[MCQs] Coagulation Disorders - Part 1

I. Start the exam by click the “Start” button

Coagulation Disorders- Part 1

Please wait while the activity loads.
If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled.

If loading fails, click here to try again

Start

Congratulations - you have completed Coagulation Disorders- Part 1. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

Your answers are highlighted below.

Question 1

Factor X or Stuart-Prower factor is named after ?

A	Patients - Ms. Audrey Prower & Mr. Rufus Stuart
B	Doctors - Ms. Audrey Prower & Mr. Rufus Stuart
C	Scientists - Ms. Audrey Prower & Mr. Rufus Stuart
D	Politicians - Ms. Audrey Prower & Mr. Rufus Stuart

Question 1 Explanation:

Factor X, or Stuart-Prower factor was identified in Ms. Audrey Prower of London, who had lifelong bleeding tendency. An American group identified the same factor in Mr. Rufus Stuart (1957)

Question 2

Coagulation-related protein prekallikrein is also called ?

A	Fletcher Factor
B	Fitzgerald Factor
C	MacFarlane Factor
D	Furie Facto

Question 2 Explanation:

Furie Facto

Question 3

Factor IX or Christmas Factor is named after ?

A	Patient - Stephen Christmas
B	Doctor - Stephen Christmas
C	Scientist - Stephen Christmas
D	Politician - Stephen Christmas

Question 3 Explanation:

Stephen Christmas (1947-1993) of Canada sufferd from hemophilia B. He died due to transfusionrelated AIDS

Question 4

Prolonged activated partial thromboplastin time indicates ?

A	FII deficiency
B	FV deficiency
C	FVIII deficiency
D	FX deficiency

Question 5

Prolongation of both PT & aPTT suggests deficiency of ?

A	FV
B	FX
C	FII
D	All of the above

Question 6

Which of the following is an example of acquired deficiencies of plasma coagulation ?

A	Hemorrhagic diathesis of liver disease
B	Disseminated intravascular coagulation (DIC)
C	Vitamin K deficiency
D	All of the above

Question 6 Explanation:

Acquired deficiencies of plasma coagulation factors are more frequent than congenital disorders. Most common disorders include hemorrhagic diathesis of liver disease, disseminated intravascular coagulation (DIC), and vitamin K deficiency. Blood coagulation is hampered by the deficiency of more than one clotting factor

Question 7

Which of the following could lead to a prolonged aPTT and normal PT ?

A	Deficiency of factor VIII, IX, or XI
B	Von Willebrand’s disease
C	Unfractionated heparin
D	All of the above

Question 7 Explanation:

Deficiency of factor VIII, IX, or XI, Inhibitor of factor VIII, IX, or XI, Von Willebrand’s disease, Unfractionated heparin and Direct thrombin inhibitors cause a prolonged aPTT and normal PT

Question 8

Which of the following could lead to a prolonged PT and normal aPTT ?

A	Deficiency of factor VII
B	Vitamin K deficiency
C	Warfarin therapy
D	All of the above

Question 9

Which of the following could lead to a prolonged aPTT and prolonged PT ?

A	Deficiency of prothrombin, fibrinogen, factor V or X
B	Supratherapeutic doses of heparin or warfarin
C	Disseminated intravascular coagulation
D	All of the above

Question 9 Explanation:

Deficiency of prothrombin, fibrinogen, factor V, or factor X, Inhibitor of prothrombin, fibrinogen, factor V, or factor X, Supratherapeutic doses of heparin or warfarin, Liver disease, Disseminated intravascular coagulation and Argatroban could lead to a prolonged aPTT and prolonged PT

Question 10

Which of the following is a disorder of primary hemostasis ?

A	Thrombocytopenia
B	Qualitative platelet disorders
C	von Willebrand’s disease
D	All of the above

Question 11

Which of the following royal persons was a clinically normal carrier of hemophilia ?

