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FATS AND FATTY ACID METABOLISM- Part 16
See all quizzes of FATS AND FATTY ACID METABOLISM- Part 16 here:
1 Fatty acids can not be converted into
carbohydrates in the body, as the
following reaction is not possible:
(A) Conversion of glucose-6-phosphate into
glucose
(B) Fructose 1, 6 diphosphate to fructose-6-
phosphate
(C) Transformation of acetyl CoA to pyruvate
(D) Formation of acetyl CoA from fatty acids
2. Cholesterol circulates in blood stream
chiefly as
(A) Free cholesterol
(B) Ester cholesterol
(C) Low density lipoproteins
(D) Low density lipoproteins and high density
lipoproteins
3. What is the sub cellular site for the β-
oxidation of fatty acids?
(A) Nucleus (B) Mitochondria
(C) Lysosome (D) Cytosol
4. A diet containing this fat is helpful in
lowering the blood cholesterol level.
(A) Unsaturated (B) Saturated
(C) Vitamin enriched (D) Refined
5. Phospholipase A2 is an enzyme which
removes a fatty acid residue from lecithin
to form
(A) Lecithin fragments
(B) Phosphotidic acid
(C) Glyceryl phosphate
(D) Lysolecithin
6. Pancreatic lipose is an enzyme which
hydrolyzes facts. It acts as a/an
(A) peptidase (B) hydrolase
(C) carbohydrates (D) dehydrogenase
7. This interferes with cholesterol absorption
(A) Lipoprotein lipase
(B) Creatinase
(C) 7-dehydrocholesterol
(D) β-sitosterol
8. The carbon chain of fatty acids is shortened
by 2 carbon atoms at a time. This involves
successive reactions catalysed by 4-enzymes.
These act the following order:
(A) Acetyl CoA dehydrogenase, β-OH acyl CoA
dehydrogenase, enoyl hydrase, thiolose
(B) Acyl CoA dehydrogenase, thiolase, enoyl
hydrase, β-OH acyl CoA dehydrogenase
(C) Acyl CoA dehydrogenase, thiolose, enoyl
hydrase, β-OH acyl CoA dehydrogenase
(D) Enoyl hydrase, β-OH acyl CoA dehydrogenase,
acyl CoA dehydrogenase, thiolose,
9. Acyl carrier protein is involved in the
synthesis of
(A) protein
(B) glycogen
(C) fatty acid outside the mitochondria
(D) fatty acid in the mitochondria
10. 1 molecule of palmitic acid on total
oxidation to CO2 will yield molecules of
ATP (as high energy bonds):
(A) 129 (B) 154
(C) 83 (D) 25
11. HMG CoA is formed in the metabolism of
(A) Cholesterol, ketones and leucine
(B) Cholesterol, fatty acid and Leucine
(C) Lysine, Lecuine and Isoleucine
(D) Ketones, Leucine and Lysine
12. NADPH is produced when this enzyme
acts
(A) Pyruvate dehydrogenase
(B) Malic enzyme
(C) Succinate dehydrogenase
(D) Malate dehydrogenase
13. As a result of each oxidation a long chain
fatty acid is cleaved to give
(A) An acid with 3-carbon less and propionyl CoA
(B) An acid with 2-carbon less and acetyl CoA
(C) An acid with 2-carbon less and acetyl CoA
(D) An acid with 4-carbon and butyryl CoA
14. Liposomes are
(A) Lipid bilayered (B) Water in the middle
(C) Carriers of drugs (D) All of these
15. Long chain fatty acyl CoA esters are
transported across the mitochondrial
membrane by
(A) cAMP (B) Prostaglandin
(C) Carnitine (D) Choline
16. The acetyl CoA formed on β-oxidation of
all long chain fatty acids is metabolized
under normal circumstances to
(A) CO2 and water (B) Cholesterol
(C) Fatty acids (D) Ketone bodies
17. Very low density lipoproteins are relatively
rich in
(A) Cholesterol (B) Triacyl glycerol
(C) Free fatty acids (D) Phospholipids
18. Neutral fat is stored in
(A) Liver (B) Pancreas
(C) Adipose tissue (D) Brain
19. A pathway that requires NADPH as a
cofactor is
(A) Fatty acid oxidation
(B) Extra mitochondrial denovo fatty acid
synthesis
(C) Ketone bodies formation
(D) Glycogenesis
20. The ‘Committed step’ in the biosynthesis
of cholesterol from acetyl CoA is
(A) Formation of acetoacetyl CoA from acetyl CoA
(B) Formation of mevalonate from HMG CoA
(C) Formation of HMG CoA from acetyl CoA and
acetoacetyl CoA
(D) Formation of squalene by squalene synthetase
21. In β-Oxidation of fatty acids, which of the
following are utilized as coenzymes?
(A) NAD+ and NADP+
(B) FADH2 and NADH + H+
(C) FAD and FMN
(D) FAD and NAD+
22. The most important source of reducing
equivalents for FA synthesis on the liver
is
(A) Glycolysis
(B) HMP-Shunt
(C) TCA cycle
(D) Uronic acid pathway
23. All of the following tissue are capable of
using ketone bodies except
(A) Brain (B) Renal cortex
(C) R.B.C. (D) Cardiac muscle
24. The major source of cholesterol in arterial
smooth muscle cells is from
(A) IDL (B) LDL
(C) HDL (D) Chylomicrons
25. Ketone bodies are synthesized from fatty
acid oxidation products by which of the
following organs?
(A) Liver (B) Skeletal muscles
(C) Kidney (D) Brain
26. Chain elongation of fatty acids occurring
in mammalian liver takes place in which
of the following subcellular fractions of
the cell?
(A) Nucleus (B) Ribosomes
(C) Lysosomes (D) Microsomes
27. Which of the following cofactors or their
derivatives must be present for the
conversion of acetyl CoA to malonyl CoA
extramitochondrial fatty acid synthesis?
(A) Biotin (B) FAD
(C) FMN (D) ACP
28. Which of the following statement regarding
β-oxidation is true?
(A) Requires β-ketoacyl CoA as a substrate
(B) Forms CoA thioesters
(C) Requires GTP for its activity
(D) Yields acetyl CoA as a product
29. All statements regarding 3-OH-3 methyl
glutaryl CoA are true except
(A) It is formed in the cytoplasm
(B) Required in ketogenesis
(C) Involved in synthesis of Fatty acid
(D) An intermediate in cholesterol biosynthesis
30. Which of the following lipoproteins
would contribute to a measurement of
plasma cholesterol in a normal individual
following a 12 hr fast?
(A) Chylomicrons
(B) VLDL
(C) Both VLDL and LDL
(D) LDL
