[MCQs] Acute and Chronic Myeloid Leukemia - Part 2

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Acute and Chronic Myeloid Leukemia- Part 2

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Question 1

Normal range for plasma erythropoietin is ?

A	1 to 11 mU / mL
B	4 to 26 mU / mL
C	21 to 54 mU / mL
D	34 to 90 mU / mL

Question 1 Explanation:

Normal range for plasma erythropoietin is 4 to 26 mU/mL.

Question 2

Which of the following is false about polycythemia vera ?

A	Erythroid progenitor cells are resistant to apoptosis
B	Autonomous clonal form of erythrocytosis
C	Elevated plasma erythropoietin level excludes polycythemia vera as the cause for erythrocytosis
D	Abundant bone marrow iron

Question 2 Explanation:

Absent marrow iron in the presence of marrow hypercellularity is

Question 3

Thrombosis in polycythemia vera is due to ?

A	Erythrocytosis
B	Leucocytosis
C	Thrombocytosis
D	All of the above

Question 3 Explanation:

Thrombosis due to erythrocytosis is the most significant complication of PV

Question 4

Drug ‘Anagrelide’ is a ?

A	Phosphodiesterase inhibitor
B	Salicylate isomer
C	Anticoagulant
D	Cytotoxic agent

Question 4 Explanation:

Anagrelide, a phosphodiesterase inhibitor, can reduce the platelet count and is preferable to hydroxyurea because it lacks marrow toxicity. Anagrelide is protective against venous thrombosis.

Question 5

Chronic primary myelofibrosis is characterised by all except ?

A	Jaundice
B	Marrow fibrosis
C	Extramedullary hematopoiesis
D	Splenomegaly

Question 5 Explanation:

dehehrtChronic PMF is a clonal disorder of a multipotent hematopoietic progenitor cell of unknown etiology characterized by marrow fibrosis, extramedullary hematopoiesis, and splenomegaly

Question 6

JAK2 V617F is present in what percentage of PMF patients ?

A	10 %
B	25 %
C	50 %
D	75 %

Question 6 Explanation:

JAK2 V617F is present in approximately 50% of PMF patients and mutations in the thrombopoietin receptor Mpl occur in about 5%.

Question 7

Fibrosis and osteosclerosis in PMF is due to ?

A	Overproduction of transforming growth factor
B	Overproduction of tissue inhibitors of metalloproteinases
C	Overproduction of osteoprotegerin
D	All of the above

Question 7 Explanation:

Fibrosis in PMF is due to overproduction of transforming growth factor and tissue inhibitors of metalloproteinases, while osteosclerosis is due to overproduction of osteoprotegerin, an osteoclast inhibitor. Marrow angiogenesis is due to increased production of vascular endothelial growth factor. Fibroblasts in PMF are polyclonal and not part of the neoplastic clone

Question 8

Exuberant extramedullary hematopoiesis can cause which of the following ?

A	Pulmonary hypertension
B	Intracranial hypertension
C	Spinal cord compression
D	All of the above

Question 8 Explanation:

Exuberant extramedullary hematopoiesis can cause ascites, pulmonary hypertension, intestinal or ureteral obstruction, intracranial hypertension, pericardial tamponade, spinal cord compression, skin nodules, rapid splenic enlargement & splenic infarctions, & hyperuricemia & secondary gout.

Question 9

Presence of which of the following establishes the occurrence of extramedullary hematopoiesis ?

A	Teardrop-shaped red cells
B	Nucleated red cells
C	Myelocytes and promyelocytes
D	All of the above

Question 9 Explanation:

The presence of teardrop-shaped red cells, nucleated red cells, myelocytes, and promyelocytes establishes the presence of extramedullary hematopoiesis.

Question 10

In PMF, which of the following is seen ?

A	Antinuclear antibodies
B	Rheumatoid factor
C	Positive Coombs’ test
D	All of the above

Question 10 Explanation:

An intriguing feature of PMF is the occurrence of autoimmune abnormalities such as immune complexes, antinuclear antibodies, rheumatoid factor, or a positive Coombs’ test

Question 11

Which of the following is false about essential thrombocytosis ?

A	Clonal disorder of unknown etiology
B	Female predominance
C	Patients have hemorrhagic & thrombotic tendencies
D	None of the above

Question 11 Explanation:

Very high platelet counts are associated primarily with hemorrhage due to acquired von Willebrand disease.

Question 12

Disorders that can masquerade as essential thrombocytosis include ?

A	CML
B	Polycythemia vera
C	Myelodysplasia
D	All of the above

Question 12 Explanation:

CML, polycythemia vera, or myelodysplasia can masquerade as essential thrombocytosis

Question 13

‘Mpl’ is the receptor for ?

A	Erythropoietin
B	Granulocyte-macrophage colony-stimulating factor
C	Thrombopoietin
D	All of the above

Question 13 Explanation:

Megakaryocytopoiesis and platelet production depend upon thrombopoietin and its receptor, Mpl in addition to interleukin 3 (IL-3) and stem cell factor. Their subsequent development is also enhanced by the chemokine stromal cell-derived factor 1 (SDF-1).

