[MCQs] Acute and Chronic Myeloid Leukemia - Part 1

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Acute and Chronic Myeloid Leukemia- Part 1

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Question 1

Which of the following is a characteristic feature of myeloproliferative disorders (MPDs) ?

A	Marrow hypercellularity
B	Thrombosis & hemorrhage
C	Risk of leukemic transformation in long term
D	All of the above

Question 1 Explanation:

Myeloproliferative disorders share many characteristics like marrow hypercellularity, propensity to thrombosis & hemorrhage, and a risk of leukemic transformation in the long term.

Question 2

Which of the following is a Philadelphia (Ph) negative myeloproliferative disorder ?

A	Polycythemia vera
B	Essential thrombocythemia
C	Idiopathic myelofibrosis
D	All of the above

Question 2 Explanation:

The three main Ph-negative myeloproliferative disorders are polycythemia vera, essential thrombocythemia and idiopathic myelofibrosis.

Question 3

Which of the following conditions can transform into each other ?

A	Polycythemia vera (PV)
B	Primary myelofibrosis (PMF)
C	Essential thrombocytosis (ET)
D	All of the above

Question 3 Explanation:

PV, PMF and ET are capable of transforming into each other. Transformation to acute leukemia is uncommon.

Question 4

Which of the following conditions can transform into each other ?

A	Chronic myelogenous leukemia (CML)
B	Chronic neutrophilic leukemia (CNL)
C	Chronic eosinophilic leukemia (CEL)
D	None of the above

Question 4 Explanation:

CML, CNL and CEL cannot transform into each other. But all three have a high rate of transformation into acute leukemia

Question 5

Which of the following about polycythemia vera is false ?

A	Clonal disorder
B	Increased phenotypically normal RBC, WBC & platelets
C	Absence of recognizable physiologic stimulus
D	None of the above

Question 6

Which of the following illustrates the mutation in JAK2 in the pathogenesis of PV ?

A	F617V
B	F716V
C	V617F
D	V716F

Question 6 Explanation:

Mutation in tyrosine kinase JAK2 - replaces valine with phenylalanine (V617F) causes its constitutive activation (erythropoietin-independent) is central in the pathogenesis of PV. Gain-offunction JAK2 mutations underlie polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis (MF).

Question 7

Which out of the following do not use the JAK-STAT pathway as their essential mode of signaling ?

A	Erythropoietin
B	Interleukins 1
C	Thrombopoietin
D	Growth hormone

Question 7 Explanation:

Erythropoietin, thrombopoietin, growth hormone, prolactin, and leptin use JAK-STAT pathway. Tumor necrosis factor, interleukins 1 and 8, transforming growth factor  and macrophage colonystimulating factor do not use the JAK-STAT pathway as their essential mode of signaling

Question 8

Which of the following is a member of Janus kinases ( JAKs) ?

A	Tyrosine kinase 2 (TYK2)
B	JAK1
C	JAK2
D	All of the above

Question 8 Explanation:

There are four JAKs: JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2). All JAKs selectively associate with cytoplasmic domains of various cytokine receptors. JAK3 & TYK2 are primarily important for immune responses. JAK1 & JAK2 have roles that range from host defense and hematopoiesis to growth and neural development

Question 9

Which of the following about signal transducer and activator of transcription (STAT) is false ?

A	DNA-binding proteins
B	Translocate to the nucleus
C	Regulate gene expressio
D	None of the above

Question 9 Explanation:

Cytokine (interferon-, interferon-, and interferon-, erythropoietin, growth hormone, interleukin- 2, interleukin-6, interleukin-7) binding activates JAKs, which in turn phosphorylate cytokine receptors. This process allows the selective binding of members of the STAT family: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6. These DNA-binding proteins become tyrosine-phosphorylated, which allows them to dimerize, translocate to the nucleus, and regulate gene expression.

Question 10

JAK3 associates with which of the following cytokine receptors ?

A	Interleukin-1R chain
B	Interleukin-2R chain
C	Interleukin-3R chain
D	Interleukin-4R chain

Question 10 Explanation:

Activated JAKs phosphorylate (P) and activate STATs and other pathways. Some JAKs are associated with many different cytokine receptors, but JAK3 associates with only one subunit, the common interleukin-2R chain, or c. Loss-of-function mutations of the genes encoding c and JAK3 result in severe combined immunodeficiency (SCID). Mutation of TYK2 also results in immunodeficiency

Question 11

JAK2 mutations are associated with which of the following ?

