Iron Deficiency Anemia and Anemia of Chronic Inflammation

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The etiology of IDA is

nutritional deficiency

faulty iron absorption

excessive loss of iron

all of the above

Iron defi ciency is still common in

toddlers

adolescent girls

women of childbearing age

all of the above

_____ Decreased iron intake

Sprue

Colon cancer

Adolescent growth spurt

Menstruation

Meat-poor diet

_____ Faulty iron absorption

Sprue

Colon cancer

Adolescent growth spurt

Menstruation

Meat-poor diet

_____ Pathological iron loss

A. Sprue

B. Colon cancer

C. Adolescent growth spurt

D. Menstruation

E. Meat-poor diet

_____ Physiological iron loss

Sprue

Colon cancer

Adolescent growth spurt

Menstruation

Meat-poor diet

_____ Increased iron utilization

Sprue

Colon cancer

Adolescent growth spurt

Menstruation

Meat-poor diet

The average adult has _____ g of total iron.

0.2 to 1.4

1.5 to 3.4

3.5 to 5.0

5.1 to 10.0

Most functional iron in humans is found in

the bone marrow

the liver

hemoglobin molecules of erythrocytes (RBCs)

the free hemoglobin in the circulation

Most ingested iron is readily absorbed into the body in the

stomach and duodenum

duodenum and upper jejunum

ileum and duodenum

upper jejunum and ileum

Transferrin represents a

storage form of iron

beta globulin that moves iron

glycoprotein that moves iron

both B and C

In IDA, the erythrocytic indices are typically

MCV increased, MCH decreased, and MCHC decreased

MCV decreased, MCH decreased, and MCHC decreased

MCV decreased, MCH increased, and MCHC decreased

MCV decreased, MCH decreased, and MCHC normal

The peripheral blood smear demonstrates _____ red blood cells in IDA.

microcytic, hypochromic

macrocytic, hypochromic

macrocytic and spherocytic

either A or B

In IDA, the

serum iron is severely decreased and the TIBC is increased

serum iron is decreased and the TIBC is normal

serum iron is normal and the TIBC is normal

serum iron is increased and the TIBC is normal

Anemias of infl ammation/chronic diseases can be caused by

inflammation

infection

malignancy

all of the above

AOI can result from

inappropriately decreased erythropoietin

suppression of erythropoiesis by cytokines from activated macrophages and lymphocytes

impaired iron metabolism

all of the above

The typical peripheral blood fi lm of a patient with AOI typically reveals _____ erythrocytes.

microcytic, hypochromic

macrocytic, hypochromic

normocytic, normochromic

many spherocytes

Leukoerythroblastosis can appear as _____ on a peripheral blood smear.

immature leukocytes

immature erythrocytes

immature thrombocytes

both A and B

What is the most appropriate treatment for AOI?

A. Red blood cell transfusion

B. Iron therapy

C. Erythropoietin injections

D. Treatment of the inflammatory condition

Sideroblastic anemia can be caused by

A. congenital (chromosomal) defect

B. drugs (e.g., chloramphenicol)

C. association with malignant disorders (e.g., acute myelogenous leukemia)

D. all of the above

A common feature of sideroblastic anemia is

A. ringed sideroblasts

B. decreased serum iron

C. decreased serum ferritin

D. macrocytic red blood cells

The greatest portion of operational body iron is normally contained in what compound?

A. Hemoglobin

B. Ferritin

C. Cytochromes

D. Myoglobin

Storage iron in the human body is

A. found in hepatocytes

B. found in macrophages

C. sequestered as ferritin

D. all of the above

The most sensitive assay for the diagnosis of hereditary hemochromatosis (HH) is

A. serum iron

B. serum iron–binding capacity

C. transferrin

D. transferrin saturation

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Iron Deficiency Anemia and Anemia of Chronic Inflammation

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The etiology of IDA is

Iron defi ciency is still common in

_____ Decreased iron intake

_____ Faulty iron absorption

_____ Pathological iron loss

_____ Physiological iron loss

_____ Increased iron utilization

The average adult has _____ g of total iron.

Most functional iron in humans is found in

Most ingested iron is readily absorbed into the body in the

Transferrin represents a

In IDA, the erythrocytic indices are typically

The peripheral blood smear demonstrates _____ red blood cells in IDA.

In IDA, the

Anemias of infl ammation/chronic diseases can be caused by

AOI can result from

The typical peripheral blood fi lm of a patient with AOI typically reveals _____ erythrocytes.

Leukoerythroblastosis can appear as _____ on a peripheral blood smear.

What is the most appropriate treatment for AOI?

Sideroblastic anemia can be caused by

A common feature of sideroblastic anemia is

The greatest portion of operational body iron is normally contained in what compound?

Storage iron in the human body is

The most sensitive assay for the diagnosis of hereditary hemochromatosis (HH) is

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