[MCQ] Malaria-Dengue fever- Part 1

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Malaria-Dengue fever- Part 1

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Question 1

Which of the following statements about Dengue fever is false ?

A	Self-limited illness
B	Systemic viral infection
C	Transmitted to humans by mosquitoes
D	None of the above

Question 1 Explanation:

Dengue is a self-limited, systemic viral infection transmitted to humans by mosquitoes

Question 2

Globally, about how many countries are affected by dengue ?

A	50
B	100
C	150
D	200

Question 2 Explanation:

An estimated 50 million infections per year occur across ~100 countries

Question 3

Dengue is said to have emerged from ?

A	Africa
B	Latin America
C	South East Asia
D	Australia

Question 4

Which of the following is related to Dengue ?

A	Aedes albopictus
B	Aedes triseriatus
C	Culex tritaeniorhynchus
D	Culex tarsalis

Question 4 Explanation:

In recent years, a secondary vector, Aedes albopictus, has dramatically expanded Dengue spread from Asia to United States, Indian Ocean, and parts of Europe.

Question 5

Which of the following is best related to dengue spread ?

A	Urban migration
B	Textile trade
C	Trade of tires from used vehicles
D	Global warming

Question 5 Explanation:

Globalization of trade, particularly trade of tires from used vehicles, explains the dispersal of eggs & immature forms of these arboviral vectors into new territories.

Question 6

Aedes aegypti is an efficient vector of ?

A	Yellow fever
B	Chikungunya virus
C	Dengue virus
D	All of the above

Question 7

Which of the following is a Flavivirus ?

A	Yellow fever
B	Japanese encephalitis
C	Dengue
D	All of the above

Question 8

Which of the following about A. aegypti is false ?

A	Typically breeds near human habitation
B	Breeds using relatively fresh water
C	Bites during the day
D	None of the above

Question 8 Explanation:

Aedes aegypti mosquitotypically breeds near human habitation, using relatively fresh water, and bites during the day.

Question 9

Incubation period of Dengue fever is ?

A	1 to 2 days
B	2 to 7 days
C	10 to 14 days
D	14 to 21 days

Question 9 Explanation:

Incubation period of Dengue fever is 2 - 7 days.

Question 10

“Break-bone fever” is suggestive of ?

A	Lyme disease
B	Relapsing fever
C	Typhoid fever
D	Dengue fever

Question 11

Which of the following is central to pathogenesis of dengue fever and DHF/DSS ?

A	Protective antiviral antibodies
B	Macrophage/monocyte infection
C	T cell non-reactivity
D	All of the above

Question 12

Which of the following is best related to dengue ?

A	Heparan sulfate
B	Keratan sulfate
C	Ceramide
D	Sphingomyelin

Question 12 Explanation:

Preliminary data suggest that in dengue fever, transient disruption in the function of endothelial glycocalyx layer occurs bringing about crucial change in the filtration characteristics of the glycocalyx. Both the virus itself and dengue NS1 are known to adhere to heparan sulfate, a key structural element of the glycocalyx, and increased urinary heparan sulfate excretion has been detected in children with severe infection.

Question 13

Which of the following condition is required to label a case of dengue as severe dengue ?

A	Plasma leakage resulting in shock
B	Severe bleeding
C	Severe organ impairment
D	All of the above

Question 13 Explanation:

Severe dengue refers to plasma leakage resulting in shock, accumulation of serosal fluid sufficient to cause respiratory distress, or both; severe bleeding; and severe organ impairment

Question 14

Which of the following is false about dengue fever ?

A	Zoonotic illness
B	Urban vector
C	Most common arboviral disease worldwide
D	None of the above

Question 14 Explanation:

Viral hemorrhagic fevers are zoonotic illnesses caused by viruses that reside in arthropod urban vectors. Dengue is the most common arboviral disease worldwide. Patients have a triad of symptoms - hemorrhagic manifestations, evidence of plasma leakage, and platelet counts <100,000/μL.

Question 15

Which infecting serotype of dengue virus is most dangerous ?

A	Type 1
B	Type 2
C	Type 3
D	Type 4

Question 15 Explanation:

Type 2 (especially Southeast Asian) is more dangerous than other dengue serotypes with more potential to cause DHF/DSS. Serotype 1 followed by serotype 2 is more dangerous than serotype 4 followed by serotype 2

Question 16

Which of the following is not a phase of dengue fever ?

A	Initial afebrile phase
B	Initial febrile phase
C	Critical phase around defervescence
D	Spontaneous recovery phase

Question 16 Explanation:

Three phases of dengue fever are an initial febrile phase, a critical phase around the time of defervescence, and a spontaneous recovery phase. Systemic vascular leak syndrome becomes apparent around the time of defervescence (days 4 and 7 of the illness), evidenced by increasing hemoconcentration, hypoproteinemia, pleural effusions, and ascites.

Question 17

Warning signs that clinically significant vascular leakage may be developing in dengue patient include ?