A	Polycythemia vera
B	Essential thrombocythemia
C	Primary myelofibrosis
D	All of the above

Question 11 Explanation:

JAK2 mutations are associated with myeloproliferative neoplasms, clonal cancers arising from hematopoietic progenitor cells, which include polycythemia vera, essential thrombocythemia, and primary myelofibrosis

Question 12

Loss-of-function mutations of STAT3 result in ?

A	Susceptibility to mycobacteria
B	Chronic mucocutaneous candidiasis
C	Hyper-IgE syndrome or Job’s syndrome
D	All of the above

Question 12 Explanation:

Gain-of-function JAK2 mutations underlie polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis (MF). Autosomal dominant loss-of-function mutations of STAT1 result in susceptibility to mycobacteria only. Autosomal recessive mutations of STAT1 cause susceptibility to mycobacteria and viruses. Autosomal dominant gain-of function mutations of STAT1 cause chronic mucocutaneous candidiasis, and aneurysms. Loss-of-function mutations of STAT3 result in the hyper-IgE syndrome. Mutations in STAT3 also cause large granular lymphocytic (LGL) leukemia. Constitutive STAT3 and STAT5 activation is associated with many cancers. Mutations of STAT5B result in a syndrome characterized by dwarfism and autoimmunity.

Question 13

Polymorphisms of STAT3 are associated with which of the following ?

A	Ankylosing spondylitis
B	Rheumatoid arthritis
C	Systemic lupus erythematosus
D	Allergic disease

Question 13 Explanation:

Polymorphisms of STAT3 are associated with ankylosing spondylitis, polymorphisms of STAT4 are associated with rheumatoid arthritis, systemic lupus erythematosus, and other autoimmune diseases and polymorphisms of STAT6 are associated with allergic disease.

Question 14

Which of the following is a JAK inhibitor ?

A	Ruxolitinib
B	Baricitinib
C	Tofacitinib
D	All of the above

Question 14 Explanation:

All of the above

Question 15

JAK2 gene is located on the ?

A	Short arm of chromosome 9
B	Long arm of chromosome 9
C	Short arm of chromosome 10
D	Long arm of chromosome 10

Question 15 Explanation:

JAK2 gene is located on the short arm of chromosome 9. Loss of heterozygosity on chromosome 9p, due to mitotic recombination is the most common cytogenetic abnormality in PV

Question 16

Which of the following is false about Janus kinase 2 (JAK2) ?

A	Nuclear tyrosine kinase
B	Intracellular signaling by receptors for erythropoietin
C	Intracellular signaling by receptors for GM-CSF
D	Intracellular signaling by receptors for GM-CSF

Question 16 Explanation:

Intracellular signaling by receptors for GM-CSF

Question 17

Which of the following is false in the pathogenesis of PV ?

A	Erythropoietin-independent erythroid colony formation
B	Hypersensitivity of PV erythroid progenitor cells to EPO
C	Resistance of PV erythroid progenitor cells to apoptosis
D	None of the above

Question 17 Explanation:

None of the above

Question 18

Which of the following typically distinguishes polycythemia vera from other causes of erythrocytosis ?

A	Massive splenomegaly
B	High hemoglobin
C	High hematocrit
D	Aquagenic pruritus

Question 18 Explanation:

Splenomegaly, high Hb, high PCV, hyperviscosity leading to venous or arterial thrombosis, systolic hypertension, erythromelalgia, gout, uric acid stones are features of PV. With the exception of aquagenic pruritus, no symptoms distinguish PV from other causes of erythrocytosis

Question 19

Spurious erythrocytosis is also termed as ?

A	Budd-Chiari syndrome
B	Bartter’s syndrome
C	Gray-platelet syndrome
D	Geisbock’s syndrome

Question 20

Which of the following causes microcytic erythrocytosis ?

A	-thalassemia trait
B	Hypoxic erythrocytosis
C	Polycythemia vera (PV)
D	All of the above

Question 20 Explanation:

Only three situations cause microcytic erythrocytosis: -thalassemia trait, hypoxic erythrocytosis, and PV.

