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HORMONE METABOLISM- Part 10
See all quizzes of HORMONE METABOLISM- Part 10 here:
1 Excessive secretion of glucocorticoids raises
blood glucose by
(A) Decreasing glycogenesis
(B) Increasing glycogenolysis
(C) Increasing gluconeogenesis
(D) Inhibiting HMP shunt
2. Mineralcorticoids regulate the metabolism
of all of the following except
(A) Sodium (B) Potassium
(C) Calcium (D) Chloride
3. Mineralocorticoids increase the tubular
reabsorption of
(A) Sodium and calcium
(B) Sodium and potassium
(C) Sodium and chloride
(D) Potassium and chloride
4. Mineralocorticoids increase the tubular
secretion of
(A) Sodium (B) Potassium
(C) Chloride (D) Bicarbonate
5. Secretion of mineralcorticoids is increased
by
(A) ACTH (B) Angiotensin
(C) Hypokalaemia (D) Hypernatraemia
6. In Addison’s disease, there is excessive
retention of
(A) Potassium (B) Sodium
(C) Chloride (D) Water
7. In adrenogenital syndrome due to total
absence of 21-hydroxylase in adrenal
cortex, there is
(A) Deficient secretion of glucocorticoids
(B) Deficient secretion of mineralcorticoids
(C) Excessive secretion of androgens
(D) All of these
8. Spironolactone is an antagonist of
(A) Cortisol (B) Hydrocortisone
(C) Aldosterone (D) Testosterone
9. Androgens are synthesised in
(A) Leydig cells in testes
(B) Sertoli cells in testes
(C) Seminiferous tubules
(D) Prostate gland
10. Testosterone is transported in blood by
(A) Transcortin
(B) Testosterone binding globulin
(C) Testosterone estrogen binding globulin
(D) Albumin
11. The metabolites of androgens are
(A) 17-Hydroxysteroids
(B) 17-Ketosteroids
(C) 11-Hydroxysteroids
(D) 11-Ketosteroids
12. An androgen which is more powerful
than testosterone is
(A) Androstenedione (B) Dihydrotestosterone
(C) Androsterone (D) Epiandrosterone
13. Secretion of androgens is increased by
(A) LH (B) FSH
(C) ACTH (D) Growth hormone
14. During late pregnancy, the major source
of progesterone is
(A) Adrenal cortex (B) Placenta
(C) Corpus luteum (D) Graafian follicles
15. Progesterone is transported in blood by
(A) Transcortin
(B) Sex hormone binding globulin
(C) Albumin
(D) Testosterone estrogen binding globulin
16. The major metabolite of progesterone is
(A) Pregnenolone (B) Pregnanediol
(C) Estradiol (D) Norethindrone
17. Secretion of progesterone
(A) Is more in first half of menstrual cycle than in
second half
(B) Is more in second half of menstrual cycle than
in first half
(C) Remains constant during menstrual cycle
(D) Decreases during pregnancy
18. Women become susceptible to osteoporosis
after menopause due to decreased
(A) Secretion of Parathormone
(B) Conversion of vitamin D into calcitriol
(C) Secretion of estrogen
(D) Secretion of progesterone
19. A hormone used for detection of pregnancy
is
(A) Estrogen
(B) Progesterone
(C) Oxytocin
(D) Chorionic gonadotropin
20. Placenta secretes all of the following
except
(A) FSH
(B) Progesterone
(C) Estrogen
(D) Chorionic gonadotropin
21. Gastrin is a polypeptide made up of
(A) Five amino acids
(B) Twelve amino acids
(C) Seventeen amino acids
(D) Twenty amino acids
22. Biological activity of gastrin is present in
the
(A) Four N-terminal amino acids
(B) Four C-terminal amino acids
(C) Five N-terminal amino acids
(D) Five C-terminal amino acids
23. All the following statements about β-
endorphin are true except μ :
(A) It is a polypeptide
(B) Its precursor is pro-opio-melanocortin
(C) Its receptors are represent in brain
(D) Its action is blocked by morphine
24. All the following statements about
epidermal growth factor are true except
(A) It is a protein
(B) It possess quaternary structure
(C) Its receptor is made up of a single polypeptide
chain
(D) Its receptor possesses tyrosine kinase domain
25. Met-enkephalin is a
(A) Tripeptide (B) Pentapeptide
(C) Octapeptide (D) Decapeptide
26. Vasoconstrictor effect of ADH is mediated
by
(A) cAMP (B) cGMP
(C) Protein kinase C (D) Angiotensin II
27. The rate limiting step in catecholamine
synthesis is catalysed by
(A) Phenylalanine hydroxylase
(B) Tyrosine hydroxylase
(C) Dopa decarboxylase
(D) Phenylethanolamine N-methyl transferase
28. Dopa decarboxylase is inhibited by
(A) Epinephrine (B) Norepinephrine
(C) α−Methyldopa (D) None of these
29. Tyrosine hydroxylase is inhibited by
(A) Catecholamines (B) α−Methyldopa
(C) Phenylalanine (D) Vanillyl mandelic acid
30. Urinary excretion of vanillyl madelic acid
is increased in
(A) Phaeochromocytoma
(B) Cushing’s syndrome
(C) Carcinoid syndrome
(D) Aldosteronism
