Hemolytic Anemias

1. Hemolytic disruption of the erythrocyte involves

A. an alteration in the erythrocyte membrane

B. a defect of the hemoglobin molecule

C. an antibody coating the erythrocyte

D. physical trauma

Correct! Wrong!

2. _____ Intravascular hemolysis

A. Destruction of RBCs outside the circulatory blood

B. Destruction of RBCs within the circulatory blood

Correct! Wrong!

3. _____ Extravascular hemolysis

A. Destruction of RBCs outside the circulatory blood

B. Destruction of RBCs within the circulatory blood

Correct! Wrong!

4. Which of the following tests is not useful in determining increased erythrocyte destruction?

A. Reticulocyte count

B. Total leukocyte count

C. Serum haptoglobin

D. Unconjugated bilirubin

Correct! Wrong!

5. _____ G6PD deficiency

A. Structural membrane defect

B. Erythrocytic enzyme defect

C. Defect of the hemoglobin molecule

Correct! Wrong!

6. _____ Hereditary spherocytosis

A. Structural membrane defect

B. Erythrocytic enzyme defect

C. Defect of the hemoglobin molecule

Correct! Wrong!

7. _____ Thalassemia

A. Structural membrane defect

B. Erythrocytic enzyme defect

C. Defect of the hemoglobin molecule

Correct! Wrong!

8. _____ Pyruvate kinase (PK) deficiency

A. Structural membrane defect

B. Erythrocytic enzyme defect

C. Defect of the hemoglobin molecule

Correct! Wrong!

9. _____ Hereditary spherocytosis

A. An overabundance of oval-shaped red cells

B. A permeability disorder

C. The most common prevalent hereditary hemolytic anemia among people of Northern European descent

D. Can be seen in the genetic hemoglobin defect, thalassemia

E. A subgroup of common hereditary elliptocytosis

Correct! Wrong!

10. _____ Hereditary elliptocytosis

A. An overabundance of oval-shaped red cells

B. A permeability disorder

C. The most common prevalent hereditary hemolytic anemia among people of Northern European descent

D. Can be seen in the genetic hemoglobin defect, thalassemia

E. A subgroup of common hereditary elliptocytosis

Correct! Wrong!

11. _____ Hereditary pyropoikilocytosis (HPP)

A. An overabundance of oval-shaped red cells

B. A permeability disorder

C. The most common prevalent hereditary hemolytic anemia among people of Northern European descent

D. Can be seen in the genetic hemoglobin defect, thalassemia

E. A subgroup of common hereditary elliptocytosis

Correct! Wrong!

12. _____ Hereditary stomatocytosis

A. An overabundance of oval-shaped red cells

B. A permeability disorder

C. The most common prevalent hereditary hemolytic anemia among people of Northern European descent

D. Can be seen in the genetic hemoglobin defect, thalassemia

E. A subgroup of common hereditary elliptocytosis

Correct! Wrong!

13. _____ Hereditary xerocytosis

A. An overabundance of oval-shaped red cells

B. A permeability disorder

C. The most common prevalent hereditary hemolytic anemia among people of Northern European descent

D. Can be seen in the genetic hemoglobin defect, thalassemia

E. A subgroup of common hereditary elliptocytosis

Correct! Wrong!

14. Heinz bodies are associated with the congenital hemolytic anemia

A. G6PD deficiency

B. abetalipoproteinemia

C. hereditary spherocytosis

D. hemolytic anemias

Correct! Wrong!

15. A hemolytic crisis may be precipitated in 10% of American black males suffering from G6PD deficiency by

A. fava beans

B. primaquine

C. quinine

D. quinidine

Correct! Wrong!

What is the most common glycolytic enzyme deficiency associated with the aerobic pathway of erythrocyte metabolism?

A. Glucose-6-phosphate dehydrogenase (G6PD)

B. Pyruvate kinase (PK)

C. Methemoglobin reductase deficiency

D. Hexokinase deficiency

Correct! Wrong!

17. What is the most common glycolytic enzyme deficiency associated with the anaerobic pathway of erythrocyte metabolism?

A. Glucose-6-phosphate dehydrogenase (G6PD)

B. Pyruvate kinase (PK)

C. Methemoglobin reductase deficiency

D. Hexokinase deficiency

Correct! Wrong!

18. What laboratory assay would specifi cally indicate a deficiency of G6PD enzyme?

A. Heinz bodies on peripheral blood smears

B. Reticulocyte count

C. Hemoglobin and hematocrit

D. Osmotic fragility test

Correct! Wrong!

19. What enzyme defi ciency causes methemoglobinemia?

A. Glucose-6-phosphate dehydrogenase (G6PD)

B. Pyruvate kinase (PK)

C. NADH-methemoglobin reductase

D. Hexokinase deficiency

Correct! Wrong!

20. Acquired hemolytic anemia can be caused by

A. chemicals or drugs

B. infectious organisms

C. antibody reactions

D. all of the above

Correct! Wrong!

21. The infectious microorganism directly associated with hemolytic uremic syndrome is

A. Pasteurella tularensis

B. E. coli O157-H7

C. Staphylococcus aureus

D. Clostridia botulinum

Correct! Wrong!

22. _____ Warm-type autoimmune hemolytic anemia (AIHA)

A. IgM, usually anti-I

B. Rh antibodies are the most frequent cause

C. Usually occurs in newborn infants

Correct! Wrong!