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See all quizzes of the Acute and Chronic Myeloid Leukemia at here:

Acute and Chronic Myeloid Leukemia Part 1 | Acute and Chronic Myeloid Leukemia Part 2 | Acute and Chronic Myeloid Leukemia Part 3

II. Preview all questions below

1.Which of the following is a characteristic feature of myeloproliferative disorders (MPDs) ?
A. Marrow hypercellularity
B. Thrombosis & hemorrhage
C. Risk of leukemic transformation in long term
D. All of the above

2. Which of the following is a Philadelphia (Ph) negative myeloproliferative disorder ?
A. Polycythemia vera
B. Essential thrombocythemia
C. Idiopathic myelofibrosis
D. All of the above

3. Which of the following conditions can transform into each other ?
A. Polycythemia vera (PV)
B. Primary myelofibrosis (PMF)
C. Essential thrombocytosis (ET)
D. All of the above

4. Which of the following conditions can transform into each other ?
A. Chronic myelogenous leukemia (CML)
B. Chronic neutrophilic leukemia (CNL)
C. Chronic eosinophilic leukemia (CEL)
D. None of the above

5. Which of the following about polycythemia vera is false ?
A. Clonal disorder
B. Increased phenotypically normal RBC, WBC & platelets
C. Absence of recognizable physiologic stimulus
D. None of the above
6. Which of the following illustrates the mutation in JAK2 in the pathogenesis of PV ?
A. F617V
B. F716V

C. V617F
D. V716F

7. Which out of the following do not use the JAK-STAT pathway as their essential mode of signaling ?
A. Erythropoietin
B. Interleukins 1
C. Thrombopoietin
D. Growth hormone

8. Which of the following is a member of Janus kinases ( JAKs) ?
A. Tyrosine kinase 2 (TYK2)
B. JAK1
C. JAK2
D. All of the above

9. Which of the following about signal transducer and activator of transcription (STAT) is false ?
A. DNA-binding proteins
B. Translocate to the nucleus
C. Regulate gene expression
D. None of the above

10. JAK3 associates with which of the following cytokine receptors ?
A. Interleukin-1R chain
B. Interleukin-2R chain
C. Interleukin-3R chain
D. Interleukin-4R chain

11. JAK2 mutations are associated with which of the following ?
A. Polycythemia vera
B. Essential thrombocythemia
C. Primary myelofibrosis

D. All of the above

12. Loss-of-function mutations of STAT3 result in ?
A. Susceptibility to mycobacteria
B. Chronic mucocutaneous candidiasis
C. Hyper-IgE syndrome or Job’s syndrome
D. All of the above

13. Polymorphisms of STAT3 are associated with which of the following ?
A. Ankylosing spondylitis
B. Rheumatoid arthritis
C. Systemic lupus erythematosus
D. Allergic disease

14. Which of the following is a JAK inhibitor ?
A. Ruxolitinib
B. Baricitinib
C. Tofacitinib
D. All of the above

15. JAK2 gene is located on the ?
A. Short arm of chromosome 9
B. Long arm of chromosome 9
C. Short arm of chromosome 10
D. Long arm of chromosome 10

16. Which of the following is false about Janus kinase 2 (JAK2) ?
A. Nuclear tyrosine kinase
B. Intracellular signaling by receptors for erythropoietin
C. Intracellular signaling by receptors for GM-CSF
D. Intracellular signaling by receptors for thrombopoietin

17. Which of the following is false in the pathogenesis of PV ?
A. Erythropoietin-independent erythroid colony formation
B. Hypersensitivity of PV erythroid progenitor cells to EPO
C. Resistance of PV erythroid progenitor cells to apoptosis
D. None of the above

18. Which of the following typically distinguishes polycythemia vera from other causes of erythrocytosis ?
A. Massive splenomegaly
B. High hemoglobin
C. High hematocrit
D. Aquagenic pruritus

19. Spurious erythrocytosis is also termed as ?
A. Budd-Chiari syndrome
B. Bartter’s syndrome
C. Gray-platelet syndrome
D. Geisbock’s syndrome
20. Which of the following causes microcytic erythrocytosis ?
A. -thalassemia trait
B. Hypoxic erythrocytosis
C. Polycythemia vera (PV)
D. All of the above

[MCQs] Acute and Chronic Myeloid Leukemia – Part 1

I. Start the exam by click the “Start” button

Acute and Chronic Myeloid Leukemia- Part 1

II. Preview all questions below

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