The Granulocytic and Monocytic Series

What is the normal range of the segmented neutrophil absolute value?

1.4 to 6 × 10^9/L

2.5 to 6.5 × 10^9/L

3.5 to 8 × 10^9/L

5.5 to 10 × 10^9/L

Correct! Wrong!

An increase in metamyelocytes, myelocytes, and promyelocytes can be referred to as

leukocytopenia

a shift to the right

a shift to the left

Pelger-Huet anomaly

Correct! Wrong!

The half-life of circulating granulocytes in normal blood is estimated to be

2.5 to 5 hours

7 to 10 hours

24 hours

2 days

Correct! Wrong!

On the basis of the following data, calculate the absolute value of the segmented neutrophils. Total leukocyte count = 12 × 10^9/L; percentage of segmented neutrophils on the differential count = 80%. The absolute segmented neutrophil value is

2.5 × 10^9/L

4.5 × 10^9/L

6.5 × 10^9/L

9.6 × 10^9/L

Correct! Wrong!

The types of granulocytic leukocytes found in the proliferative compartment of the bone marrow are

myeloblasts, myelocytes, and metamyelocytes

myeloblasts, promyelocytes, and myelocytes

myeloblasts, promyelocytes, myelocytes, and metamyelocytes

myeloblasts, promyelocytes, myelocytes, metamyelocytes, and band neutrophils

Correct! Wrong!

The earliest granulocytic maturational stage in which secondary or specifi c granules appear is

myeloblast

monoblast

promyelocyte

myelocyte

Correct! Wrong!

The absolute value of segmented neutrophils can be an unreliable indicator of overwhelming infection because

it drops in many patients because the circulating granulocytes are mobilized into the tissue site of infection

the bone marrow reserve becomes exhausted

the infection suppresses granulocytic production

All of the above

Correct! Wrong!

The granules of segmented neutrophils contain

lysosomal hydrolases

lysozymes

myeloperoxidase

all of the above

Correct! Wrong!

Identify the cell with these characteristics: prominent primary granules that are rich in myeloperoxidase and chloroacetate esterase and has a diameter of 14 to 20 mm.

myeloblast

promyelocyte

myelocyte

promonocyte

Correct! Wrong!

The reference range of PMN neutrophil count in adults is

20 – 40%

40 – 60%

60 – 80%

80 – 100%

Correct! Wrong!

The granulocyte cells that are believed to descend from a common multipotential stem cell in the bone marrow are

neutrophils and eosinophils

basophils and lymphocytes

lymphocytes and monocytes

Both A and B

Correct! Wrong!

The types of granulocytic leukocytes found in the maturation-storage compartment of the bone marrow are

metamyelocytes, band form neutrophils, segmented neutrophils, mature eosinophils, and mature basophils

only band form neutrophils, segmented neutrophils, mature eosinophils, and mature basophils

metamyelocytes, band form neutrophils, segmented neutrophils, mature eosinophils, and mature basophils

segmented neutrophils, immature and mature monocytes, and mature lymphocytes

Correct! Wrong!

The major function of neutrophilic granulocytes is

antibody production

destruction of parasites

phagocytosis

suppression of inflammation

Correct! Wrong!

The principal leukocyte type involved in phagocytosis is the

monocyte

neutrophil

eosinophil

basophil

Correct! Wrong!

The total leukocyte count can be increased in certain states. Select the conditions when this is not true.

Strenuous exercise

Overwhelming bacterial infection

Sepsis

Use of immunosuppressive agents

Correct! Wrong!

A leukocyte with the morphological characteristics of being the largest normal mature leukocyte in the peripheral blood and having a convoluted or twisted nucleus is the

myelocyte

metamyelocyte

promonocyte

monocyte

Correct! Wrong!

Acute infl ammation is based on

total leukocyte count >10.5 × 10^9/L

neutrophilic band count <2%

symptoms of long duration

an increase in lymphocytes

Correct! Wrong!

The stages of neutrophilic granulocyte development are

promyelocyte, myeloblast, myelocyte, metamyelocyte, and band and segmented neutrophils

myeloblast, promyelocyte, myelocyte, metamyelocyte, and band and segmented neutrophils

myelocyte, myeloblast, promyelocyte, metamyelocyte, and band and segmented neutrophils

myeloblast, promyelocyte, metamyelocyte, myelocyte, and band and segmented neutrophils

Correct! Wrong!

