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Chronic Myeloid Leukemia (CML)- Part 1
See all quizzes of the Chronic Myeloid Leukemia (CML) at here:
Chronic Myeloid Leukemia (CML) – Part 1 | Chronic Myeloid Leukemia (CML) – Part 2
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1. Which of the following is false about CML ?
A. Incidence is 1.5 per 100,000 people per year
B. Incidence is higher in men than in women
C. Incidence decreased slightly between 1973 and 1991
D. None of the above
2. Incidence of CML increases slowly with age until mid forties, when it starts to ?
A. Fall rapidly
B. Rise rapidly
C. Remains the same
D. Any of the above
3. In CML, there occurs a reciprocal translocation between ?
A. Chromosomes 5 and 18
B. Chromosomes 7 and 20
C. Chromosomes 9 and 22
D. Chromosomes 11 and 22
4. “BCR” stands for ?
A. Bridgepoint cluster region
B. Breakpoint cluster region
C. Bilateral cluster region
D. Big cluster region
5. “ABL” is named after ?
A. Abelson murine leukemia virus
B. Anderson murine leukemia virus
C. Atkin murine leukemia virus
D. Ashley murine leukemia virus
ABL is named after abelson murine leukemia virus gene.
6. In CML, nature of fusion of BCR gene ABL gene is ?
A. Head-to-tail
B. Tail-to-head
C. Side-to-side
D. Any of the above
7. Untreated CML, goes into blast crisis in a median time of ?
A. 1 year
B. 2 years
C. 3 years
D. 4 years
8. ABL proto-oncogene is present on ?
A. Chromosome 9
B. Chromosome 22
C. Chromosome 11
D. Chromosome 12
9. Breakpoint cluster region (BCR) gene is present on ?
A. Chromosome 9
B. Chromosome 22
C. Chromosome 11
D. Chromosome 12
10. ABL-BCR fusion gene is present on ?
A. Chromosome 9q+
B. Chromosome 22
C. Chromosome 11
D. Chromosome 12
11. ABL-BCR fusion protein is found in ?
A. Nucleus
B. Cytoplasm
C. Cell membrane
D. Nuclear membrane
12. Progression of CML to blast crisis is accelerated by ?
A. Alcohol ingestion
B. Cigarette smoking
C. Exercise
D. Lack of sleep
13. Which of the following about CML is false ?
A. Reciprocal translocation between chromosomes 9 & 22
B. Bcr/Abl fusion protein is p210BCR/ABL
C. Chromosomal instability is a rule
D. There is direct evidence of a viral etiology
14. Which of the following is the most common physical finding in CML ?
A. Splenomegaly
B. Hepatomegaly
C. Lymphadenopathy
D. Bony tenderness
15. In CML, presence of which of the following points towards poor prognosis ?
A. Splenomegaly
B. Hepatomegaly
C. Lymphadenopathy
D. Bony tenderness
16. Which of the following is false about CML ?
A. Platelet counts are always elevated at diagnosis
B. Leukocyte alkaline phosphatase is low
C. Serum vitamin B12 & B12–binding proteins are raised
D. None of the above
17. In CML, disease acceleration is defined by ?
A. Increasing anemia
B. Cytogenetic clonal evolution
C. Blood or marrow blasts between 10 and 20%, blood or
marrow basophils >=20 %, or platelet count <100,000/µL
D. All of the above
18. In CML, blast crisis is defined as blood or marrow blasts more than ?
A. > 5 %
B. > 10 %
C. > 15 %
D. > 20 %
19. Cytogenetic hallmark of CML is ?
A. t(9;22)
B. t(12;22)
C. t(11;14)
D. t(10;17)
20. Philadelphia chromosome can be addressed as ?
A. Shortened chromosome 22 (22q-)
B. Shortened chromosome 9 (9q-)
C. Lengthened chromosome 22 (22q+)
D. Lengthened chromosome 9 (9q+)
21. In classic CML patients, Philadelphia chromosome is present in approximately ?
A. 75 percent
B. 85 percent
C. 95 percent
D. 100 percent
22. Ph chromosome is present in ?
A. All dividing cells of hematopoietic lineage
B. B cells
C. T cells
D. All of the above
23. The human genome contains about ?
A. 70 tyrosine kinases (TK)
B. 80 tyrosine kinases (TK)
C. 90 tyrosine kinases (TK)
D. 100 tyrosine kinases (TK)