A	Queen Marie
B	Queen Elizabeth I
C	Queen Victoria
D	Queen Harper

Question 11 Explanation:

Queen Victoria, a clinically normal carrier of hemophilia, had one son, Leopold, who had hemophilia and two daughters, Alice and Beatrice, who were carriers and who, in turn, transmitted the disease to the Russian, Prussian, and Spanish royal families

Question 12

World Hemophilia Day is observed on ?

A	April 17
B	May 17
C	June 17
D	July 17

Question 13

What is the prevalence of hemophilia ?

A	1 in 10,000 males worldwide
B	1 in 100.000 males worldwide
C	1 in 10,00000 males worldwide
D	1 in 10,000000 males worldwide

Question 13 Explanation:

Hemophilia is an X-linked recessive hemorrhagic disease due to mutations in the F8 gene (hemophilia A or classic hemophilia) or F9 gene (hemophilia B). The disease affects 1 in 10,000 males worldwide, in all ethnic groups.

Question 14

Most common hemophilia A F8 mutations results from ?

A	Inversion of intron 22 DNA sequence
B	nversion of intron 23 DNA sequence
C	Inversion of intron 24 DNA sequence
D	Inversion of intron 25 DNA sequence

Question 14 Explanation:

40 to 50 percent of the mutations causing severe hemophilia A are due to an inversion of DNA sequences in intron 22 that disruptes factor VIII gene.

Question 15

Family history of hemophilia is absent in what percentage of cases of hemophilia ?

A	~10 %
B	~20 %
C	~30 %
D	~40 %

Question 15 Explanation:

~40 %

Question 16

The minimal level of most clotting factors needed for adequate hemostasis is ?

A	5 %
B	10 %
C	15 %
D	25 %

Question 16 Explanation:

Those with residual FVIII or FIX activity >25% of normal, hemophilia is discovered only by bleeding after major trauma or during presurgery laboratory tests.

Question 17

Clinically, hemophilia is classified as severe when residual activity of FVIII is ?

A	< 1%
B	< 2%
C	< 3%
D	< 4%

Question 17 Explanation:

When residual activity of FVIII or FIX is < 1%, hemophilia is classified as severe. Between 1 - 5%, it is moderate. Between 6 - 30%, it is mild

Question 18

One unit of factor VIII is defined as the amount of factor VIII present in ?

A	1 mL normal plasma
B	10 mL normal plasma
C	100 mL normal plasma
D	1000 mL normal plasma

Question 18 Explanation:

One unit is by definition the amount of FVIII (100 ng/mL) or FIX (5 g/mL) in 1 mL of normal plasma. One unit of FVIII per kilogram of body weight increases the plasma FVIII level by 2%.

Question 19

Factor VIII has a half-life of ?

A	1 to 4 hours
B	4 to 8 hours
C	8 to 12 hours
D	12 to 16 hours

Question 19 Explanation:

FVIII half-life of 8 to 12 hours, therefore requires twice a day administration to maintain therapeutic levels. Half-life of FIX is about 24 hours

Question 20

Which of the following is false about antihemophilic factor (AHF) ?

A	Multiple-chain protein
B	Synthesized in liver
C	Synthesized in liver
D	None of the above

Question 21

Which of the following is false about antihemophilic factor (AHF) ?

A	Regulates activation of factor X
B	Gene for factor VIII is on the X chromosome
C	Symptomatic patients have factor VIII levels of < 5 %
D	None of the above

Question 22

Which of the following is false about hemophilia A ?

A	Severe iron-deficiency anemia is uncommon
B	Severe iron-deficiency anemia is uncommon
C	Prenatal diagnosis from chorionic villus biopsy or amniocentesis possible
D	None of the above

Question 23

Which of the following medicines is useful in managing bleeding in hemophilia patients ?

A	Desmopressin (DDAVP)
B	 aminocaproic acid (EACA)
C	Tranexamic acid
D	All of the above

Question 23 Explanation:

DDAVP is a synthetic vasopressin analogue that causes a transient rise in FVIII and vWF, but not FIX, in patients with mild to moderate hemophilia A but not in in severe hemophilia A as there are no stores to release. Repeated dosing of DDAVP results in tachyphylaxis. Oral antifibrinolytic drugs such as e-aminocaproic acid (EACA) or tranexamic acid enhance local hemostasis.

