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HORMONE METABOLISM- Part 11
See all quizzes of HORMONE METABOLISM- Part 11 here:
1 Iodide uptake by thyroid gland is decreased
by
(A) Thicyanate (B) Thiouracil
(C) Thiourea (D) Methimazole
2. Binding of growth hormone to its
receptor results in phosphorylation of
(A) JAK-2
(B) Growth hormone receptor
(C) STATs
(D) All of these
3. Binding of growth hormone to its
receptor results in increased transcription
of
(A) c-fos gene (B) c-myc gene
(C) p-53 gene (D) None of these
4. Activation of IRS-1, PI-3 kinase and GRB-
2 is brought about by
(A) Glucagon (B) Insulin
(C) Prolactin (D) IGF-2
5. The protein IRS-1 is phosphorylated by
(A) Protein kinase A
(B) Protein kinase C
(C) Tyrosine kinase activity of insulin receptor
(D) Tyrosine kinase activity of IGF-1 receptor
6. Phosphorylated IRS-1 activates GRB-2
which is
(A) G-protein receptor binding protein-2
(B) Growth factor receptor binding protein-2
(C) Growth hormone receptor binding protein-2
(D) Glucocorticoid receptor binding protein-2
7. STAT proteins are
(A) Thermostat proteins of brain
(B) Glucostat proteins of hepatocyte cell
membrane
(C) Short term activators of translation
(D) Signal transduction and activators of
transcription
8. Activated phospholipase C acts on
(A) Phosphatidyl inositol-4, 5-biphosphate
(B) Inositol-1, 4, 5-triphosphate
(C) Protein kinase C
(D) Pl-3 kinase
9. Phospholipase C is activated by
(A) Gs proteins (B) Gi proteins
(C) Gq proteins (D) G12 proteins
10. Proteoglycans are made up of proteins
and
(A) Glucosamine (B) Mannosamine
(C) Sialic acid (D) Mucopolysaccharides
11 Sweat chlorides are increased in
(A) Cystic fibrosis (B) Pancreatic cancer
(C) Acute pancreatitis (D) None of these
12. All the following statements about cystic
fibrosis are correct except
(A) It is inherited as an autosomal recessive
disease
(B) It affects a number of exocrine glands
(C) It causes increased sweating
(D) Sweat chlorides are above 60 mEq/L in this
disease
13. Radioactive iodine uptake by thyroid
gland 24 hours of a test dose is
(A) 1.5–15% of the test done
(B) 15–20% of the test done
(C) 20–40% of the test done
(D) 50–70% of the test done
14. Radioactive iodine uptake by thyroid
gland is increased in
(A) Endemic goitre (B) Hyperthyroidism
(C) Myxoedema (D) Creatinism
15. Normal range of total thyroxine in serum
is
(A) 0.8–2.4 ng/dl (B) 0.8–2.4 μg/dl
(C) 5–12 ng/dl (D) 5–12 μg/dl
16. Normal range of total tri-iodothyronine
in serum is
(A) 0.1–0.2 ng/dl (B) 0.1–0.2 μg/dl
(C) 0.8–2.4 ng/dl (D) 0.8–2.4 μg/dl
17. Administration of TSH increases serum T3
and T4 in
(A) Hyperthyroidism of pituitary origin
(B) Hyperthyroidism of thyroid origin
(C) Hypothyroidism of pituitary origin
(D) Hypothyroidism of thyroid origin
18. High level of T3 and T4 and low TSH in
serum indicates
(A) Hyperthyroidism of pituitary origin
(B) Hypothyroidism of pituitary origin
(C) Hyperthyroidism of thyroid origin
(D) Hypothyroidism of thyroid origin
19. BMR is increased in
(A) Endemic goitre (B) Thyrotoxicosis
(C) Myxoedema (D) Cretinism
20. Which one of the following statements
correctly describes eukaryotic DNA?
(A) If uses DNA polymerase with nuclease
activities
(B) It is replicated bidirectionally at many points
(C) It contains no repetitive DNA
(D) It is nonlinear
21. Which one of the following causes frame
shift mutation?
(A) Transition
(B) Transversion
(C) Deletion
(D) Substitution of purine to pyrimidine
22. The second messenger for many hormones
is
(A) ATP (B) cyclic AMP
(C) cGMP (D) UTP
23. The most potent hormone concerned witwith
the retention of sodium in the body is
(A) Cortisone (B) Aldosterone
(C) Corticosterone (D) Cortisol
24. Aspirin blocks the synthesis of
(A) Prostaglandins only
(B) Prostacyclins only
(C) Thromboxanes only
(D) All of these
25. Retention of sodium in the body leads to
a retention of
(A) Potassium
(B) Water
(C) Potassium and water
(D) Neither potassium nor water
26. cAMP is so called because it is formed
during
(A) TCA cycle
(B) Urea cycle
(C) Rhodopsin cycle
(D) It has a cyclic structure
27. Protein bound iodine is _________ bound
to protein.
(A) Iodine (B) Thyroid hormones
(C) Thyroxine (D) Tri iodo thyronine
28. In hypophysectonized animals, fasting
produces
(A) Severe hyperglycemia
(B) Hypoglycemia
(C) No change in blood sugar
(D) Mild hyper glycemia
29. Calcitomica is antagonist to
(A) Serotonin
(B) Thyroxine
(C) Tri iodo thyronine
(D) Para thyroid hormone
30. There is polyuria without glycosuria in
this disorder
(A) Diabetes insipidus (B) Diabetes millitus
(C) Bronze diabetes (D) Juvenile diabetes