23. _____ Cold-type AIHA

A. IgM, usually anti-I

B. Rh antibodies are the most frequent cause

C. Usually occurs in newborn infants

Correct! Wrong!

24. _____ Isoimmune hemolytic anemia

A. IgM, usually anti-I

B. Rh antibodies are the most frequent cause

C. Usually occurs in newborn infants

Correct! Wrong!

25. The erythrocyte alteration characteristically associated with hemolytic anemias is

A. hypochromia

B. macrocytosis

C. spherocytosis

D. burr cells

Correct! Wrong!

26. What laboratory procedures would refl ect a typical hemolytic anemia?

A. Increased osmotic fragility

B. Increased total serum bilirubin

C. Increased reticulocyte count, unless hematopoiesis is suppressed

D. All of the above

Correct! Wrong!

27. Which of the following is not associated with hemolytic anemia?

A. Decreased hemoglobin and packed cell volume

B. Increased reticulocyte count

C. Increased serum haptoglobins

D. Decreased erythrocyte survival

Correct! Wrong!

28. Paroxysmal nocturnal hemoglobinuria exhibits sensitivity of one population of red blood cells to

A. warm antibodies

B. cold antibodies

C. complement

D. either A or B

Correct! Wrong!

29. Paroxysmal nocturnal hemoglobinuriaepisodes are usually associated with

A. cold temperatures

B. hot temperatures

C. sleep

D. certain foods or drugs

Correct! Wrong!

30. The defect in PNH probably is a (an) _____ associated defect of the red cell membrane.

A. structural protein

B. hemoglobin

C. antibody

D. enzyme

Correct! Wrong!

Hemolytic Anemias

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1. Hemolytic disruption of the erythrocyte involves

2. _____ Intravascular hemolysis

3. _____ Extravascular hemolysis

4. Which of the following tests is not useful in determining increased erythrocyte destruction?

5. _____ G6PD deficiency

6. _____ Hereditary spherocytosis

7. _____ Thalassemia

8. _____ Pyruvate kinase (PK) deficiency

9. _____ Hereditary spherocytosis

10. _____ Hereditary elliptocytosis

11. _____ Hereditary pyropoikilocytosis (HPP)

12. _____ Hereditary stomatocytosis

13. _____ Hereditary xerocytosis

14. Heinz bodies are associated with the congenital hemolytic anemia

15. A hemolytic crisis may be precipitated in 10% of American black males suffering from G6PD deficiency by

What is the most common glycolytic enzyme deficiency associated with the aerobic pathway of erythrocyte metabolism?

17. What is the most common glycolytic enzyme deficiency associated with the anaerobic pathway of erythrocyte metabolism?

18. What laboratory assay would specifi cally indicate a deficiency of G6PD enzyme?

19. What enzyme defi ciency causes methemoglobinemia?

20. Acquired hemolytic anemia can be caused by

21. The infectious microorganism directly associated with hemolytic uremic syndrome is

22. _____ Warm-type autoimmune hemolytic anemia (AIHA)

23. _____ Cold-type AIHA

24. _____ Isoimmune hemolytic anemia

25. The erythrocyte alteration characteristically associated with hemolytic anemias is

26. What laboratory procedures would refl ect a typical hemolytic anemia?

27. Which of the following is not associated with hemolytic anemia?

28. Paroxysmal nocturnal hemoglobinuria exhibits sensitivity of one population of red blood cells to

29. Paroxysmal nocturnal hemoglobinuriaepisodes are usually associated with

30. The defect in PNH probably is a (an) _____ associated defect of the red cell membrane.

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1. Hemolytic disruption of the erythrocyte involves

2. _____ Intravascular hemolysis

3. _____ Extravascular hemolysis

4. Which of the following tests is not useful in determining increased erythrocyte destruction?

5. _____ G6PD deficiency

6. _____ Hereditary spherocytosis

7. _____ Thalassemia

8. _____ Pyruvate kinase (PK) deficiency

9. _____ Hereditary spherocytosis

10. _____ Hereditary elliptocytosis

11. _____ Hereditary pyropoikilocytosis (HPP)

12. _____ Hereditary stomatocytosis

13. _____ Hereditary xerocytosis

14. Heinz bodies are associated with the congenital hemolytic anemia

15. A hemolytic crisis may be precipitated in 10% of American black males suffering from G6PD deficiency by

What is the most common glycolytic enzyme deficiency associated with the aerobic pathway of erythrocyte metabolism?

17. What is the most common glycolytic enzyme deficiency associated with the anaerobic pathway of erythrocyte metabolism?

18. What laboratory assay would specifi cally indicate a deficiency of G6PD enzyme?

19. What enzyme defi ciency causes methemoglobinemia?

20. Acquired hemolytic anemia can be caused by

21. The infectious microorganism directly associated with hemolytic uremic syndrome is

22. _____ Warm-type autoimmune hemolytic anemia (AIHA)

23. _____ Cold-type AIHA

24. _____ Isoimmune hemolytic anemia

25. The erythrocyte alteration characteristically associated with hemolytic anemias is

26. What laboratory procedures would refl ect a typical hemolytic anemia?

27. Which of the following is not associated with hemolytic anemia?

28. Paroxysmal nocturnal hemoglobinuria exhibits sensitivity of one population of red blood cells to

29. Paroxysmal nocturnal hemoglobinuriaepisodes are usually associated with

30. The defect in PNH probably is a (an) _____ associated defect of the red cell membrane.

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