Question 24

Laboratory test required to confirm presence of an inhibitor alloantibodies to FVIII is ?

A	PT mixed with normal plasma
B	PT mixed with patients plasma
C	aPTT mixed with normal plasma
D	aPTT mixed with patients plasma

Question 24 Explanation:

Laboratory test for confirming presence of an inhibitor is aPTT mixed with normal plasma. In hemophilia, a 1:1 mix with normal plasma corrects aPTT. In inhibitor patients, aPTT on a 1:1 mix is abnormally prolonged, as inhibitor neutralizes FVIII clotting activity of normal plasma

Question 25

Alloantibody inhibitor formation to FVIII occurs after how many cumulative days of exposure ?

A	10
B	20
C	30
D	40

Question 25 Explanation:

Formation of alloantibodies to FVIII or FIX is a major complication of hemophilia treatment with a prevalence of 5-10%. Inhibitors appear early in life & after 10 cumulative days of exposure.

Question 26

Which of the following assay is used to define the specificity of the inhibitor and its titer ?

A	Minnesota assay
B	Bethesda assay
C	Glasgow assay
D	Athens assay

Question 26 Explanation:

Bethesda assay defines the specificity of the inhibitor and its titer. One Bethesda unit (BU) is the amount of antibody that neutralizes 50% of FVIII or FIX present in normal plasma after 2 hours of incubation at 37°C

Once you are finished, click the button below. Any items you have not completed will be marked incorrect. Get Results

There are 26 questions to complete.

←

List

→

Return

Shaded items are complete.

1	2	3	4	5
6	7	8	9	10
11	12	13	14	15
16	17	18	19	20
21	22	23	24	25
26	End

Return

See all quizzes of the Coagulation Disorders at here:

Coagulation Disorders – Part 1 | Coagulation Disorders – Part 2

II. Preview all questions below:

1. Factor X or Stuart-Prower factor is named after ?
A. Patients – Ms. Audrey Prower & Mr. Rufus Stuart
B. Doctors – Ms. Audrey Prower & Mr. Rufus Stuart
C. Scientists – Ms. Audrey Prower & Mr. Rufus Stuart
D. Politicians – Ms. Audrey Prower & Mr. Rufus Stuart

2. Coagulation-related protein prekallikrein is also called ?
A. Fletcher Factor
B. Fitzgerald Factor
C. MacFarlane Factor
D. Furie Factor

3. Factor IX or Christmas Factor is named after ?
A. Patient – Stephen Christmas
B. Doctor – Stephen Christmas
C. Scientist – Stephen Christmas
D. Politician – Stephen Christmas

4. An isolated abnormal prothrombin time (PT) suggests deficiency of ?
A. FV
B. FVI

C. FVII
D. FVIII

5. Prolonged activated partial thromboplastin time indicates ?
A. FII deficiency
B. FV deficiency
C. FVIII deficiency
D. FX deficiency

6. Prolongation of both PT & aPTT suggests deficiency of ?
A. FV
B. FX
C. FII
D. All of the above

7. Which of the following is a test for blood coagulation ?
A. PT
B. aPTT
C. Thrombin time (TT)
D. All of the above

8. Which of the following is an example of acquired deficiencies of plasma coagulation ?
A. Hemorrhagic diathesis of liver disease
B. Disseminated intravascular coagulation (DIC)
C. Vitamin K deficiency
D. All of the above

9. Which of the following could lead to a prolonged aPTT and normal PT ?
N Engl J Med 2009;361:1887-94
A. Deficiency of factor VIII, IX, or XI
B. Von Willebrand’s disease
C. Unfractionated heparin
D. All of the above

