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ENZYMES- Part 9
See all quizzes of ENZYMES- Part 8 here:
1. Cholesterol by a feed back mechanism
inhibits the activity of
(A) HMG-CoA synthetase
(B) HMG-CoA reductase
(C) Thilase
(D) Mevalonate kinase
2. The activity of HMG-CoA reductase is
inhibited by
(A) A fungal inhibitor mevastatin
(B) Probucol
(C) Nicotinic acid
(D) Clofibrate
3. Hypolipidemic drugs reduce serum
cholesterol and triacylglycerol. The effect
of clofibrate is attributed to
(A) Block in absorption from G.I.T.
(B) Decrease in secretion of triacylglycerol and
cholesterol containing VLDL by liver
(C) Block in the reabsorption of bile acids
(D) Decreased synthesis of cholesterol
4. In biosynthesis of cholesterol triparanol
inhibits the activity of the enzyme:
(A) Δ24 Reductase
(B) Oxidosqualene-lanosterol cyclase
(C) Isomerase
(D) Squalene epoxidase
5. HMG-CoA reductase activity is increased
by administration of the hormone:
(A) Insulin (B) Glucagon
(C) Epinephrine (D) Glucocorticoids
6. The principal sterol excreted in feces is
(A) Coprostanol (B) Zymosterol
(C) Lanosterol (D) Desmosterol
7. The principal rate limiting step in the
biosynthesis of bile acids is at the
(A) 7-Hydroxylase reaction
(B) 12 α-Hydroxylase reaction
(C) Conjugation reaction
(D) Deconjugation reaction
8. Hypercholesterolemia is found in
(A) Xanthomatosis
(B) Thyrotoxicosis
(C) Hemolytic jaundice
(D) Malabsorption syndrom
9. Hypocholesterolemia is found in
(A) Thyrotoxicosis
(B) Diabetes mellitus
(C) Obstructive jaundice
(D) Nephrotic syndrome
10. The major source of extracellular
cholesterol for human tissue is
(A) Very low density lipoprotein
(B) High density lipoprotein
(C) Low density lipoprotein
(D) Albumin
11. Correct ordering of lipoprotein molecules
from lowest to the greater density is
(A) LDL, IDL, VLDL, chylomicron
(B) Chylomicron, VLDL, IDL, LDL
(C) VLDL, IDL, LDL, chylomicron
(D) LDL, VLDL, IDL, chylomicron
12. In Hurler’s syndrome, urine shows the
presence of
(A) Keratan sulphate I
(B) Chondroitin sulphate
(C) Dermatan sulphate and heparan sulphate
(D) Keratan sulphate II
13. Defective enzyme in Hunter’s syndrome
is
(A) α-L-iduronidase (B) Iduronate sulphatase
(C) Arylsulphatase B (D) C-acetyl transferase
14. In Hunter’s syndrome
(A) There is progressive corneal opacity
(B) Keratan sulphate is excreted in the urine
(C) Enzyme defective is arylsulphatase B
(D) Hearing loss is perceptive
15. An important feature of Von-Gierke’s
disease is
(A) Muscle cramps (B) Cardiac failure
(C) Hypoglycemia (D) Respiratory alkalosis
16. The affected organ in Mc Ardle’s syndrome
is
(A) Liver (B) Kidney
(C) Liver and Heart (D) Skeletal muscle
17. Refsum’s disease is due to deficiency of
the enzyme:
(A) Pytantate-α-oxidase
(B) Glucocerebrosidase
(C) Galactocerebrosidase
(D) Ceramide trihexosidase
18. An important finding in Refsum’s disease
is
(A) Accumulation of ceramide trihexoside in the
kidney
(B) Accumulation of phytanic acid in the blood
and tissues
(C) Accumulation of gangliosides in brain and
spleen
(D) Skin eruptions
19. α-Galactosidase enzyme is defective in
(A) Tay-sach’s disease
(B) Refsum’s disease
(C) Sandhoff’s disease
(D) Fabry’s disease
20. The hypothesis to explain enzyme–
substrate complex formation:
(A) Lock and key model
(B) Induced fit theory
(C) Proenzyme theory
(D) Both (A) and (B)
21. An important finding in Tay-sach’s disease is
(A) Renal failure
(B) Accumulation of gangliosides in brain and
spleen
(C) Cardiac failure
(D) Anemia
22. The enzyme deficient in Krabbe’s disease is
(A) Hexosaminidase A (B) Arylsuphatase A
(C) β-Galactosidase (D) α-Fucosidase
23. The enzyme ceramidase is deficient in
(A) Farber’s disease (B) Fabry’s disease
(C) Sandhoff’s disease(D) Refsum’s disease
24. Niemann-Pick disease is due to deficiency
of the enzyme
(A) Ceramidase
(B) Glucocerebrosidase
(C) Galactocerebrosidase
(D) Sphingomyelinase
25. Wolman’s disease is due to deficiency of
(A) Cholesteryl ester hydrolase
(B) Hexosaminidase A
(C) α-Fucosidase
(D) Arylsulphatase A
26. The enzyme deficient in Sandhoff’s disease
is
(A) α-Fucosidase
(B) Hexosaminidase A and B
(C) β-Galactosidase
(D) β-Glucosidase
27. Jamaican vomiting sickness is due to
inactivation of the enzyme
(A) Pyruvate carboxylase
(B) Acyl-Co-A synthetase
(C) Acyl-Co-A dehydrogense
(D) Thiolase
28. Zellweger’s syndrome is due to inherited
absence of
(A) Peroxisomes
(B) Phospholipase A1
(C) Acyl-Co-A dehydrogenase
(D) Thiolase
29. Bassen-Kornzweig syndrome is due to
(A) Absence of Apo-C-II
(B) Defect in Apo-B synthesis
(C) Absence of Apo-E
(D) Absence of Apo-D
30. Enzyme deficient in Hyperammonemia
type II is
(A) Glutamine synthetase
(B) Glutaminase
(C) Ornithine transcarbamoylase
(D) Carbamoylphosphate synthetase