Release of neutrophils from the bone marrow is believed to be influenced by

CSF

interleukins

interferon

all of the above

Correct! Wrong!

The mature granulocytes seen in the peripheral blood of healthy persons include

band form and segmented neutrophils

eosinophils and basophils

lymphocytes and monocytes

Both A and B

Correct! Wrong!

The mononuclear phagocyte system consists of reticular cells. These cells can be found in the

connective tissue

spleen

lymph nodes

all of the above

Correct! Wrong!

Marginating granulocytes in the peripheral blood can be found

in the circulating pool

in the tissues

adhering to the vascular endothelium

all of the above

Correct! Wrong!

The correct sequence(s) of events in successful phagocytosis is (are)

chemotaxis, opsonization, phagosome formation, and the action of antibacterial substances

opsonization, chemotaxis, phagosome formation, and the action of antibacterial substances

engulfment, opsonization, digestion, and destruction of bacteria or particulate matter

Both A and C

Correct! Wrong!

Monocytes are capable of

phagocytosis

synthesis of biologically important compounds

assuming a killer role

All of the above

Correct! Wrong!

The immediate precursor of the macrophage is the

myeloblast

monoblast

promonocyte

monocyte

Correct! Wrong!

The major function of eosinophils is

suppression of inflammatory reactions

destruction of protozoa

participation in anaphylaxis

phagocytosis

Correct! Wrong!

The tissue basophil can be referred to as a/an

mast cell

macrophage

mononuclear cell

antibody-producing cell

Correct! Wrong!

Which of the following are contents of basophilic granules?

Heparin

Histamine

Myeloperoxidase

Both A and B

Correct! Wrong!

The hematology tests that are useful in the early diagnosis of acute infl ammation are the

total leukocyte count and total erythrocyte count

total leukocyte count and white blood cell differential count

ESR and absolute neutrophil cell count

Both B and C

Correct! Wrong!

The CLSI-recommended method for the ESR is the

Wintrobe method

Westergren method

Duke

Ivy

Correct! Wrong!

The Granulocytic and Monocytic Series

Bad

pretty good

Good

Very good

The Granulocytic and Monocytic Series

What is the normal range of the segmented neutrophil absolute value?

An increase in metamyelocytes, myelocytes, and promyelocytes can be referred to as

The half-life of circulating granulocytes in normal blood is estimated to be

On the basis of the following data, calculate the absolute value of the segmented neutrophils. Total leukocyte count = 12 × 10^9/L; percentage of segmented neutrophils on the differential count = 80%. The absolute segmented neutrophil value is

The types of granulocytic leukocytes found in the proliferative compartment of the bone marrow are

The earliest granulocytic maturational stage in which secondary or specifi c granules appear is

The absolute value of segmented neutrophils can be an unreliable indicator of overwhelming infection because

The granules of segmented neutrophils contain

Identify the cell with these characteristics: prominent primary granules that are rich in myeloperoxidase and chloroacetate esterase and has a diameter of 14 to 20 mm.

The reference range of PMN neutrophil count in adults is

The granulocyte cells that are believed to descend from a common multipotential stem cell in the bone marrow are

The types of granulocytic leukocytes found in the maturation-storage compartment of the bone marrow are

The major function of neutrophilic granulocytes is

The principal leukocyte type involved in phagocytosis is the

The total leukocyte count can be increased in certain states. Select the conditions when this is not true.

A leukocyte with the morphological characteristics of being the largest normal mature leukocyte in the peripheral blood and having a convoluted or twisted nucleus is the

Acute infl ammation is based on

The stages of neutrophilic granulocyte development are

Release of neutrophils from the bone marrow is believed to be influenced by

The mature granulocytes seen in the peripheral blood of healthy persons include

The mononuclear phagocyte system consists of reticular cells. These cells can be found in the

Marginating granulocytes in the peripheral blood can be found

The correct sequence(s) of events in successful phagocytosis is (are)

Monocytes are capable of

The immediate precursor of the macrophage is the

The major function of eosinophils is

The tissue basophil can be referred to as a/an

Which of the following are contents of basophilic granules?

The hematology tests that are useful in the early diagnosis of acute infl ammation are the

The CLSI-recommended method for the ESR is the

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