[MCQ] HIV / AIDS- Part 12

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HIV / AIDS- Part 12

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Congratulations - you have completed HIV / AIDS- Part 12. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

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Question 1

Area under the plasma concentration-time curve of Saquinavir is increased by ?

A	Nelfinavir
B	Indinavir
C	Ritonavir
D	All of the above

Question 2

The most important side effect of Indinavir is ?

A	Nephrolithiasis
B	Peripheral neuropathy
C	Glaucoma
D	Ototoxicity

Question 2 Explanation:

The main side effects of indinavir are nephrolithiasis

Question 3

Which of the following is not a Protease inhibitor ?

A	Indinavir
B	Saquinavir
C	Ritonavir
D	Tenofovir

Question 4

Which of the following is not a NNRTI ?

A	Efavirenz
B	Nevirapine
C	Zalcitabine
D	Delavirdine

Question 5

First drug approved by US FDA for treatment of AIDS is ?

A	Zidovudine
B	Zalcitabine
C	Delavirdine
D	Lamivudine

Question 5 Explanation:

Zidovudine (AZT) was the first drug approved for the treatment of HIV infection and is the prototype nucleoside analogue.

Question 6

Zidovudine was approved by US FDA for treatment of AIDS in ?

A	1983
B	1987
C	1990
D	1995

Question 7

First protease inhibitor used along with zidovudine and lamivudine in “triple combination therapy” for HIV was ?

A	Indinavir
B	Saquinavir
C	Ritonavir
D	Nelfinavir

Question 7 Explanation:

Indinavir was the first protease inhibitor used in combination with dual nucleoside therapy. Combination of zidovudine, lamivudine & indinavir was the first “triple combination” effective on HIV replication.

Question 8

The first HIV-1 protease inhibitors to be licensed was ?

A	Saquinavir
B	Indinavir
C	Ritonavir
D	Nelfinavir

Question 8 Explanation:

Saquinavir was the first HIV-1 protease inhibitors to be licensed.

Question 9

Which of the following protease inhibitors is best-tolerated ?

A	Saquinavir
B	Indinavir
C	Ritonavir
D	Nelfinavir

Question 9 Explanation:

Saquinavir is among the best-tolerated protease inhibitors

Question 10

Which of the following is a fusion inhibitor ?

A	Abacavir
B	Enfuvirtide
C	Efavirenz
D	Tenofovir

Question 11

Which of the following antiretroviral medication is available as an intravenous formulation ?

A	Stavudine
B	Zidovudine
C	Lamivudine
D	Didanosine

Question 12

Which of the following drugs does not require dose adjustment in patients with renal insufficiency ?

A	Abacavir
B	Didanosine
C	Emtricitabine
D	Lamivudine

Question 13

Which of the following drugs does not require dose adjustment in patients with renal insufficiency ?

A	Abacavir
B	Stavudine
C	Zidovudine
D	Lamivudine

Question 13 Explanation:

Tenofovir is contraindicated in patients with renal impairment.

Question 14

Which of the drugs require dose adjustment in patients with hepatic impairment ?

A	Atazanavir
B	Fosamprenavir
C	Indinavir
D	All of the above

Question 15

‘Lactic acidosis syndrome’ is a serious adverse effect of which of the following antiretroviral drug ?

A	Stavudine
B	Didanosine
C	Zidovudine
D	All of the above

Question 15 Explanation:

Lactic acidosis is most commonly seen with nucleoside analogue reverse transcriptase inhibitors.

Question 16

Stevens - Johnson syndrome or toxic epidermal necrosis is a serious adverse effect of which of the following antiretroviral drug ?

A	Stavudine
B	Didanosine
C	Zidovudine
D	Nevirapine

Question 16 Explanation:

In HIV infection Stevens-Johnson syndrome may occur due to nonnucleoside reverse transcriptase inhibitors nevirapine, delavirdine, and efavirenz.

Question 17

Which of the following antiretroviral medications is also active against hepatitis B virus (HBV) ?

A	Lamivudine
B	Emtricitabine
C	Tenofovir
D	All of the above

Question 17 Explanation:

Lamivudine, emtricitabine and tenofovir are used to treat hepatitis B infection in HIV infection

Question 18

Which of the following reverse transcriptase inhibitors are quite selective for the HIV-1 reverse transcriptase ?

A	Nonnucleoside reverse transcriptase inhibitors
B	Nucleoside analogues
C	Nucleotide analogues
D	All of the above

Question 18 Explanation:

Nonnucleoside reverse transcriptase inhibitors are quite selective for the HIV-1 reverse transcriptase, the nucleoside and nucleotide analogues inhibit a variety of DNA polymerization reactions in addition to those of HIV-1 reverse transcriptase. Therefore, serious side effects are more varied with nucleoside analogues & include mitochondrial damage that can lead to hepatic steatosis, lactic acidosis, peripheral neuropathy & and pancreatitis.

Question 19

Pancreatitis is the adverse effect of which of the following ?

A	Didanosine
B	Zalcitabine
C	Stavudine
D	All of the above

Question 20

Among the nucleoside analogues licensed for the treatment of HIV infection, which one is the weakest ?

