[MCQ] Parkinson’s Disease (PD) and Other Movement Disorders- Part 5

I. Start the exam by click the “Start” button

Parkinson’s Disease (PD) and Other Movement Disorders- Part 5

Please wait while the activity loads.
If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled.

If loading fails, click here to try again

Start

Congratulations - you have completed Parkinson’s Disease (PD) and Other Movement Disorders- Part 5. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

Your answers are highlighted below.

Question 1

All of the following can aggravate essential tremors except ?

A	Valproic acid
B	Tricyclic antidepressants
C	Alcohol
D	Serotonin reuptake blockers

Question 1 Explanation:

Alcohol consumption reduces ET. Stress and drugs that can aggravate any tremor include valproic acid, lithium, beta-adrenergic agonists, methylxanthines, thyroxin, glucocorticoids, tricyclic antidepressants, and serotonin reuptake blockers.

Question 2

Association with which of the following gene is found in patients with young-onset ET ?

A	PLOD1 gene
B	LINGO1 gene
C	COL1A1 gene
D	TNXB gene

Question 2 Explanation:

Association with LINGO1 gene is found in patients with young-onset ET

Question 3

Drugs that have usefulness in treatment of essential tremors include all except ?

A	Primidone
B	Propranolol
C	Valproic acid
D	Gabapentin

Question 3 Explanation:

Primidone and propranolol are the first-line treatments for ET. Additional useful medications, with or without the primary agents, include benzodiazepines, gabapentin, topiramate, and botulinum toxin injections to affected muscle groups. Surgical therapies targeting the VIM nucleus of the thalamus can be very effective for severe and drug-resistant cases

Question 4

Which of the following statements is false about dystonia ?

A	Co-contraction of agonist and antagonist muscles
B	Appear during attempted voluntary movement
C	Exacerbated by stress and fatigue
D	None of the above

Question 4 Explanation:

Co-contraction of agonist and antagonist muscles is a fundamental feature of dystonia and characteristically present during attempted voluntary movement. Dystonia is exacerbated by stress and fatigue and attenuated by sensory inputs [touching affected body part (geste antagoniste)].

Question 5

Mutation in DYT1 gene on chromosome 9q34 results in which of the following dystonia ?

A	Dopa responsive dystonia (DRD)
B	Idiopathic torsion dystonia (ITD)
C	Myoclonic dystonia
D	Lubag form of dystonia-parkinsonism

Question 5 Explanation:

onset with autosomal dominant inheritance linked to a mutation in DYT1 gene located on chromosome 9q34 resulting in a trinucleotide GAG deletion with loss of one of a pair of glutamic acid residues in the protein torsin A.

Question 6

Any patient suspected of having a childhood-onset dystonia should receive a trial of ?

A	Valproate
B	Lithium
C	Levodopa
D	Serotonin reuptake blockers

Question 6 Explanation:

Any patient suspected of having a childhood-onset dystonia should receive a trial of levodopa to exclude Dopa responsive dystonia (DRD) or the Segawa variant (DYT5).

Question 7

Dystonia frequently accompanied by psychiatric disturbances goes in favour of ?

A	Idiopathic torsion dystonia (ITD)
B	Myoclonic dystonia
C	Lubag form of dystonia-parkinsonism
D	Dopa responsive dystonia (DRD)

Question 7 Explanation:

Myoclonic dystonia (DYT11) results from a mutation in epsilon-sarcoglycan gene on chromosome 7q21. It typically manifests as a combination of dystonia and myoclonic jerks, frequently accompanied by psychiatric disturbances

Question 8

Which of the following is a focal dystonia ?

A	Blepharospasm
B	Torticollis
C	Meige’s syndrome
D	All of the above

Question 8 Explanation:

Most common forms of dystonia are in adults - blepharospasm, cervical dystonias (torticollis, anterocollis, retrocollis), oromandibular dystonia, spasmodic dysphonia. The combination of lower facial and jaw dystonia is called Meige’s syndrome.

Question 9

Which of the following is a combination of oromandibular dystonia (OMD) and blepharospasm ?

