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Pheochromocytoma- Part 1
See all quizzes of Pheochromocytoma at here:
Pheochromocytoma- Part 1| Pheochromocytoma- Part 2| Pheochromocytoma- Part 3
1.In pheochromocytoma, mean age at diagnosis is about ?
A. 20 years
B. 30 years
C. 40 years
D. 50 years
2. The “rule of tens” for pheochromocytomas states ?
A. ~ 10 % are bilateral
B. ~ 10 % are extraadrenal
C. ~ 10 % are malignant
D. All of the above
3. Which of the following about paraganglioma is false ?
A. Catecholamine-producing tumors in head & neck
B. Tumors arising from parasympathetic nervous system
C. Unknown etiology
D. None of the above
4. Germ-line mutations in which of the following can cause inherited
pheochromocytoma ?
A. RET
B. VHL
C. NF1
D. All of the above
5. The VHL protein is a component of ?
A. Ubiquitin E3 ligase
B. Mitochondrial kinase
C. Cytosolic kinase
D. All of the above
6. Which of the following diseases is related to E3 ubiquitin protein
ligase ?
A. Hallervorden-Spatz disease
B. Wilson’s disease
C. Parkinson’s Disease
D. Frontotemporal dementia
7. Classic triad of pheochromocytoma consists of all except ?
A. Palpitation
B. Hypertension
C. Headache
D. Profuse sweating
8. In pheochromocytoma, which of the following is the most
common symptom ?
A. Sustained hypertension
B. Paroxysmal hypertension
C. Orthostatic hypotension
D. Flushing
9. In pheochromocytoma, which of the following is the least common
symptom ?
A. Palpitations
B. Sweating
C. Headache
D. Anxiety
10. Paroxysmal attacks in pheochromocytoma generally last for ?
A. < 1 hour
B. < 3 hour
C. < 6 hour
D. < 12 hour
11. Paroxysmal attack in pheochromocytoma is precipitated by ?
A. Positional changes
B. Exercise
C. Pregnancy
D. All of the above
12. Drugs that can induce paroxysmal attacks in pheochromocytoma
include ?
A. Opiates
B. Histamine
C. Adrenocorticotropin
D. All of the above
13. Drugs that can induce paroxysmal attacks in pheochromocytoma
include ?
A. Glucagon
B. IV Methyldopa
C. Tricyclic antidepressants
D. All of the above
14. Which of the following is secreted most by pheochromocytoma ?
A. Norepinephrine
B. Epinephrine
C. Dopamine
D. Homovanillic acid (HVA)
15. Plasma and urinary metanephrine measure which metabolite of
catecholamines ?
A. E-methylated metabolites
B. S-methylated metabolites
C. L-methylated metabolites
D. O-methylated metabolites
16. Medication that increase catecholamines is ?
A. Levodopa
B. Labetalol
C. Sympathomimetics
D. All of the above
17. Plasma test for pheochromocytoma is estimation of ?
A. Catecholamines
B. Metanephrines
C. Chromagranin A
D. All of the above
18. Urinary test for pheochromocytoma is estimation of ?
A. Urinary VMA
B. Metanephrines
C. Catecholamines
D. All of the above
19. Upper limit of normal for total urinary catecholamines is ?
A. 10 and 50 μg/day
B. 50 and 100 μg/day
C. 100 and 150 μg/day
D. 150 and 250 μg/day
20. False-positive increases in catecholamine excretion result
from ?
A. Methyldopa
B. Levodopa
C. Labetalol
D. All of the above
21. Upper limit of normal of VMA excretion per day is ?
A. 2 mg
B. 5 mg
C. 7 mg
D. 9 mg
22. Upper limit of normal of total metanephrine excretion per day
is ?
A. 0.3 mg
B. 1.3 mg
C. 2.3 mg
D. 3.3 mg
23. Which out of the following has maximum sensitivity in the
diagnosis of pheochromocytoma ?
A. Plasma-free metanephrines
B. Plasma catecholamines
C. Urinary-fractionated metanephrines
D. VMA