Question 14

Megakaryocyte receptor of thrombopoietin (TPO) is ?

A	a-mpl
B	b-mpl
C	c-mpl
D	d-mpl

Question 14 Explanation:

Megakaryocyte receptor of TPO is a protooncogene c-mpl. TPO (c-mpl ligand) is secreted continuously at a low level and binds tightly to circulating platelets. A reduction in platelet count increases the level of free TPO & thereby stimulates megakaryocyte & platelet production.

Question 15

Thrombopoietin is produced in ?

A	Liver
B	Pancreas
C	Lungs
D	Thymus

Question 15 Explanation:

Like erythropoietin, thrombopoietin is produced in both the liver and the kidneys, and an inverse correlation exists between the platelet count and plasma thrombopoietic activity

Question 16

Gene for thrombopoietin is located on which chromosome ?

A	1
B	2
C	3
D	4

Question 16 Explanation:

Genes for thrombopoietin and its receptor Mpl are located on chromosomes 3 and 1 respectively

Question 17

Bleeding associated with thrombocytosis responds to ?

A	Salicylates
B	IFN-
C	Anagrelide
D	. -aminocaproic acid

Question 17 Explanation:

Bleeding associated with thrombocytosis usually responds to -aminocaproic acid

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See all quizzes of the Acute and Chronic Myeloid Leukemia- Part 2 at here:

Acute and Chronic Myeloid Leukemia Part 1 | Acute and Chronic Myeloid Leukemia Part 2 | Acute and Chronic Myeloid Leukemia Part 3

II. Preview all questions below

1. Normal range for plasma erythropoietin is ?
A. 1 to 11 mU / mL
B. 4 to 26 mU / mL
C. 21 to 54 mU / mL
D. 34 to 90 mU / mL

2. Which of the following is false about polycythemia vera ?
A. Erythroid progenitor cells are resistant to apoptosis
B. Autonomous clonal form of erythrocytosis
C. Elevated plasma erythropoietin level excludes
polycythemia vera as the cause for erythrocytosis
D. Abundant bone marrow iron

3. Thrombosis in polycythemia vera is due to ?
A. Erythrocytosis
B. Leucocytosis
C. Thrombocytosis
D. All of the above

4. Intractable generalized pruritus in polycythemia vera responds to ?
A. Hydroxyurea
B. Interferon (IFN)-
C. PUVA therapy
D. All of the above

5. Drug ‘Anagrelide’ is a ?
A. Phosphodiesterase inhibitor
B. Salicylate isomer
C. Anticoagulant
D. Cytotoxic agent

6. Chronic primary myelofibrosis is characterised by all except ?
A. Jaundice
B. Marrow fibrosis
C. Extramedullary hematopoiesis
D. Splenomegaly

7. JAK2 V617F is present in what percentage of PMF patients ?
A. 10 %
B. 25 %
C. 50 %
D. 75 %

8. Fibrosis and osteosclerosis in PMF is due to ?
A. Overproduction of transforming growth factor
B. Overproduction of tissue inhibitors of metalloproteinases
C. Overproduction of osteoprotegerin
D. All of the above

9. Exuberant extramedullary hematopoiesis can cause which of the following ?
A. Pulmonary hypertension
B. Intracranial hypertension
C. Spinal cord compression
D. All of the above

10. Presence of which of the following establishes the occurrence of extramedullary hematopoiesis ?
A. Teardrop-shaped red cells
B. Nucleated red cells
C. Myelocytes and promyelocytes
D. All of the above

11. In PMF, which of the following is seen ?
A. Antinuclear antibodies
B. Rheumatoid factor
C. Positive Coombs’ test
D. All of the above

12. Which of the following is false about essential thrombocytosis ?
A. Clonal disorder of unknown etiology
B. Female predominance
C. Patients have hemorrhagic & thrombotic tendencies
D. None of the above

13. Disorders that can masquerade as essential thrombocytosis include ?
A. CML
B. Polycythemia vera
C. Myelodysplasia
D. All of the above

14. ‘Mpl’ is the receptor for ?
A. Erythropoietin
B. Granulocyte-macrophage colony-stimulating factor
C. Thrombopoietin
D. All of the above

15. Megakaryocyte receptor of thrombopoietin (TPO) is ?
A. a-mpl
B. b-mpl
C. c-mpl
D. d-mpl

16. Thrombopoietin is produced in ?
A. Liver
B. Pancreas
C. Lungs
D. Thymus

17. Gene for thrombopoietin is located on which chromosome ?
A. 1
B. 2
C. 3
D. 4

18. Bleeding associated with thrombocytosis responds to ?
A. Salicylates
B. IFN-
C. Anagrelide
D. -aminocaproic acid

[MCQs] Acute and Chronic Myeloid Leukemia – Part 2

I. Start the exam by click the “Start” button

Acute and Chronic Myeloid Leukemia- Part 2

II. Preview all questions below

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[MCQs] Acute and Chronic Myeloid Leukemia – Part 1

[MCQs] Acute and Chronic Myeloid Leukemia – Part 3

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