A	Dopa responsive dystonia (DRD)
B	Idiopathic torsion dystonia (ITD)
C	Meige’s syndrome
D	Lubag form of dystonia-parkinsonism

Question 9 Explanation:

Meige syndrome is a combination of oromandibular dystonia (OMD) and blepharospasm

Question 10

Which of the following is is an x-linked recessive dystonia parkinsonism ?

A	Huntington’s disease
B	Lubag form of dystonia parkinsonism
C	Leigh’s disease
D	All of the above

Question 10 Explanation:

Lubag is an x-linked recessive dystonia parkinsonism that affects Filipino men originating principally from the Panay Island. Linkage analysis has confirmed the mode of inheritance and localized the disease gene to the proximal long arm of the x-chromosome.

Question 11

Dystonia can occur as a part of which neurodegenerative condition ?

A	HD
B	PD
C	Wilson’s disease
D	All of the above

Question 11 Explanation:

Dystonia plus syndromes refer to dystonia occuring as a part of neurodegenerative conditions like HD, PD, Wilson’s disease, CBGD, PSP, Lubag form of dystonia-parkinsonism (DYT3), and mitochondrial encephalopathies. Dystonia is usually not the dominant neurologic feature.

Question 12

Most effective treatment for generalized primary dystonia is ?

A	Primidone
B	Propranolol
C	Valproic acid
D	Anticholinergic drugs

Question 12 Explanation:

Anticholinergic drugs are the most effective forms of treatment for generalized primary dystonia

Question 13

Which of the following is most characteristic feature of HD ?

A	Gait disturbance
B	Chorea
C	Oculomotor abnormalities
D	Myoclonus

Question 13 Explanation:

HD is characterized by rapid, nonpatterned, semipurposeful, involuntary choreiform movements. Dysarthria, gait disturbance, and oculomotor abnormalities are common features. As disease progresses, chorea is reduced & dystonia, rigidity, bradykinesia, myoclonus, and spasticity emerge.

Question 14

Westphalt variant of Huntington’s disease (HD) relates to which of the following ?

A	Alzheimer’s disease
B	Parkinsonian syndrome
C	Orthostatic hypotension
D	Dementia

Question 14 Explanation:

HD can present as an akinetic-rigid or parkinsonian syndrome (Westphal variant).

Question 15

Which of the following is a typical MRI finding in Huntington’s Disease (HD) ?

A	Hypointensity of the caudate head
B	Progressive atrophy of caudate nuclei
C	Iron accumulation in striatum
D	Atrophy of the midbrain

Question 16

George Huntington belonged to which country ?

A	Great Britain
B	America
C	Australia
D	Canada

Question 16 Explanation:

Huntington’s disease (HD) was described by George Huntington, an American physician in 1872. Huntington’s gene is single, causal gene and an accurate genetic test for HD is available

Question 17

Huntington’s disease (HD) is caused by mutations in the Huntington’s gene on the ?

A	Short arm of chromosome 4
B	Long arm of chromosome 4
C	Short arm of chromosome 5
D	Long arm of chromosome 5

Question 17 Explanation:

HD is caused by mutations in the Huntington’s gene on the short arm of chromosome 4.

Question 18

Sydenham’s choreas responds to which of the following ?

A	Dopamine-blocking agents
B	Valproic acid
C	Carbamazepine
D	All of the above

Question 18 Explanation:

Sydenham’s chorea (St. Vitus’ dance) is of acute onset and responds to dopamine-blocking agents, valproic acid, and carbamazepine. Chorea may recur in later life, particularly in association with pregnancy (chorea gravidarum) or treatment with sex hormones.

Question 19

Disorders having excess brain iron accumulation on MRI include all except ?

A	Autosomal dominant neuroferritinopathy
B	Hallervorden-Spatz disease
C	Neuroacanthocytosis
D	Aceruloplasminemia

Question 19 Explanation:

Neurodegenerative diseases with brain iron accumulation (NBIA) manifesting with chorea include autosomal dominant neuroferritinopathy, autosomal recessive pantothenate-kinase-associated neurodegeneration (PKAN; Hallervorden-Spatz disease), and aceruloplasminemia. Iron accumulation in globus pallidus provides on MRI the characteristic “eye of the tiger” appearance

Question 20

Most common systemic disorder that causes chorea is ?

