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Paget’s Disease and Other Dysplasias of Bone
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1 Number of nuclei in the normal osteoclast is ?
A. 1 – 3
B. 3 – 5
C. 5 – 8
D. 8 – 12
2 Principal abnormality in Paget disease is ?
A. Increased number of osteoclasts
B. Increased activity of osteoclasts
C. Increased size of osteoclasts
D. All of the above
3 In Paget disease of bone, which of the following is the most
common presenting symptom ?
A. Pain
B. Paresthesias
C. Diplopia
D. Warmth over underlying pagetic lesion
4 Which of the following is a marker of bone resorption ?
A. Urinary Oxypyridinoline
B. Urinary pyridinoline
C. Urinary deoxypyridinoline
D. All of the above
5 Inheritance of Juvenile Paget’s disease is ?
A. Autosomal recessive
B. Autosomal dominant
C. X linked
D. Any of the above
6 Howship’s lacunae is related to which of the following ?
A. Osteoclast development
B. Osteoclast-mediated resorption of bone
C. Osteoblast progenitors
D. Osteoclast progenitors
7 Gene which encodes osteoprotegrin is ?
A. TNFRSF11A
B. TNFRSF11B
C. TNFRSF11C
D. TNFRSF11D
.
8 Which of the following is a marker of bone formation ?
A. Serum ALP
B. Serum AST
C. Urinary hydroxyproline
D. All of the above
9 Which of the following is a product of type I collagen
degradation ?
A. Serum deoxypyridinoline
B. Serum N-telopeptide
C. Serum C-telopeptide
D. All of the above
10 Which of the following is not a urine or serum bone resorption
marker ?
A. Deoxypyridinoline
B. Osteocalcin
C. N-telopeptide
D. C-telopeptide
11 Which of the following is an intravenous bisphosphonate ?
A. Zoledronic acid
B. Olpadronate
C. Pamidronate
D. All of the above
Intravenous bisphosphonates are pamidronate, zoledronic acid & olpadronate.
12 Which of the following is an intravenous bisphosphonate ?
A. Etidronate disodium
B. Tiludronate disodium
C. Risedronate sodium
D. None of the above
13 Potencies of various bisphosphonates are expressed relative to
that of ?
A. Alendronate
B. Risedronate
C. Pamidronate
D. Etidronate
14 Which of the following is a 1st generation oral bisphosphonate ?
A. Tiludronate
B. Alendronate
C. Risedronate
D. Etidronate
15 Radiographic finding of Paget disease include ?
A. Osteoporosis circumscripta
B. Picture frame vertebra
C. Ivory vertebra
D. All of the above
16 Brim sign refers to ?
A. Thickening of diploic skull areas
B. Thickened & sclerotic ileopectinal line
C. Vertebral cortical thickening
D. Diffuse radiodense enlargement of a vertebra
