[MCQs] Iron Deficiency and Other Hypoproliferative Anemias - Part 1

I. Start the exam by click the “Start” button

Iron Deficiency and Other Hypoproliferative Anemias- Part 1

Please wait while the activity loads.
If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled.

If loading fails, click here to try again

Start

Congratulations - you have completed Iron Deficiency and Other Hypoproliferative Anemias- Part 1. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

Your answers are highlighted below.

Question 1

Which of the following is false about hypoproliferative anemias ?

A	Normocytic RBC’s
B	Normochromic RBC’s
C	Reticulocyte index < 2.0 - 2.5
D	None of the above

Question 1 Explanation:

Anemias associated with normocytic and normochromic red cells and an inappropriately low reticulocyte response (reticulocyte index < 2.0 - 2.5) are hypoproliferative anemias.

Question 2

Which of the following is a hypoproliferative anemia ?

A	Anemia of acute and chronic inflammation
B	Anemia of hypometabolic states
C	Anemias from marrow damage
D	All of the above

Question 2 Explanation:

Hypoproliferative anemias include early iron deficiency, acute and chronic inflammation, renal disease, hypometabolic states (protein malnutrition & endocrine deficiencies), and anemias from marrow damage

Question 3

Most common anemia among hypoproliferative anemias is ?

A	Anemias associated with renal disease
B	Anemias associated with chronic inflammation
C	Anemias associated with cancer
D	Anemias associated with hypometabolic states

Question 3 Explanation:

anemia associated with chronic inflammation is the most common of the above mentioned hypoproliferative anemias. All these are characterized by an abnormal erythropoietin response to the anemia.

Question 4

Which of the following is called iron transport protein ?

A	Ferritin
B	Transferrin
C	Divalent metal transporter 1 (DMT1)
D	All of the above

Question 4 Explanation:

Iron absorbed from the diet or released from stores circulates in the plasma bound to transferrin, the iron transport protein.

Question 5

Turnover or half-clearance time of transferrin-bound iron is ?

A	5 - 10 minutes
B	10 - 30 minutes
C	30 - 60 minutes
D	60 - 90 minutes

Question 5 Explanation:

Turnover or half-clearance time of transferrin-bound iron is 60 - 90 minutes

Question 6

Which of the following has the highest affinity for transferrin receptors ?

A	Monoferric transferrin
B	Diferric transferrin
C	Apotransferrin
D	All of the above

Question 6 Explanation:

Iron-transferrin complex in plasma interacts with specific transferrin receptors on marrow erythroid cell surface. Diferric transferrin has the highest affinity for transferrin receptors. Apotransferrin does not carry iron and has very little affinity for transferrin receptors

Question 7

Daily requirement of dietary iron in adult man is ?

A	1 mg
B	2 mg
C	3 mg
D	4 mg

Question 7 Explanation:

Normally, an adult male needs ~1 mg of elemental iron daily, while females in childbearing years need 1.4 mg/day

Question 8

During the last two trimesters of pregnancy, daily iron requirements increase to ?

A	2 to 3 mg
B	3 to 4 mg
C	3 to 4 mg
D	5 to 6 mg

Question 8 Explanation:

During the last two trimesters of pregnancy, daily iron requirements increase to 5 - 6 mg/day

Question 9

Transferrin-receptor complex is internalized via ?

A	Etharin-coated pits
B	Megalin-coated pits
C	Clathrin-coated pits
D	Azalin-coated pits

Question 9 Explanation:

Azalin-coated pits

Question 10

In erythroid cell, excess iron binds to which of the following to form ferritin ?

A	Apoferritin
B	Transferritin
C	Coferritin
D	Endoferritin

Question 10 Explanation:

In erythroid cell, excess iron binds to Apoferritin to form ferritin.

Question 11

What proportion of red cells turn over each day ?

A	0.2 to 0.4 %
B	0.4 to 0.6 %
C	0.6 to 0.8 %
D	0.8 to 1.0 %

Question 11 Explanation:

Normally, average RBC life span is 120 days. Thus, 0.8 - 1.0 % of red cells turn over each day

Question 12

Each milliliter of red cells contain how much elemental iron ?

A	1 mg
B	2 mg
C	3 mg
D	4 mg

Question 12 Explanation:

Each milliliter of red cells contains 1 mg of elemental iron.

Question 13

Iron absorption takes place largely in ?

A	Stomach
B	Proximal small intestine
C	Distal small intestine
D	Large intestine

Question 13 Explanation:

Iron absorption takes place largely in proximal small intestinethrough a carefully regulated process

Question 14

Reduction of ferric (Fe3+) to ferrous (Fe2+) iron at brush border membrane of duodenal enterocytes is done by ?