A	Hyperthyroidism
B	HIV disease
C	Systemic lupus erythematosus (SLE)
D	Polycythemia rubra vera

Question 20 Explanation:

Systemic lupus erythematosus is the most common systemic disorder that causes chorea. Choreas can also be seen with hyperthyroidism, Sjögren’s syndrome, HIV disease, metabolic alterations, polycythemia rubra vera, with many medications (anticonvulsants, cocaine, CNS stimulants, estrogens, lithium) and paraneoplastic syndromes associated with anti-CRMP-5 or anti-Hu antibodies.

Question 21

In hemiballismus, most often the lesion is in ?

A	Globus pallidus
B	Cerebellum
C	Subthalamic nucleus
D	Pedunculopontine nucleus

Question 21 Explanation:

Most common cause of hemiballismus is a lesion (infarct or hemorrhage) of subthalamic nucleus (STN) and rarely in putamen.

Question 22

Which of the following best relates to hemiballismus ?

A	Chorea
B	Athetosis
C	Choreoathetosis
D	Any of the above

Question 22 Explanation:

Hemiballismus is a violent form of chorea composed of wild, flinging, large-amplitude movements of proximal limb muscles on one side of the body.

Question 23

Which of the following is a neurobehavioral disorder ?

A	Essential tremor (ET)
B	Wilson’s disease
C	Huntington’s disease (HD)
D	Tourette’s Syndrome (TS)

Question 23 Explanation:

Tourette’s Syndrome (TS) is a neurobehavioral disorder named after French neurologist Georges Gilles de la Tourette.

Question 24

Associated behavioral disturbance with Tourette’s Syndrome (TS) include ?

A	Anxiety, depression
B	Attention deficit hyperactivity disorder
C	Obsessive-compulsive disorder
D	All of the above

Question 24 Explanation:

Associated behavioral disturbances with Tourette’s Syndrome (TS) include anxiety, depression, attention deficit hyperactivity disorder, and obsessive-compulsive disorder.

Question 25

Which of the following is a kind of vocal tic ?

A	Echolalia
B	Palilalia
C	Coprolalia
D	All of the above

Question 25 Explanation:

Vocal tics include grunting, echolalia (repeating other people’s words), palilalia (repeating one’s own words), and coprolalia (expression of obscene words).

Once you are finished, click the button below. Any items you have not completed will be marked incorrect. Get Results

There are 25 questions to complete.

←

List

→

Return

Shaded items are complete.

1	2	3	4	5
6	7	8	9	10
11	12	13	14	15
16	17	18	19	20
21	22	23	24	25
End

Return

See all quizzes of Parkinson’s Disease (PD) and Other Movement Disorders at here:

Parkinson’s Disease (PD) and Other Movement Disorders- Part 1| Parkinson’s Disease (PD) and Other Movement Disorders- Part 2| Parkinson’s Disease (PD) and Other Movement Disorders- Part 3| Parkinson’s Disease (PD) and Other Movement Disorders- Part 4|Parkinson’s Disease (PD) and Other Movement Disorders- Part 5|Parkinson’s Disease (PD) and Other Movement Disorders- Part 6

1 All of the following can aggravate essential tremors except ?
A. Valproic acid
B. Tricyclic antidepressants
C. Alcohol
D. Serotonin reuptake blockers
\
2 Association with which of the following gene is found in patients
with young-onset ET ?
A. PLOD1 gene
B. LINGO1 gene
C. COL1A1 gene
D. TNXB gene

3 Drugs that have usefulness in treatment of essential tremors
include all except ?
A. Primidone
B. Propranolol
C. Valproic acid
D. Gabapentin

4 Which of the following statements is false about dystonia ?
A. Co-contraction of agonist and antagonist muscles
B. Appear during attempted voluntary movement
C. Exacerbated by stress and fatigue
D. None of the above

5 Mutation in DYT1 gene on chromosome 9q34 results in which of
the following dystonia ?
A. Dopa responsive dystonia (DRD)
B. Idiopathic torsion dystonia (ITD)
C. Myoclonic dystonia
D. Lubag form of dystonia-parkinsonism