A	Didanosine
B	Zalcitabine
C	Abacavir
D	Emtricitabine

Question 20 Explanation:

Among nucleoside analogues (zidovudine, didanosine, zalcitabine, stavudine, lamivudine, abacavir & emtricitabine) licensed for the treatment of HIV infection, Zalcitabine is probably the weakest

Question 21

Action of zidovudine is antagonised by ?

A	Didanosine
B	Stavudine
C	Abacavir
D	Emtricitabine

Question 21 Explanation:

Like zidovudine, stavudine is a thymidine analogue. These two drugs are antagonistic in vitro and in vivo and should not be given together

Question 22

Which of the following is the best tolerated & least toxic nucleoside analogue ?

A	Lamivudine
B	Stavudine
C	Zidovudine
D	Emtricitabine

Question 22 Explanation:

Lamivudine is the best tolerated and least toxic nucleoside analogues.

Question 23

Abacavir-resistant strains of HIV are also resistant to ?

A	Lamivudine
B	Didanosine
C	Zalcitabine
D	All of the above

Question 23 Explanation:

Abacavir-resistant strains of HIV are typically also resistant to lamivudine, didanosine & zalcitabine.

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See all quizzes of HIV / AIDS- Part 12 here:

1 Area under the plasma concentration-time curve of Saquinavir is
increased by ?
A. Nelfinavir
B. Indinavir
C. Ritonavir
D. All of the above
2 The most important side effect of Indinavir is ?
A. Nephrolithiasis
B. Peripheral neuropathy
C. Glaucoma
D. Ototoxicity

3 Which of the following is not a Protease inhibitor ?
A. Indinavir
B. Saquinavir
C. Ritonavir
D. Tenofovir
4 Which of the following is not a NNRTI ?
A. Efavirenz
B. Nevirapine
C. Zalcitabine
D. Delavirdine
5 First drug approved by US FDA for treatment of AIDS is ?
A. Zidovudine
B. Zalcitabine
C. Delavirdine
D. Lamivudine

6 Zidovudine was approved by US FDA for treatment of AIDS in ?
A. 1983
B. 1987
C. 1990
D. 1995
7 First protease inhibitor used along with zidovudine and
lamivudine in “triple combination therapy” for HIV was ?
A. Indinavir
B. Saquinavir
C. Ritonavir
D. Nelfinavir

8 The first HIV-1 protease inhibitors to be licensed was ?
A. Saquinavir
B. Indinavir
C. Ritonavir
D. Nelfinavir

9 Which of the following protease inhibitors is best-tolerated ?
A. Saquinavir
B. Indinavir
C. Ritonavir
D. Nelfinavir

10Which of the following is a fusion inhibitor ?
A. Abacavir
B. Enfuvirtide
C. Efavirenz
D. Tenofovir
11 Which of the following antiretroviral medication is available as
an intravenous formulation ?
A. Stavudine
B. Zidovudine
C. Lamivudine
D. Didanosine
12 Which of the following drugs does not require dose adjustment
in patients with renal insufficiency ?
A. Abacavir
B. Didanosine
C. Emtricitabine
D. Lamivudine
13 Which of the following drugs does not require dose adjustment
in patients with renal insufficiency ?
A. Abacavir
B. Stavudine
C. Zidovudine
D. Lamivudine

14 Which of the drugs require dose adjustment in patients with
hepatic impairment ?
A. Atazanavir
B. Fosamprenavir
C. Indinavir
D. All of the above
15 ‘Lactic acidosis syndrome’ is a serious adverse effect of which of
the following antiretroviral drug ?
A. Stavudine
B. Didanosine
C. Zidovudine
D. All of the above

16 Stevens – Johnson syndrome or toxic epidermal necrosis is a serious
adverse effect of which of the following antiretroviral drug ?
A. Stavudine
B. Didanosine
C. Zidovudine
D. Nevirapine

17 Which of the following antiretroviral medications is also active
against hepatitis B virus (HBV) ?
A. Lamivudine
B. Emtricitabine
C. Tenofovir
D. All of the above

18 Which of the following reverse transcriptase inhibitors are quite
selective for the HIV-1 reverse transcriptase ?
A. Nonnucleoside reverse transcriptase inhibitors
B. Nucleoside analogues
C. Nucleotide analogues
D. All of the above

19 Pancreatitis is the adverse effect of which of the following ?
A. Didanosine
B. Zalcitabine
C. Stavudine
D. All of the above
20 Among the nucleoside analogues licensed for the treatment of
HIV infection, which one is the weakest ?
A. Didanosine
B. Zalcitabine
C. Abacavir
D. Emtricitabine

21 Action of zidovudine is antagonised by ?
A. Didanosine
B. Stavudine
C. Abacavir
D. Emtricitabine

22 Which of the following is the best tolerated & least toxic nucleoside
analogue ?
A. Lamivudine
B. Stavudine
C. Zidovudine
D. Emtricitabine

23 Abacavir-resistant strains of HIV are also resistant to ?
A. Lamivudine
B. Didanosine
C. Zalcitabine
D. All of the above

HIV / AIDS

[MCQ] HIV / AIDS- Part 12

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HIV / AIDS- Part 12

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