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HORMONE METABOLISM- Part 3
See all quizzes of HORMONE METABOLISM- Part 3 here:
1 Excess secretion of thyroid hormones
causes
(A) Hyperthyroidism (B) Myxoedema
(C) Cretinism (D) Cushing syndrome
2. Insufficient free T3 and T4 results in
(A) Grave’s disease (B) Mysoedema
(C) Cushing syndrome (D) Gigantism
3. In primary hypothyroidism the useful
estimation is of
(A) T3 (B) T4
(C) TBG (D) Autoantibodies
4. When iodine supplies are sufficient the T3
and T4 ratio in thyroglobulin is
(A) 1 : 2 (B) 1 : 4
(C) 1 : 7 (D) 1 : 10
5. A substance which competes with iodide
uptake mechanism by thyroid gland is
(A) Thiocynate (B) Iodoacetate
(C) Fluoride (D) Fluoroacetate
6. Thyroperoxidase enzyme contains
(A) Heme (B) Copper
(C) Zinc (D) Magnesium
7. Thyroproxidase requires hydrogen
peroxide as oxidizing agent. The H2O2 is
produced by
(A) FADH2 dependent enzyme
(B) NADH dependent enzyme
(C) NADP dependent enzyme
(D) NADPH dependent enzyme
8. Thyroid stimulating hormone is a dimer.
The α-subunits of TSH, LH, FSH are
identical. Thus the biological specificity
must therefore be β subunit in which the
number of amino acids is
(A) 78 (B) 112
(C) 130 (D) 199
9. TSH stimulates the synthesis delete
(A) Thyroxine (B) Adrenocorticoids
(C) Epinephrine (D) Insulin
10. Thyroid hormones are synthesized by the
iodination of the amino acid:
(A) Glycine (B) Phenylalanine
(C) Alanine (D) Tyrosine
11. The tyrosine residues per molecule of
thyroglobulin is
(A) 85 (B) 95
(C) 115 (D) 135
12. The percentage of inactive precursors
(monoidotyrosine and diiodotyrosine) in
thyroglobulin is
(A) 30 (B) 40
(C) 50 (D) 70
13. The number of amino acids in parathormone
is
(A) 65 (B) 84
(C) 115 (D) 122
14. The sequence of amino acid in which the
biological value of parathormone is
(A) 1–15 (B) 1–34
(C) 30–50 (D) 50–84
15. PTH
(A) Reduces the renal clearance or excretion of
calcium
(B) Increases renal phosphate clearance
(C) Increases the renal clearance of calcium
(D) Decreases the renal phosphate clearance
16. The number of amino acids in the peptide
hormone calcitonin is
(A) 16 (B) 24
(C) 32 (D) 40
17. Calcitonin causes
(A) Calcinuria and phosphaturia
(B) Decrease in urinary calcium
(C) Decrease in urinary phosphorous
(D) Increase in blood calcium level
18. The characteristic of hyperparathyroidism
is
(A) Low serum calcium
(B) High serum phosphorous
(C) Low serum calcium and high serum phosphorous
(D) High serum calcium and low serum
phosphate
19. Parathyroid hormone
(A) Is released when serum Ca++ is too high
(B) Inactivates vitamin D
(C) Is secreted when Ca++ is too low
(D) Depends on vitamin K for adequate activity
20. δ-Cells of islet of langerhans of pancreas
produce
(A) Pancreatic polypeptide
(B) Pancreatic lipase
(C) Somatostatin
(D) Steapsin
21. β-cells of islet of langerhans of the
pancreas secrete
(A) Insulin
(B) Glucagon
(C) Somatostatin
(D) Pancreatic polypeptide
22. Target tissue of insulin is
(A) Red blood cells
(B) Renal tubular cells
(C) GI tract epithelial cells
(D) Liver
23. Insulin is a dimmer. The number of amino
acids in the A and B chain respectively is
(A) 19 and 28 (B) 21 and 30
(C) 25 and 35 (D) 29 and 38
24. In A chain of the insulin molecule the Nterminal
amino acid is
(A) Glycine (B) Valine
(C) Serine (D) Phenylalanine
25. In the A chain of insulin molecule the Cterminal
amino acid is
(A) Asparagine (B) Threonine
(C) Valine (D) Tyrosine
26. In the B chain of insulin molecule, the Nterminal
amino acid is
(A) Proline (B) Threonine
(C) Phenylalanine (D) Lysine
27. In the B chain of insulin molecule, the
C-terminal amino acid:
(A) Threonine (B) Tyrosine
(C) Glutamate (D) Valine
28. In the insulin molecule, the number of
interchain disulphide brides is
(A) 1 (B) 2
(C) 3 (D) 4
29. In the insulin molecule, the number of
intrachain disulphide bridges is
(A) 1 (B) 2
(C) 3 (D) 4
30. Insulin exists in polymeric forms, for
polymerization it requires
(A) Calcium (B) Magnesium
(C) Manganese (D) Zinc
