The Quizzes about Immunology – Part 2

Radial immunodiffusion and immunoelectrophoresis is performed on a young patient to evaluate the function of his humoral immune system. Which of the following immunoglobulins has no known function, is found in the serum in low concentrations, and is present on the surface of B lymphocytes (may function as an antigen receptor)?

A young patient with severe recurrent pyogenic bacterial infections, but with normal T-cell and B-cell numbers, arrives at the hospital. Testing reveals that this patient’s CD4 T-helper cells have a defect in CD40 ligand. As a result, humoral immunity evaluation reveals a significant elevation in the levels of which immunoglobulin that is present as a monomer on B-cell surfaces, as a pentamer in serum, and is initially seen in the primary immune response?

A patient with a long history of consuming poorly cooked pork meat presents with generalized myalgia and a low-grade fever. Striated muscle biopsy reveals multiple cysts. Eosinophilia is also present with elevated levels of which of the following immunoglobulins most likely involved in parasitic infections?

A patient with cerebellar problems and spider angiomas is diagnosed with a combined T-cell and B-cell deficiency known as ataxiatelangiectasia. In addition to a defect in this patient’s DNA repair enzymes, which immunoglobulin is the primary antibody in saliva, tears, and intestinal and genital secretions, and is also deficient in this illness?

With four subclasses, which immunoglobulin is the predominant antibody in the secondary immune response and has the greatest concentration of the five immunoglobulin classes in the fetus?

A 15-year-old boy is bitten by an Ixodes tick while camping with his parents and presents 1 week later with fatigue, fever, headache, and a reddish rash over his trunk and extremities. Positive IgM antibody (1:200) to Borrelia burgdorferi is associated with which of the following?

A small child presents with a low-grade fever, coryza, sore throat, a bright red rash on his cheeks, and a less intense erythematous rash on his body. Elevated IgG and IgM antibody titers to parvovirus suggest a diagnosis of which of the following?

Blood from a woman at a local pregnancy clinic is analyzed for antibody titers to known pathogens. A negative varicella antibody titer in this young woman signifies which of the following?

A pediatric patient with progressively developing degenerative neurologic disease/disorder has an elevated CSF antibody titer to measles virus. You should suspect which of the following?

A 21-year-old patient in severe kidney failure receives a kidney from his 30-year-old brother. This type of transplantation is best described by which of the following?

During the infancy days of cardiac transplantation, nonhuman primate hearts were transplanted into humans to save lives. This type of transplantation is best described by which one of the following?

Humoral immunity evaluation mainly consists of measuring the amount of IgG, IgM, and IgA in the patient’s serum. These three immunoglobulins represent three distinct isotypes. An isotype is characterized by which of the following?

A 30-year-old male presents to the emergency room with difficulty in breathing and abdominal pain. Upon physical examination, you notice diffuse areas of nondependent, nonpitting swelling without pruritus, with predilection for the face, especially the perioral and periorbital areas. You also notice swelling in the mouth, pharynx, and larynx. Laboratory analysis of blood drawn from this patient indicates a complement problem. Which of the following is most likely?

A 45-year-old businesswoman arrives in your office with vague abdominal complaints. She has noticed melenic stool. Upon performing a sigmoidoscopy, you find a 4-cm mass in the upper colon. You should immediately order a blood test for which of the following tumor markers?

An 18-year-old male heroin addict, who practices the sharing of needles at a “shooting gallery,” is positive in the screening test for AIDS. This patient is most likely to be immunodeficient because of which one of the following?