10. Which of the following could lead to a prolonged PT and normal aPTT ?
A. Deficiency of factor VII
B. Vitamin K deficiency
C. Warfarin therapy
D. All of the above

11. Which of the following could lead to a prolonged aPTT and prolonged PT ?
A. Deficiency of prothrombin, fibrinogen, factor V or X
B. Supratherapeutic doses of heparin or warfarin
C. Disseminated intravascular coagulation
D. All of the above

12. Which of the following is a disorder of primary hemostasis ?
A. Thrombocytopenia
B. Qualitative platelet disorders
C. von Willebrand’s disease
D. All of the above

13. Which of the following royal persons was a clinically normal carrier of hemophilia ?
A. Queen Marie
B. Queen Elizabeth I
C. Queen Victoria
D. Queen Harper

14. World Hemophilia Day is observed on ?
A. April 17
B. May 17
C. June 17
D. July 17

15. What is the prevalence of hemophilia ?
A. 1 in 10,000 males worldwide
B. 1 in 100.000 males worldwide
C. 1 in 10,00000 males worldwide
D. 1 in 10,000000 males worldwide

16. Most common hemophilia A F8 mutations results from ?
A. Inversion of intron 22 DNA sequence
B. Inversion of intron 23 DNA sequence
C. Inversion of intron 24 DNA sequence
D. Inversion of intron 25 DNA sequence

17. Family history of hemophilia is absent in what percentage of cases of hemophilia ?
A. ~10 %
B. ~20 %
C. ~30 %
D. ~40 %

18. The minimal level of most clotting factors needed for adequate hemostasis is ?
A. 5 %
B. 10 %
C. 15 %
D. 25 %

19. Clinically, hemophilia is classified as severe when residual activity of FVIII is ?
A. < 1%
B. < 2%
C. < 3%
D. < 4%

20. One unit of factor VIII is defined as the amount of factor VIII present in ?
A. 1 mL normal plasma
B. 10 mL normal plasma
C. 100 mL normal plasma
D. 1000 mL normal plasma

21. Factor VIII has a half-life of ?
A. 1 to 4 hours
B. 4 to 8 hours
C. 8 to 12 hours
D. 12 to 16 hours

22. Which of the following is false about antihemophilic factor (AHF) ?
A. Multiple-chain protein
B. Synthesized in liver
C. Circulates complexed to vWF protein
D. None of the above

23. Which of the following is false about antihemophilic factor (AHF) ?
A. Regulates activation of factor X
B. Gene for factor VIII is on the X chromosome
C. Symptomatic patients have factor VIII levels of < 5 %
D. None of the above

24. Which of the following is false about hemophilia A ?
Harrison’s 17th Ed. 682
A. Severe iron-deficiency anemia is uncommon
B. Patients with type I inhibitor should not receive factor VIII
C. Prenatal diagnosis from chorionic villus biopsy or
amniocentesis possible
D. None of the above

25. Which of the following medicines is useful in managing bleeding in hemophilia patients ?
A. Desmopressin (DDAVP)
B.  aminocaproic acid (EACA)
C. Tranexamic acid
D. All of the above

26. Laboratory test required to confirm presence of an inhibitor alloantibodies to FVIII is ?
A. PT mixed with normal plasma
B. PT mixed with patients plasma
C. aPTT mixed with normal plasma
D. aPTT mixed with patients plasma
.
27. Alloantibody inhibitor formation to FVIII occurs after how many cumulative days of exposure ?
A. 10
B. 20
C. 30
D. 40

28. Which of the following assay is used to define the specificity of the inhibitor and its titer ?
A. Minnesota assay
B. Bethesda assay
C. Glasgow assay
D. Athens assay

[MCQs] Coagulation Disorders – Part 1

I. Start the exam by click the “Start” button

Coagulation Disorders- Part 1

II. Preview all questions below:

Share this:

Related

[MCQs] Disorders of Platelets and Vessel Wall- Part 4

[MCQs] Coagulation Disorders – Part 2

You may also like

Leave a Comment Cancel Reply