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NUCLEIC ACIDS- Part 11
See all quizzes of NUCLEIC ACIDS- Part 11 here:
1 Mammalian RNA polymerase I synthesises
(A) mRNA (B) rRNA
(C) tRNA (D) hnRNA
2. Mammalian RNA polymerase III synthesises
(A) rRNA (B) mRNA
(C) tRNA (D) hnRNA
3. In mammals, synthesis of mRNA is
catalysed by
(A) RNA polymerase I (B) RNA polymerase II
(C) RNA polymerase III(D) RNA polymerase IV
4. Heterogeneous nuclear RNA is the
precursor of
(A) mRNA (B) rRNA
(C) tRNA (D) None of these
5. Post-transcriptional modification of hnRNA
involves all of the following except
(A) Addition of 7-methylguanosine triphosphate
cap
(B) Addition of polyadenylate tail
(C) Insertion of nucleotides
(D) Deletion of introns
6. Newly synthesized tRNA undergoes posttranscriptional
modifications which include
all the following except
(A) Reduction in size
(B) Methylation of some bases
(C) Formation of pseudouridine
(D) Addition of C-C-A terminus at 5’ end
7. Post-transcriptional modification does not
occur in
(A) Eukaryotic tRNA (B) Prokaryotic tRNA
(C) Eukaryotic hnRNA (D) Prokaryotic mRNA
8. A consensus sequence on DNA, called TATA
box, is the site for attachment of
(A) RNA-dependent DNA polymerase
(B) DNA-dependent RNA polymerase
(C) DNA-dependent DNA polymerase
(D) DNA topoisomerase II
9. Polyadenylate tail is not present in mRNA
synthesising
(A) Globin (B) Histone
(C) Apoferritin (D) Growth hormone
10. Introns are present in DNA of
(A) Viruses (B) Bacteria
(C) Man (D) All of these
11. A mammalian DNA polymerase among
the following is
(A) DNA polymerase α
(B) DNA polymerase I
(C) DNA polymerase II
(D) DNA polymerase IV
12. Mammalian DNA polymerase γ is located
in
(A) Nucleus (B) Nucleolus
(C) Mitochondria (D) Cytosol
13. Replication of nuclear DNA in mammals
is catalysed by
(A) DNA polymerase α
(B) DNA polymerase β
(C) DNA polymerase γ
(D) DNA polymerase III
14. Primase activity is present in
(A) DNA polymerase II
(B) DNA polymerase α
(C) DNA polymerase β
(D) DNA polymerase δ
15. The mammalian DNA polymerase
involved in error correction is
(A) DNA polymerase α
(B) DNA polymerase β
(C) DNA polymerase γ
(D) DNA polymerase δ
16. Novobicin inhibits the synthesis of
(A) DNA (B) mRNA
(C) tRNA (D) rRNA
17. Ciprofloxacin inhibits the synthesis of
(A) DNA (B) mRNA
(C) tRNA (D) rRNA
18. Ciprofloxacin inhibits
(A) DNA topisomerase II
(B) DNA polymerase I
(C) DNA polymerase III
(D) DNA gyrase
19. Rifampicin inhibits
(A) Unwinding of DNA
(B) Initiation of replication
(C) Initiation of translation
(D) Initiation of transcription
20. Actinomycin D binds to
(A) Double stranded DNA
(B) Single stranded DNA
(C) Single stranded RNA
(D) DNA-RNA hybrid
21. DNA contains some palindromic sequences
which
(A) Mark the site for the formation of replication
forks
(B) Direct DNA polymerase to turn back to
replicate the other strand
(C) Are recognized by restriction enzymes
(D) Are found only in bacterial DNA
22. Introns in genes
(A) Encode the amino acids which are removed
during post-translational modification
(B) Encode signal sequences which are removed
before secretion of the proteins
(C) Are the non-coding sequences which are not
translated
(D) Are the sequences that intervene between
two genes
23. All of the following statements about
post-transcriptional processing of tRNA
are true except
(A) Introns of some tRNA precursors are removed
(B) CCA is added at 3′ end
(C) 7-Methylguanosine triphosphate cap is
added at 5′ end
(D) Some bases are methylated
24. α-Amanitin inhibits
(A) DNA polymerase II of prokaryotes
(B) DNA polymerase α of eukaryotes
(C) RNA polymerase II of eukaryotes
(D) RNA-dependent DNA polymerase
25. Ciprofloxacin inhibits the synthesis of
(A) DNA in prokaryotes
(B) DNA in prokaryotes and eukaryotes
(C) RNA in prokaryotes
(D) RNA in prokaryotes and eukaryotes
26. All of the following statements about
bacterial promoters are true except
(A) They are smaller than eukaryotic promoters
(B) They have two consensus sequences upstream
from the transcription star site
(C) TATA box is the site for attachment of RNA
polymerase
(D) TATA box has a high melting temperature
27. All of the following statements about
eukaryotic promoters are true except
(A) They may be located upstream or down stream
from the structural gene
(B) They have two consensus sequences
(C) One consensus sequence binds RNA
polymerase
(D) Mutations in promoter region can decrease the
efficiency of transcription of the structural gene
28. In sanger’s method of DNA sequence
determination, DNA synthesis is stopped
by using
(A) 1′, 2′- Dideoxyribonucleoside triphosphates
(B) 2′, 3′- Dideoxyribonucleoside triphosphates
(C) 2′, 4′- Dideoxyribonucleoside triphosphates
(D) 2′, 5′ – Dideoxyribonucleoside triphosphates
29. tRNA genes have
(A) Upstream promoters
(B) Downstream promoters
(C) Intragenic promoters
(D) No promoters
30. All of the following statements about
tRNA are true except
(A) It is synthesized as a large precursor
(B) It is processed in the nucelolus
(C) It has no codons or anticodons
(D) Genes for rRNA are present in single copies
