Molecular Genetics and Cellular Morphology Quizzes

The smallest organized unit of living tissue is the

nucleus

cell

organelle

cytoplasm

The cell membrane’s major components are

carbohydrates and proteins

proteins and lipids

lipids and glycoproteins

polysaccharides and lipids

Which of the following is a characteristic of osmosis?

Requires energy (ATP)

Movement of water molecules

An unusual cellular activity

Requires a carrier molecule

Which of the following is a characteristic of active transport?

Requires energy (ATP)

Movement of molecules up the concentration gradient

Requires a carrier molecule

All of the above

Phagocytosis is

a type of endocytosis

the engulfment of fluid molecules

the engulfment of particulate matter

Both A and C

Glycogen is a

protein

lipid

carbohydrate

hormone

A cellular inclusion that represents a common storage form of iron is

glycogen

vacuoles

Auer body

ferritin

The nucleus of the cell contains

chromatin, nucleoli, and nucleoplasm

chromatin, nucleoli, and ribosomes

DNA, RNA, and ribosomes

DNA, RNA, and mitochondria

The overall function of DNA is

protein and enzyme production

control of cellular function and transmission of genetic information

control of heterochromatin and euchromatin synthesis

production of cellular energy and transmission of genetic information

Heterochromatin is

genetically inactive

found in patches or clumps

genetically inactive and pale staining

Both A and B

Chromosomal translocation is

a frequent activity of homologous chromosomes in meiosis

a rearrangement of genetic material

the process in which a segment of one chromosome breaks away from its normal location

All of the above

A chromosomal deletion is

loss of a pair of chromosomes

loss of a segment of chromosome

attachment of a piece of a chromosome

an exchange of genetic material

In meiosis, the cells produced contain

a 2n number of chromosomes

22 pairs of chromosomes

23 pairs of chromosomes

23 chromosomes

Hematologists are interested in inherited disorders. Which of the following are inherited disorders?

Sickle cell trait

Sickle cell anemia

Hemophilia

All of the above

Molecular techniques are being used to detect abnormalities of

erythrocytes

leukocytes

some coagulation factors

All of the above

The first inherited hematologic disorder to be diagnosed using molecular biologic assay was

hemophilia A

factor V Leiden

sickle cell anemia

CML

PCR testing is useful in

forensic testing

genetic testing

disease diagnosis

All of the above

The traditional PCR technique

extends the length of the genomic DNA

alters the original DNA nucleotide sequence

amplifi es low levels of specifi c DNA sequences

amplifi es the target region of RNA

PCR protocol

doubles the specifi c amount of DNA with each cycle

typically has three temperature steps

repeats the number of cycles about 30

all of the above

Variations of PCR include

nested primers

real-time PCR

microarray analysis

both A and B

The method considered to be the “gold standard” of molecular methods is

DNA sequencing

Southern blot

Northern blot

Dot blot

The Southern blot procedure has diagnostic applications for diseases or disorders associated with

signifi cant changes in DNA (e.g., deletion)

determination of clonality in lymphomas of T- or B-cell origin

detection of restriction fragment length polymorphisms

all of the above

The Northern blot procedure can be used

to mass-produce erythropoietin

for analysis of the proximal product of gene expression

for antenatal genetic counseling

all of the above

All of the following are true of FISH except _____

The acronym stands for fl uorescent in situ hybridization.

It is a tissue-based molecular diagnostic assay.

It is a prenatal diagnosis of a genetic disorder.

It is useful in the diagnosis of various anemias.

Microarrays are

DNA probes bonded on glass chips

tissue-based probes

used to identify single-base mutations

used to determine clonality in lymphomas

Molecular techniques provide a diagnostic tool to

detect MRD in hematological malignancies

monitor patients following bone marrow transplantation

detect an early relapse in a patient treated for a hematological malignancy

all of the above

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Molecular Genetics and Cellular Morphology Quizzes

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The smallest organized unit of living tissue is the

The cell membrane’s major components are

Which of the following is a characteristic of osmosis?

Which of the following is a characteristic of active transport?

Phagocytosis is

Glycogen is a

A cellular inclusion that represents a common storage form of iron is

The nucleus of the cell contains

The overall function of DNA is

Heterochromatin is

Chromosomal translocation is

A chromosomal deletion is

In meiosis, the cells produced contain

Hematologists are interested in inherited disorders. Which of the following are inherited disorders?

Molecular techniques are being used to detect abnormalities of

The first inherited hematologic disorder to be diagnosed using molecular biologic assay was

PCR testing is useful in

The traditional PCR technique

PCR protocol

Variations of PCR include

The method considered to be the “gold standard” of molecular methods is

The Southern blot procedure has diagnostic applications for diseases or disorders associated with

The Northern blot procedure can be used

All of the following are true of FISH except _____

Microarrays are

Molecular techniques provide a diagnostic tool to

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