protein values can be caused by all of the following except:

Meningitis

Multiple sclerosis

Fluid leakage

CNS malignancy

Correct! Wrong!

The integrity of the blood-brain barrier is measured using the:

CSF/serum albumin index

CSF/serum globulin ratio

CSF albumin index

CSF IgG index

Correct! Wrong!

Given the following results, calculate the IgG index: CSF IgG, 50 mg/dL; serum IgG, 2 gm/dL; CSF albumin, 70 mg/dL; serum albumin, 5 gm/dL.

0.6

6.0

1.8

2.8

Correct! Wrong!

The CSF IgG index calculated in Study Question 27 is indicative of:

Synthesis of IgG in the CNS

Damage to the blood-brain barrier

Cerebral hemorrhage

Lymphoma infiltration

Correct! Wrong!

The finding of oligoclonal bands in the CSF and not in the serum is seen with:

Multiple myeloma

CNS malignancy

Multiple sclerosis

Viral infections

Correct! Wrong!

A CSF glucose of 15 mg/dL, WBC count of 5000, 90% neutrophils, and protein of 80 mg/dL is suggestive of:

Fungal meningitis

Viral meningitis

Tubercular meningitis

Bacterial meningitis

Correct! Wrong!

A patient with a blood glucose of 120 mg/dL would have a normal CSF glucose of:

20 mg/dL

60 mg/dL

80 mg/dL

120 mg/dL

Correct! Wrong!

CSF lactate will be more consistantly decreased in:

Bacterial meningitis

Viral meningitis

Fungal meningitis

Tubercular meningitis

Correct! Wrong!

Measurement of which of the following can be replaced by CSF glutamine analysis in children with Reye syndrome?

Ammonia

Lactate

Glucose

ketoglutarate

Correct! Wrong!

Prior to performing a Gram stain on CSF, the specimen must be:

Filtered

Warmed to 37C

Centrifuged

Mixed

Correct! Wrong!

All of the following statements are true about cryptoccocal meningitis except:

An India Ink preparation is positive

A starburst pattern is seen on Gram stain

The WBC count is over 2000

A confirmatory immunology test is available

Correct! Wrong!

The test of choice to detect neurosyphilis is the:

RPR

VDRL

FTA

FTA-ABS

Correct! Wrong!

The quizzes about Cerebrospinal Fluid

Clinical laboratory improvement amendments

You are pretty good!

You are very good!

1. The functions of the CSF include all of the following except:
A. Removal of metabolic wastes
B. Producing an ultrafiltrate of plasma
C. Supplying nutrients to the CNS
D. Protection of the brain and spinal cord

2. The CSF flows through the:
A. Choroid plexus
B. Pia mater
C. Arachnoid space
D. Dura mater

3. Substances present in the CSF are contolled by the:
A. Arachnoid granulations
B. Blood-brain barrier
C. Presence of one-way valves
D. Blood-CSF barrier

4. The CSF tube labeled 3 is sent to:
A. The hematology department
B. The chemistry department
C. The microbiology department
D. The serology department

5. The CSF tube that should be refrigerated is:
A. Tube 1
B. Tube 2
C. Tube 3
D. Tube 4

6. Place the appropriate letter in front of the statement that best describes CSF specimens in these two conditions:
A. Traumatic tap
B. Intracranial hemorrhage
_____Even distribution of blood in all tubes
_____Xanthochromic supernatant
_____Concentration of blood in tube 1 is greater than in tube 3
_____Specimen contains clots

7. The presence of xanthochromia can be caused by all of the following except:
A. Immature liver function
B. RBC degradation
C. A recent hemorrhage
D. Elevated CSF protein

8. A web-like pellicle in a refrigerated CSF specimen is indicative of:
A. Tubercular meningitis
B. Multiple sclerosis
C. Primary CNS malignancy
D. Viral meningitis

9. Given the following information, calculate the CSF WBC count: cells counted, 80; dilution, 1:10; large
Neubauer squares counted, 10.
A. 8
B. 80
C. 800
D. 8000

10. A CSF WBC count is diluted with:
A. Distilled water
B. Normal saline
C. Acetic acid
D. Methylene blue

11. A total CSF cell count on a clear fluid should be:
A. Reported as normal
B. Not reported
C. Diluted with normal saline
D. Counted undiluted

12. The purpose of adding albumin to CSF before cytocentrifugation is to:
A. Increase the cell yield
B. Decrease the cellular distortion
C. Improve the cellular staining
D. Both A and B

13. The primary concern when pleocytosis of neutrophils and lymphocytes is found in the CSF is:
A. Meningitis
B. CNS malignancy
C. Multiple sclerosis
D. Hemorrhage

14. Neutrophils with pyknotic nuclei may be mistaken for:
A. Lymphocytes
B. Nucleated RBCs
C. Malignant cells
D. Spindle-shaped cells

15. The presence of which of the following cells is increased when a CNS shunt malfunctions?
A. Neutrophils
B. Macrophages
C. Eosinophils
D. Lymphocytes

16. Macrophages appear in the CSF following:
A. Hemorrhage
B. Repeated spinal taps
C. Diagnostic procedures
D. All of the above

17. Nucleated RBCs are seen in the CSF as a result of:
A. Elevated blood RBCs
B. Treatment of anemia
C. Severe hemorrhage
D. Bone marrow contamination

18. Following a CNS diagnostic procedure, which of the following might be seen in the CSF?
A. Choroidal cells
B. Ependymal cells
C. Spindle-shaped cells
D. All of the above

19. Hemosiderin granules and hematoidin crystals are seen in:
A. Lymphocytes
B. Macrophages
C. Ependymal cells
D. Neutrophils