6 Any patient suspected of having a childhood-onset dystonia should
receive a trial of ?
A. Valproate
B. Lithium
C. Levodopa
D. Serotonin reuptake blockers

7 Dystonia frequently accompanied by psychiatric disturbances goes
in favour of ?
A. Idiopathic torsion dystonia (ITD)
B. Myoclonic dystonia
C. Lubag form of dystonia-parkinsonism
D. Dopa responsive dystonia (DRD)

8 Which of the following is a focal dystonia ?
A. Blepharospasm
B. Torticollis
C. Meige’s syndrome
D. All of the above

9 Which of the following is a combination of oromandibular dystonia
(OMD) and blepharospasm ?
A. Dopa responsive dystonia (DRD)
B. Idiopathic torsion dystonia (ITD)
C. Meige’s syndrome
D. Lubag form of dystonia-parkinsonism

10 Which of the following is is an x-linked recessive dystonia
parkinsonism ?
A. Huntington’s disease
B. Lubag form of dystonia parkinsonism
C. Leigh’s disease
D. All of the above

11 Dystonia can occur as a part of which neurodegenerative condition ?
A. HD
B. PD
C. Wilson’s disease
D. All of the above

12 Most effective treatment for generalized primary dystonia is ?
A. Primidone
B. Propranolol
C. Valproic acid
D. Anticholinergic drugs

13 Which of the following is most characteristic feature of HD ?
A. Gait disturbance
B. Chorea
C. Oculomotor abnormalities
D. Myoclonus

14 Westphalt variant of Huntington’s disease (HD) relates to which of
the following ?
A. Alzheimer’s disease
B. Parkinsonian syndrome
C. Orthostatic hypotension
D. Dementia

15 Which of the following is a typical MRI finding in Huntington’s
Disease (HD) ?
A. Hypointensity of the caudate head
B. Progressive atrophy of caudate nuclei
C. Iron accumulation in striatum
D. Atrophy of the midbrain

16 George Huntington belonged to which country ?
A. Great Britain
B. America
C. Australia
D. Canada

17 Huntington’s disease (HD) is caused by mutations in the
Huntington’s gene on the ?
A. Short arm of chromosome 4
B. Long arm of chromosome 4
C. Short arm of chromosome 5
D. Long arm of chromosome 5

18 Sydenham’s choreas responds to which of the following ?
A. Dopamine-blocking agents
B. Valproic acid
C. Carbamazepine
D. All of the above

19 Disorders having excess brain iron accumulation on MRI include
all except ?
A. Autosomal dominant neuroferritinopathy
B. Hallervorden-Spatz disease
C. Neuroacanthocytosis
D. Aceruloplasminemia

20 Most common systemic disorder that causes chorea is ?
A. Hyperthyroidism
B. HIV disease
C. Systemic lupus erythematosus (SLE)
D. Polycythemia rubra vera

21 In hemiballismus, most often the lesion is in ?
A. Globus pallidus
B. Cerebellum
C. Subthalamic nucleus
D. Pedunculopontine nucleus

22 Which of the following best relates to hemiballismus ?
A. Chorea
B. Athetosis
C. Choreoathetosis
D. Any of the above

23 Which of the following is a neurobehavioral disorder ?
A. Essential tremor (ET)
B. Wilson’s disease
C. Huntington’s disease (HD)
D. Tourette’s Syndrome (TS)

24 Associated behavioral disturbance with Tourette’s Syndrome (TS)
include ?
A. Anxiety, depression
B. Attention deficit hyperactivity disorder
C. Obsessive-compulsive disorder
D. All of the above

25 Which of the following is a kind of vocal tic ?
A. Echolalia
B. Palilalia
C. Coprolalia
D. All of the above

Parkinson’s Disease (PD) and Other Movement Disorders

[MCQ] Parkinson’s Disease (PD) and Other Movement Disorders- Part 5

I. Start the exam by click the “Start” button

Parkinson’s Disease (PD) and Other Movement Disorders- Part 5

Share this:

Related

[MCQ] Parkinson’s Disease (PD) and Other Movement Disorders- Part 4

[MCQ] Parkinson’s Disease (PD) and Other Movement Disorders- Part 6

You may also like

Leave a Comment Cancel Reply