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NUCLEIC ACIDS- Part 17
See all quizzes of NUCLEIC ACIDS- Part 17 here:
1 Retinoblastoma can result from a mutation
in
(A) ras proto-oncogene
(B) erbB proto-oncogene
(C) p 53 gene
(D) RB 1 gene
2 All the following statements about retino
blastoma are true except
(A) At least two mutations are required for its
development
(B) One mutation can be inherited from a parent
(C) Children who have inherited one mutation
develop retinoblastoma at a younger age
(D) RB 1 gene promotes the development of
retinoblastoma
3. Ames assay is a rapid method for detection
of
(A) Oncoviruses
(B) Retroviuses
(C) Chemical carcinogens
(D) Typhoid
4. Amplification of dihydrofolate reductase
gene in a cancer cell makes the cell
(A) Susceptible to folic acid deficiency
(B) Less malignant
(C) Resistant to amethopterin therapy
(D) Responsive to amethopterin therapy
5. Conversion of a procarcinogen into a
carcinogen often requires
(A) Proteolysis
(B) Microsomal hydroxylation
(C) Exposure to ultraviolet radiation
(D) Exposure to X-rays
6. The only correct statement about oncoviruses
is
(A) All the oncoviruses are RNA viruses
(B) Reverse transcriptase is present in all
oncoviruses
(C) Viral oncogenes are identical to human
protooncogens
(D) Both DNA and RNA viruses can be
oncoviruses
7. RB 1 gene is
(A) A tumour suppressor gene
(B) Oncogene
(C) Proto-oncogene
(D) Activated proto-oncogene
8. Cancer cells may become resistant to
amethopterin by
(A) Developing mechanisms to destroy amethopterin
(B) Amplification of dihydrofolate reducatse gene
(C) Mutation in the dihydrofolate reductase gene
so that the enzyme is no longer inhibited by
amethopterin
(D) Developing alternate pathway of thymidylate
synthesis
9. The major source of NH3 produced by the
kidney is
(A) Leucine (B) Glycine
(C) Alanine (D) Glutamine
10. Which of these methyl donors is not a
quanternary ammonium compound?
(A) Methionine (B) Choline
(C) Betain (D) Betainaldehyde
11. L-glutamic acid is subjected to oxidative
deaminition by
(A) L-amino acid dehydrogenase
(B) L-glutamate dehydrogenase
(C) Glutaminase
(D) Glutamine synthetase
12. A prokaryotic ribosome is made up of
________ sub units.
(A) 20 S and 50S (B) 30S and 50S
(C) 30S and 60S (D) 20S and 50S
13. AN Eukaryotic ribosome is made up of
________ sub unit.
(A) 40S and 60S (B) 40S and 50S
(C) 40S and 80S (D) 60S and 80S
14. GTP is not required for
(A) Capping L of mRNA
(B) Fusion of 40S and 60S of ribosome
(C) Accommodation of tRNA amino acid
(D) Formation of tRNA amino acid complex
15. The antibiotic which inhibits DNA
dependent RNA polymerase is
(A) Mitomycin C (B) Actinomycin d
(C) Streptomycin (D) Puromycin
16. The antibiotic which cleaves DNA is
(A) Actinomycin d (B) Streptomycin
(C) Puromycin (D) Mitomycin C
17. The antibiotic which has a structure similar
to the amino acyl end of tRNA tyrosine is
(A) Actinomycin d (B) Streptomycin
(C) Puromycin (D) Mitomycin c
18. ATP is required for
(A) Fusion of 40S and 60S of ribosome
(B) Accommodation tRNA amino acid in a site of
ribosome
(C) Movement of ribosome along mRNA
(D) formation of tRNA amino acid complex
19. What is the subcellular site for the biosynthesis
of proteins?
(A) Chromosomes (B) Lymosomes
(C) Ribosomes (D) Centrosomes
20. An animal is in negative nitrogen balance
when
(A) Intake exceeds output
(B) New tissue is being synthesized
(C) Output exceeds intake
(D) Intake is equal to output
21. When NH3 is perfused through a dog’s
liver ______ is formed, while ______ is
formed in the birds liver.
(A) Urea, Uric acid (B) Urea, allantoin
(C) Uric acid, creatinine
(D) Uric acid, Urea
22. Aspartate amino transferase uses the
following for transamination:
(A) Glutamic acid and pyruvic acid
(B) Glutamic acid and oxaloacetic acid
(C) Aspartic acid and pyruvic acid
(D) aspartic acid and keto adipic acid
23. Which among the following compounds
is not a protein?
(A) Insulin (B) Hheparin
(C) Mucin (D) Pepsin
24. Almost all the urea is formed in this tissue:
(A) Kidney (B) Urethra
(C) Uterus (D) Liver
25. A polyribosome will have about _______
individual ribosomes.
(A) 20 (B) 10
(C) 5 (D) 2
26. Progressive transmethylation of ethanolamine
gives
(A) Creatinine
(B) Choline
(C) Methionine
(D) N-methyl nicotinamide
27. Genetic information originates from
(A) Cistron of DNA
(B) Codons of mRNA
(C) Anticodons of tRNA
(D) Histones of nucleoproteins
28. The genetic code operates through
(A) The protein moiety of DNA
(B) Cistrom of DNA
(C) Nucleotide sequence of m RNA
(D) The anticodons of tRNA
29. DNA synthesis in laboratory was first
achieved by
(A) Watson and crick (B) Khorana
(C) A.Kornberg (D) Ochoa
30. Among the different types of RNA, which
one has the highest M.W.?
(A) mRNA (B) rRNA
(C) yeast RNA (D) tRNA