A	Duodenal hepcidin
B	Duodenal ferroportin
C	Duodenal hephaestin
D	Duodenal cytochrome B (Dcytb)

Question 14 Explanation:

Dietary inorganic iron traverses brush border membrane of duodenal enterocytes via DMT1 after reduction of ferric (Fe3+) to ferrous (Fe2+) iron by duodenal cytochrome B (Dcytb) - a ferrireductase.

Question 15

Iron transport across the enteric absorptive cell membrane is accomplished by ?

A	Duodenal cytochrome B (Dcytb)
B	Hephaestin
C	Ferroportin
D	Divalent metal transporter 1 (DMT-1)

Question 15 Explanation:

Iron transport across enteric absorptive cell membrane is achieved by Divalent metal transporter 1 (DMT-1). DMT-1 is a general cation transporter and is also known as natural resistance macrophage-associated protein type 2 (Nramp 2) or DCT-1

Question 16

Iron in gut cell is transported through its basolateral surface to plasma transferrin through ?

A	Duodenal cytochrome B (Dcytb)
B	Hephaestin
C	Ferroportin (FPN)
D	Divalent metal transporter 1 (DMT-1)

Question 16 Explanation:

In gut cell, iron may be stored as ferritin or released at basolateral surface to plasma transferrin through membrane-embedded iron exporter, ferroportin (FPN).

Question 17

Which of the following oxidizes iron to ferric form for transferrin binding at the basolateral surface of gut cell ?

A	Duodenal cytochrome B (Dcytb)
B	Hephaestin
C	Ferroportin
D	Divalent metal transporter 1 (DMT-1)

Question 17 Explanation:

Iron moves from enterocyte into circulation via a process requiring basolateral iron exporter ferroportin (FPN) & iron oxidase hephaestin (Heph) - which oxidizes iron to ferric form for transferrin binding.

Question 18

Hephaestin is similar to which of the following ?

A	Ferritin
B	Erythropoietin
C	C-reactive protein
D	Ceruloplasmin

Question 18 Explanation:

Hephaestin is similar to ceruloplasmin, the copper-carrying protein

Question 19

Hepcidin is derived from ?

A	Bone marrow
B	Liver
C	Duodenum
D	Spleen

Question 19 Explanation:

Hepcidin is a 25-amino-acid peptide made by the liver

Question 20

Which of the following is called “iron regulatory hormone” ?

A	Ferritin
B	Transferrin
C	Erythropoietin
D	Erythropoietin

Question 21

Hepcidin principally acts on which of the following ?

A	Duodenal cytochrome B (Dcytb)
B	Hephaestin
C	Ferroportin
D	Divalent metal transporter 1 (DMT-1)

Question 21 Explanation:

Divalent metal transporter 1 (DMT-1)

Question 22

Hepcidin responds to signals mediated by ?

A	HFE
B	TfR2 (transferrin receptor 2)
C	Hemojuvelin (HJV)
D	All of the above

Question 22 Explanation:

Hepcidin responds to changes in body iron requirements by signals mediated by HFE, TfR2 & hemojuvelin (HJV). Mutations in the genes encoding HFE, TfR2, hemojuvelin, and hepcidin lead to decreased hepcidin release and increased iron absorption, resulting in hemochromatosis

Question 23

Bone marrow iron stores are absent when serum ferritin level is ?

A	< 15 µg/L
B	< 25 µg/L
C	< 35 µg/L
D	< 45 µg/L

Question 23 Explanation:

Bone marrow iron stores are absent when the serum ferritin level is <15 µg/L

Question 24

Hemoglobin synthesis is impaired when transferrin saturation falls to ?

A	10 to 15 %
B	15 to 20 %
C	20 to 25 %
D	25 to 30 %

Question 24 Explanation:

Once the transferrin saturation falls to 15 - 20%, hemoglobin synthesis becomes impaired. This is a period of iron-deficient erythropoiesis. When transferrin saturation is 10 - 15%, hemoglobin & hematocrit begin to fall, reflecting iron-deficiency anemia.

Once you are finished, click the button below. Any items you have not completed will be marked incorrect. Get Results

There are 24 questions to complete.

←

List

→

Return

Shaded items are complete.

