Home Laboratory QuizzesHaematology Quizzes [MCQs] Differential Leukocyte Count and Other Procedures – Part 2 (25 test)

[MCQs] Differential Leukocyte Count and Other Procedures – Part 2 (25 test)

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Part 1 (25 test) | Part 2 (25 test – end)  

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1. The normal range for the mean corpuscular volume of an erythrocyte is approximately:

  1. 62-82 fl.
  2. 70-80 fl.
  3. 80-97 fl.
  4. 90-100 fl

2. The osmotic fragility of erythrocytes is increased in:

  1. Thalassemia major.
  2. Sickle cell anemia.
  3. Iron deficiency (hypochromic) anemia.
  4. Congenital spherocytic (hemolytic) anemia.

3. When the osmotic fragility test is performed visually, the salt concentrations are recorded for the two tubes that show:

  1. 0% and 50% hemolysis.
  2. 0% and 100% hemolysis.
  3. Least and greatest hemolysis.
  4. Initial hemolysis and first complete hemolysis.

4. What is the normal percentage of hemolysis in 0.55% saline?

  1. 0%.
  2. 40%.
  3. 65%.
  4. 100%

5. The Ham test is positive in:

  1. Polycythemia.
  2. Paroxysmal nocturnal hemoglobinuria.
  3. Chronic lymphocytic leukemia.
  4. All hemoglobinopathies.

6. Erythrocytes in paroxysmal nocturnal hemoglobinuria lyse easily in serum which is slightly:

  1. Basic.
  2. Acidic.
  3. Hypotonic.
  4. Hypertonic.

7. A false-positive Ham test may occur in:

  1. Sickle cell anemia.
  2. Congenital spherocytic anemia.
  3. Severe iron deficiency anemia.
  4. Paroxysmal nocturnal hemoglobinuria.

8. When demonstrating “L.D.” cells, which of the following has degenerative nuclear material that attracts phagocytic cells, particular segmented neutrophis?

  1. Jaundice.
  2. Leukemia.
  3. Lupus erythematossus.
  4. Pernicious amenia.

9. Which method is used to determine L.E. cell and antinuclear antibodies with a 75-80% accuracy rate?

  1. Rotary bead.
  2. Fluorescent antibody.
  3. a and b.
  4. None of the above.

10. Lupus erythematosus is:

  1. A chronic, sometimes fatal, disease of unknown etiology.
  2. A regular skin eruption across the nose and mouth (butterfly rash), with arthritis that can be accompanied by various visceral manifestations.
  3. A rash, which is sometimes not present. Diagnosis depends on demonstration of the L.E. cell.
  4. Sometimes not diagnosed early because the early symptoms do not appear after intense exposure to sunlight.

11. Which statement is correct for the erythrocyte osmotic fragility test?

  1. In hypertonic salt solutions, erythrocytes take up water, swell to a spheroid shape and burst.
  2. In congenital spherocytic anemia, the WBCs with defective structure, will more rapidly rupture at salt concentrations closer to isotonicity (0.85 percent).
  3. The RBCs cells thus show an increased osmotic fragility. In contrast, the flat or thin but otherwise normal red cells of hypochromic anemia show a decreased osmotic fragility and do not hemolyze until lower salt concentrations are reached.
  4. When hemolysis begins within the normal range of the prepared solutions or when intermediate dilutions are desired, the additional dilutions are readily prepared using the 1 percent sodium chloride stock solution.

12. Which statement is correct for the erythrocyte osmotic fragility test?

  1. When the results of the fragility test are normal, one procedure is immediately followed to enhance any latent abnormality in fragility.
  2. Incubate samples of defibrinated blood (control and patient’s) at 37°C for 24 hours under sterile conditions and controlled pH (7.35-7.50).
  3. The test does not need to be performed.
  4. Increases in pH decrease osmotic fragility. The reagents are buffered to maintain a constant pH of 7.35-7.50.

13. Which statement is correct for the erythrocyte osmotic fragility test?

  1. This test may also be run visually, with some sacrifice of accuracy, by allowing the blood-saline dilutions to stand at 20°C for 45 minutes.
  2. The tubes are then vigorously centrifuged (1,000 rpm for 3 minutes) and observed for signs of initial and complete hemolysis.
  3. A rich dark pink coloration of the supernatant fluid indicates initial hemolysis and a cloudy red solution indicates complete hemolysis.
  4. Salt free concentrations in these two tubes are noted and recorded.
  5. The control does not have to be reported along with results of patient’s tubes.

14. When there is no “butterfly rash,” diagnosis of lupus erythematosus often depends upon demonstration of:

  1. Collagen.
  2. L.E. cells.
  3. Leukocytosis.
  4. Polycythemia.

15. In addition to L.E. cells, two characteristic phenomena in lupus erythematosus are:

  1. Free nuclear masses and rosettes.
  2. Rouleaux and Cabot rings.
  3. Basket cells and toxic granulation.
  4. Distorted lymphocytes and smudge cells.

16. Which of the following is easily mistaken for an L.E. cell?

  1. Tart cell.
  2. Monocyte.
  3. Plasmocyte.
  4. Segmented neutrophil.

17. Which of the following is peroxidase negative?

  1. Lymphocytes.
  2. Promyelocytes.
  3. Neutrophilic myelocytes.
  4. Neutrophilic metamyelocytes.
  5. Neutrophilic band cells.
  6. Neutrophilic segmented cells.

18. Which of the following is peroxidase positive?

  1. Lymphocytes.
  2. Plasmocytes.
  3. Segmented neutrophils.

19. With the alkaline phosphatase stain, a segmented neutrophil exhibiting no darkly stained granules is rated:

  1. 0.
  2. 1+ .
  3. 2+.
  4. 3+.
  5. 4+.

20. Generally speaking, when leukocyte alkaline phosphatase is used, a patient with what score is considered to be a healthy adult?

  1. 10-50.
  2. 10-80.
  3. 13-100
  4. 13-130


21. Heinz bodies are often present in the erythrocytes of hemolytic anemia caused by:

  1. Toxic agents.
  2. Spherocytosis.
  3. Thalassemia major.
  4. Paroxysmal nocturnal hemoglobinuria.

22. What color are Heinz-bodies when stained with methyl violet?

  1. Colorless.
  2. Blue-green.
  3. Purple.
  4. Black.

23. Heienz-bodies prepared with Wright-stain are what color?

  1. Green.
  2. Purple.
  3. Colorless
  4. Orange.

24. Siderocytes are:

  1. Iron granules.
  2. Denatured hemoglobin.
  3. Nucleated erythrocytes.
  4. Erythrocytes containing iron granules.

25. Siderocytes may be observed:

  1. All of the below.
  2. In several anemias.
  3. After splenectomy.
  4. In lead poisoning.

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