20. Myeloblasts are seen in the CSF:
A. In bacterial infections
B. In conjunction with CNS malignancy
C. Following cerebral hemorrhage
D. As a complication of acute leukemia

21. Cells resembling large and small lymphocytes with cleaved nuclei represent:
A. Lymphoma cells
B. Choroid cells
C. Melanoma cells
D. Medulloblastoma cells

22. The normal value of CSF protein is:
A. 6–8 g/dL
B. 15–45 g/dL
C. 6–8 mg/dL
D. 15–45 mg/dL

23. CSF can be differentiated from plasma by the presence of:
A. Albumin
B. Globulin
C. Prealbumin
D. Tau transferrin

24. In plasma, the second most prevalent protein is IgG; in CSF, the second most prevalent protein is:
A. Transferrin
B. Prealbumin
C. IgA
D. Ceruloplasmin

25. Elevated CSF protein values can be caused by all of the following except:
A. Meningitis
B. Multiple sclerosis
C. Fluid leakage
D. CNS malignancy

26. The integrity of the blood-brain barrier is measured using the:
A. CSF/serum albumin index
B. CSF/serum globulin ratio
C. CSF albumin index
D. CSF IgG index

27. Given the following results, calculate the IgG index: CSF IgG, 50 mg/dL; serum IgG, 2 gm/dL; CSF albumin, 70 mg/dL; serum albumin, 5 gm/dL.
A. 0.6
B. 6.0
C. 1.8
D. 2.8

28. The CSF IgG index calculated in Study Question 27 is indicative of:
A. Synthesis of IgG in the CNS
B. Damage to the blood-brain barrier
C. Cerebral hemorrhage
D. Lymphoma infiltration

29. The finding of oligoclonal bands in the CSF and not in the serum is seen with:
A. Multiple myeloma
B. CNS malignancy
C. Multiple sclerosis
D. Viral infections

30. A CSF glucose of 15 mg/dL, WBC count of 5000, 90% neutrophils, and protein of 80 mg/dL is suggestive of:
A. Fungal meningitis
B. Viral meningitis
C. Tubercular meningitis
D. Bacterial meningitis

31. A patient with a blood glucose of 120 mg/dL would have a normal CSF glucose of:
A. 20 mg/dL
B. 60 mg/dL
C. 80 mg/dL
D. 120 mg/dL

32. CSF lactate will be more consistantly decreased in:
A. Bacterial meningitis
B. Viral meningitis
C. Fungal meningitis
D. Tubercular meningitis

33. Measurement of which of the following can be replaced by CSF glutamine analysis in children with Reye syndrome?
A. Ammonia
B. Lactate
C. Glucose
D. -ketoglutarate

34. Prior to performing a Gram stain on CSF, the specimen must be:
A. Filtered
B. Warmed to 37C
C. Centrifuged
D. Mixed

35. All of the following statements are true about cryptoccocal meningitis except:
A. An India Ink preparation is positive
B. A starburst pattern is seen on Gram stain
C. The WBC count is over 2000
D. A confirmatory immunology test is available

36. The test of choice to detect neurosyphilis is the:
A. RPR
B. VDRL
C. FTA
D. FTA-ABS

The quizzes about Cerebrospinal Fluid

Select the one best response to each question!

The functions of the CSF include all of the following except:

The CSF flows through the:

Substances present in the CSF are contolled by the:

The CSF tube labeled 3 is sent to:

The CSF tube that should be refrigerated is:

The presence of xanthochromia can be caused by all of the following except:

A web-like pellicle in a refrigerated CSF specimen is indicative of:

Given the following information, calculate the CSF WBC count: cells counted, 80; dilution, 1:10; large Neubauer squares counted, 10.

A CSF WBC count is diluted with:

A total CSF cell count on a clear fluid should be:

The purpose of adding albumin to CSF before cytocentrifugation is to:

The primary concern when pleocytosis of neutrophils and lymphocytes is found in the CSF is:

Neutrophils with pyknotic nuclei may be mistaken for:

The presence of which of the following cells is increased when a CNS shunt malfunctions?

Macrophages appear in the CSF following:

Nucleated RBCs are seen in the CSF as a result of:

Following a CNS diagnostic procedure, which of the following might be seen in the CSF?

Hemosiderin granules and hematoidin crystals are seen in:

Myeloblasts are seen in the CSF:

Cells resembling large and small lymphocytes with cleaved nuclei represent:

The normal value of CSF protein is:

CSF can be differentiated from plasma by the presence of:

In plasma, the second most prevalent protein is IgG; in CSF, the second most prevalent protein is:

Elevated CSF protein values can be caused by all of the following except:

The integrity of the blood-brain barrier is measured using the:

Given the following results, calculate the IgG index: CSF IgG, 50 mg/dL; serum IgG, 2 gm/dL; CSF albumin, 70 mg/dL; serum albumin, 5 gm/dL.

The CSF IgG index calculated in Study Question 27 is indicative of:

The finding of oligoclonal bands in the CSF and not in the serum is seen with:

A CSF glucose of 15 mg/dL, WBC count of 5000, 90% neutrophils, and protein of 80 mg/dL is suggestive of:

A patient with a blood glucose of 120 mg/dL would have a normal CSF glucose of:

CSF lactate will be more consistantly decreased in:

Measurement of which of the following can be replaced by CSF glutamine analysis in children with Reye syndrome?

Prior to performing a Gram stain on CSF, the specimen must be:

All of the following statements are true about cryptoccocal meningitis except:

The test of choice to detect neurosyphilis is the:

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