[Immunology] Complement System Quizzes (16 tests)

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The classical complement pathway is activated by

most viruses.

antigen–antibody complexes.

fungal cell walls.

All of the above

All of the following are characteristic of complement components except

normally present in serum.

mainly synthesized in the liver.

present as active enzymes.

heat-labile.

All of the following are true of the recognition unit except

it consists of C1q, C1r, and C1s.

the subunits require calcium for binding together.

binding occurs at the FC region of antibody molecules.

Clq becomes an active esterase.

Which is referred to as C3 convertase?

C4b2a

C3bBb

iC3Bb

All of the above

Mannose-binding protein in the lectin pathway is most similar to which classical pathway component?

C1rs

C1q

Which of the following describes the role of properdin in the alternative pathway?

Stabilization of C3/C5 convertase

Conversion of B to Bb

Inhibition of C3 convertase formation

Binding to the initiating antigen

Which best characterizes the membrane attack complex?

Each pathway utilizes different factors to form it.

C5 through C9 are not added in any particular order

One MAC unit is sufficient to lyse any type of cell.

C9 polymerizes to form the transmembrane channel.

All of the following represent functions of the complement system except

decreased clearance of antigen–antibody complexes.

lysis of foreign cells.

increase in vascular permeability.

migration of neutrophils to the tissues.

Which of the following is true of the amplification loop in complement activation?

It is found in the alternative pathway.

iC3 binds factor B to generate amplification.

C3b is the product that is increased.

All of the above

Factor H acts by competing with which of the following for the same binding site?

Factor B

Factor D

C3B

Factor I

A lack of CR1 receptors on red blood cells would result in which of the following?

Decreased binding of C3b to red blood cells

Lack of clearance of immune complexes by the spleen

Increased breakdown of C3b to C3d and C3dg

All of the above

A lack of CR2 on cell membranes would result in which of the following?

Decrease in hemolysis

Increased susceptibility to infection

Decreased antibody production

Increase in antibody of the IgG class

Why is complement not activated with anti-Rh (D) antibodies?

Rh antigens stimulate little antibody production.

Rh antigens are too far apart on red blood cells.

Rh antibodies are not capable of fixing complement.

DAF protects red blood cells from buildup of antibody.

The CH50 test measures which of the following?

The dilution of patient serum required to lyse 50 percent of a standard concentration of sensitized sheep red blood cells

Functioning of both the classical and alternative pathways

Genetic deficiencies of any of the complement components

All of the above

Which of the following would be most effective in preventing bystander lysis of red blood cells?

C1INH

Factor B

DAF

Factor H

Decreased CH50 levels may be caused by

inadequate refrigeration of specimen.

coagulation-associated complement consumption.

autoimmune disease process.

All of the above

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[Immunology] Complement System Quizzes (16 tests)

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The classical complement pathway is activated by

All of the following are characteristic of complement components except

All of the following are true of the recognition unit except

Which is referred to as C3 convertase?

Mannose-binding protein in the lectin pathway is most similar to which classical pathway component?

Which of the following describes the role of properdin in the alternative pathway?

Which best characterizes the membrane attack complex?

All of the following represent functions of the complement system except

Which of the following is true of the amplification loop in complement activation?

Factor H acts by competing with which of the following for the same binding site?

A lack of CR1 receptors on red blood cells would result in which of the following?

A lack of CR2 on cell membranes would result in which of the following?

Why is complement not activated with anti-Rh (D) antibodies?

The CH50 test measures which of the following?

Which of the following would be most effective in preventing bystander lysis of red blood cells?

Decreased CH50 levels may be caused by

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