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MINERAL METABOLISM- Part 2
See all quizzes of MINERAL METABOLISM- Part 2 here:
1 Activity of cytochrome oxidase is inhibited
by
(A) Sulphite (B) Sulphate
(C) Arsenite (D) Cyanide
2. Transfer of reducing equivalents from
succinate dehydrogenase to coenzyme Q
is specifically inhibited by
(A) Carboxin (B) Oligomycin
(C) Piericidin A (D) Rotenone
3. Chemiosmotic theory for oxidative
phosphorylation has been proposed by
(A) Chance and Williams
(B) Pauling and Corey
(C) S. Waugh
(D) P. Mitchell
4. The number of ATP produced in the
oxidation of 1 molecule of NADPH in
oxidative phosphorylation is
(A) Zero (B) 2
(C) 3 (D) 4
5. The coupling of oxidation and phosphorylation
in intact mitochondria:
(A) Puromycin (B) Oligomycin
(C) Streptomycin (D) Gentamycin
6. An uncoupler of oxidative phosphorylation
is
(A) Carboxin (B) Atractyloside
(C) Amobarbital (D) Dinitrocresol
7. The chemical inhibiting oxidative phosphorylation,
Adependent on the transport
of adenine nucleotides across the inner
mitochondrial membrane is
(A) Oligomycin (B) Atractyloside
(C) Dinitrophenol (D) Pentachlorophenol
8. Porphyrins are synthesized in
(A) Cytosol
(B) Mitochondria
(C) Cytosol and mitochondria
(D) Rough endoplasmic reticulum
9. Heme is synthesized from
(A) Succinyl-CoA and glycine
(B) Active acetate and glycine
(C) Active succinate and alanine
(D) Active acetate and alanine
10. In the biosynthesis of the iron protoporphyrin,
the product of the condensation
between succinyl-CoA and glycine is
(A) α-Amino β-ketoadipic acid
(B) δ-Aminolevulinate
(C) Hydroxymethylbilane
(D) Uroporphyrinogen I
11. Porphyrin synthesis is inhibited in
(A) Mercury poisoning
(B) Lead poisoning
(C) Manganese poisoning
(D) Barium poisoning
12. During synthesis of porphyrins, synthesis
of δ-amino levulinic acid occurs in
(A) Mitochondria
(B) Cytosol
(C) Both in mitochondria and cytosol
(D) Ribosomes
13. In the biosynthesis of heme, condensation
between succinyl CoA and glycine requires
(A) NAD+ (B) FAD
(C) NADH + H+ (D) B6-phosphate
14. In mammalian liver the rate controlling
enzyme in porphyrin biosynthesis is
(A) ALA synthase
(B) ALA hydratase
(C) Uroporphyrinogen I synthase
(D) Uroporphyrinogen III cosynthase
15. The condensation of 2 molecules of
δ-aminolevulinate dehydratase contains
(A) ALA synthase
(B) ALA hydratase
(C) Uroporphyrinogen synthase I
(D) Uroporphyrinogen synthase III
16. The enzyme δ-aminolevulinate dehydratase
contains
(A) Zinc (B) Manganese
(C) Magnesium (D) Calcium
17. A cofactor required for the activity of the
enzyme ALA dehydratase is
(A) Cu (B) Mn
(C) Mg (D) Fe
18. The number of molecules of porphobilinogen
required for the formation of a tetrapyrrole
i.e., a porphyrin is
(A) 1 (B) 2
(C) 3 (D) 4
19. Conversion of the linear tetrapyrrole
hydroxymethylbilane to uroporphyrinogen
III
(A) Occurs spontaneously
(B) Catalysed by uroporphyrinogen I synthase
(C) Catalysed by uroporphyrinogen III cosynthase
(D) Catalysed by combined action of uroporphyrinogen
I synthase and uroporphyrinogen III
cosynthase
20. Conversion of uroporphyrinogen III to
coprophyrinogen III is catalysed by the
enzyme.:
(A) Uroporphyrinogen decarboxylase
(B) Coproporphyrinogen oxidase
(C) Protoporphyrinogen oxidase
(D) Ferrochelatase
21. The synthesis of heme from protophyrin
III is catalysed by the enzyme:
(A) ALA synthase (B) Ferroreductase
(C) Ferrooxidase (D) Ferrochelatase
22. Many xenobiotics
(A) Increase hepatic ALA synthase
(B) Decrease hepatic ALA sythase
(C) Increase hepatic ALA dehydrase
(D) Decrease hepatic ALA dehydrase
23. Acute intermittent porphyria (paraoxymal
porphyria) is caused due to deficiency of
(A) Uroporphyrinogen I synthase
(B) ALA synthase
(C) Coproporphyrinogen oxidase
(D) Uroporphyrinogen decarboxylase
24. The major symptom of acute intermittent
porphyria includes
(A) Abdominal pain
(B) Photosensitivity
(C) No neuropsychiatric signs
(D) Dermatitis
25. The characteristic urinary finding in acute
intermittent porphyria is
(A) Increased quantity of uroporphyrin
(B) Increased quantity of coproporphyrin I
(C) Increased quantity of coproporphyrin III
(D) Massive quantities of porphobilinogen
26. The enzyme involved in congenial erythropoietic
porphyria is
(A) Uroporphyrinogen I synthase
(B) Uroporphyrinogen III cosynthase
(C) Protoporphyrinogen oxidase
(D) Ferrochelatase
27. Main symptoms of congenital erythropoietic
porphyria is
(A) Yellowish teeth (B) Photosensitivity
(C) Abdominal pain (D) Brownish urine
28. The probable cause of porphyria cutanea
tarda is deficiency of
(A) Uroporphyrinogen oxidase
(B) Coproporphyrinogen oxidase
(C) Protoporphyrinogen oxidase
(D) Uroporphyrinogen I synthase
29. The characteristic urinary finding in porphyria
cutanea tarda is
(A) Increased quantity of porphobilinogen
(B) Increased quantity of red cell protoporphyrin
(C) Increased quantity of uroporphyrin
(D) Increased quantity of δ-ALA
30. Hereditary coproporphyria is caused due
to deficiency of
(A) Protoporphyrinogen oxidase
(B) ALA synthase
(C) ALA dehydratase
(D) Coproporphyrinogen oxidase