1	2	3	4	5
6	7	8	9	10
11	12	13	14	15
16	17	18	19	20
21	22	23	24	End

Return

See all quizzes of the Iron Deficiency and Other Hypoproliferative Anemias at here:

Iron Deficiency and Other Hypoproliferative Anemias – part 1 | Iron Deficiency and Other Hypoproliferative Anemias – part 2

II. Preview all questions below

1.Which of the following is false about hypoproliferative anemias ?
A. Normocytic RBC’s
B. Normochromic RBC’s
C. Reticulocyte index < 2.0 – 2.5
D. None of the above

2. Which of the following is a hypoproliferative anemia ?
A. Anemia of acute and chronic inflammation
B. Anemia of hypometabolic states
C. Anemias from marrow damage
D. All of the above

3. Most common anemia among hypoproliferative anemias is ?
A. Anemias associated with renal disease
B. Anemias associated with chronic inflammation
C. Anemias associated with cancer
D. Anemias associated with hypometabolic states

4. Which of the following is called iron transport protein ?
A. Ferritin
B. Transferrin
C. Divalent metal transporter 1 (DMT1)
D. All of the above

5. Turnover or half-clearance time of transferrin-bound iron is ?
A. 5 – 10 minutes
B. 10 – 30 minutes
C. 30 – 60 minutes
D. 60 – 90 minutes

6. Which of the following has the highest affinity for transferrin receptors ?
A. Monoferric transferrin
B. Diferric transferrin
C. Apotransferrin
D. All of the above

7. Daily requirement of dietary iron in adult man is ?
A. 1 mg
B. 2 mg
C. 3 mg
D. 4 mg

8. During the last two trimesters of pregnancy, daily iron requirements increase to ?
A. 2 to 3 mg
B. 3 to 4 mg
C. 4 to 5 mg
D. 5 to 6 mg

9. Transferrin-receptor complex is internalized via ?

A. Etharin-coated pits
B. Megalin-coated pits
C. Clathrin-coated pits
D. Azalin-coated pits

10. In erythroid cell, excess iron binds to which of the following to form ferritin ?
A. Apoferritin
B. Transferritin
C. Coferritin
D. Endoferritin

11. What proportion of red cells turn over each day ?
A. 0.2 to 0.4 %
B. 0.4 to 0.6 %
C. 0.6 to 0.8 %
D. 0.8 to 1.0 %

12. Each milliliter of red cells contain how much elemental iron ?
A. 1 mg
B. 2 mg
C. 3 mg
D. 4 mg

13. Iron absorption takes place largely in ?
A. Stomach
B. Proximal small intestine
C. Distal small intestine
D. Large intestine

14. Reduction of ferric (Fe3+) to ferrous (Fe2+) iron at brush border membrane of duodenal enterocytes is done by ?
A. Duodenal hepcidin
B. Duodenal ferroportin
C. Duodenal hephaestin
D. Duodenal cytochrome B (Dcytb)

15. Iron transport across the enteric absorptive cell membrane is accomplished by ?
A. Duodenal cytochrome B (Dcytb)
B. Hephaestin
C. Ferroportin
D. Divalent metal transporter 1 (DMT-1)

16. Iron in gut cell is transported through its basolateral surface to plasma transferrin through ?
A. Duodenal cytochrome B (Dcytb)
B. Hephaestin
C. Ferroportin (FPN)
D. Divalent metal transporter 1 (DMT-1)

17. Which of the following oxidizes iron to ferric form for transferrin binding at the basolateral surface of gut cell ?
A. Duodenal cytochrome B (Dcytb)
B. Hephaestin
C. Ferroportin
D. Divalent metal transporter 1 (DMT-1)

18. Hephaestin is similar to which of the following ?
A. Ferritin
B. Erythropoietin
C. C-reactive protein
D. Ceruloplasmin

19. Hepcidin is derived from ?
A. Bone marrow
B. Liver
C. Duodenum
D. Spleen

20. Which of the following is called “iron regulatory hormone” ?
A. Ferritin
B. Transferrin
C. Erythropoietin
D. Hepcidin

21. Hepcidin principally acts on which of the following ?
A. Duodenal cytochrome B (Dcytb)
B. Hephaestin
C. Ferroportin
D. Divalent metal transporter 1 (DMT-1)

22. Hepcidin responds to signals mediated by ?
A. HFE
B. TfR2 (transferrin receptor 2)
C. Hemojuvelin (HJV)
D. All of the above

23. Bone marrow iron stores are absent when serum ferritin level is ?
A. < 15 µg/L
B. < 25 µg/L
C. < 35 µg/L
D. < 45 µg/L

24. Hemoglobin synthesis is impaired when transferrin saturation falls to ?

A. 10 to 15 %

B. 15 to 20 %
C. 20 to 25 %
D. 25 to 30 %

[MCQs] Iron Deficiency and Other Hypoproliferative Anemias – Part 1

I. Start the exam by click the “Start” button

Iron Deficiency and Other Hypoproliferative Anemias- Part 1

II. Preview all questions below

Share this:

Related

[MCQs] Enlargement of Lymph Nodes & Spleen – Part 2

[MCQs] Iron Deficiency and Other Hypoproliferative Anemias – Part 2

You may also like

Leave a Comment Cancel Reply