A	Persistent vomiting
B	High or increasing hematocrit level
C	Pulse pressure of 20 mm Hg or less
D	All of the above

Question 17 Explanation:

Warning signs that clinically significant vascular leakage may be developing in dengue patient include persistent vomiting, increasingly severe abdominal pain, tender hepatomegaly, a high or increasing hematocrit level that is concurrent with a rapid decrease in the platelet count, serosal effusions, mucosal bleeding, and lethargy or restlessness. If the pulse pressure narrows to 20 mm Hg or less, accompanied by signs of peripheral vascular collapse, dengue shock syndrome is diagnosed. Moderate to severe thrombocytopenia is common, with nadir platelet counts below 20000 per microliter often observed during the critical phase, followed by rapid improvement during the recovery phase.

Question 18

Which of the following about DHF/DSS is false ?

A	Susceptibility drops after 12 years of age
B	Females are more often affected than males
C	Malnutrition is protective
D	None of the above

Question 18 Explanation:

Susceptibility to DHF/DSS drops after 12 years of age, females are more often affected than males, malnutrition is protective

Question 19

Dengue hemorrhagic fever causes which of the following ?

A	MPGN
B	Focal glomerulonephritis
C	Endocapillary proliferative glomerulonephritis
D	Diffuse proliferative nephritis

Question 19 Explanation:

Viral infections and their respective glomerular lesions include: CMV - MPGN; measles - endocapillary proliferative glomerulonephritis, parvovirus - mesangioproliferative glomerulonephritis, mumps - mesangioproliferative glomerulonephritis, Epstein-Barr virus - MPGN, dengue hemorrhagic fever - endocapillary proliferative glomerulonephritis, and coxsackie virus - focalglomerulonephritis

Question 20

After an infected mosquito bites person, the dengue virus replicates in ?

A	Regional lymph nodes
B	Bone marrow
C	Spleen
D	Liver

Question 20 Explanation:

After an infected mosquito bites a person, virus replicates in regional lymph nodes and is disseminated through lymphatic system & blood to other tissues.

Question 21

A person may be infected with dengue virus for a maximum of ?

A	Once
B	Twice
C	Thrice
D	Four times

Question 21 Explanation:

Infection with one Dengue serotype confers long-term immunity only to that serotype and therefore persons may be infected up to four times.

Question 22

Which of the following is a risk factor for severe dengue ?

A	Young age
B	Female sex
C	High body-mass index
D	All of the above

Question 22 Explanation:

Epidemiologic studies have identified young age, female sex, high body-mass index, virus strain, and genetic variants of the human major-histocompatibility-complex class I-related sequence B and phospholipase C epsilon 1 genes as risk factors for severe dengue. Secondary infection, i.e. two sequential infections by different serotypes, is also an epidemiologic risk factor for severe disease.

Question 23

Main risk factor for development of DHF / DSS is ?

A	Strain and serotype of the infecting virus
B	Secondary infection with another serotype
C	Age and genetic background of patient
D	Degree of viremia

Question 23 Explanation:

Main risk factor for development of dengue hemorrhagic fever & dengue shock syndrome is secondary infection with another serotype.

Question 24

Petechiae DHF/DSS are best visualized in ?

A	Groin
B	Palm
C	Axillae
D	Nape of the neck

Question 24 Explanation:

Petechiae DHF/DSS are best visualized in axillae

Question 25

In dengue fever, skin rash occurs in what proportion of cases ?

A	25 %
B	50 %
C	75 %
D	100 %

Question 26

In dengue fever, the kind of skin rash is ?

A	Macular
B	Papular
C	Maculopapular
D	Pustular

Question 27

In dengue fever, the skin rash begins on ?

A	Face
B	Extremities
C	Trunk
D	Neck

Question 27 Explanation:

In dengue fever, skin rash occurs in 50% of cases. To start with its a diffuse flushing, midway through illness, it is maculopapular rash, beginning on trunk & spreads centrifugally to extremities and face, after defervescence, petechiae on extremities may occur. A second rash may appear during recovery phase, ranging from mild maculopapular rash to severe, itchy lesion suggesting leukocytoclastic vasculitis that resolves with desquamation over a period of 1 to 2 weeks.

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See all quizzes of Malaria-Dengue fever- Part 1 here:

1 Which of the following statements about Dengue fever is false ?
A. Self-limited illness
B. Systemic viral infection
C. Transmitted to humans by mosquitoes
D. None of the above

2 Globally, about how many countries are affected by dengue ?
A. 50
B. 100
C. 150
D. 200

3 Dengue is said to have emerged from ?
A. Africa
B. Latin America
C. South East Asia
D. Australia

4 Which of the following is related to Dengue ?
A. Aedes albopictus
B. Aedes triseriatus
C. Culex tritaeniorhynchus
D. Culex tarsalis

5 Which of the following is best related to dengue spread ?
A. Urban migration
B. Textile trade
C. Trade of tires from used vehicles
D. Global warming

6 Aedes aegypti is an efficient vector of ?
A. Yellow fever
B. Chikungunya virus
C. Dengue virus
D. All of the above
7 Which of the following is a Flavivirus ?
A. Yellow fever
B. Japanese encephalitis
C. Dengue
D. All of the above
8 Which of the following about A. aegypti is false ?
A. Typically breeds near human habitation
B. Breeds using relatively fresh water
C. Bites during the day
D. None of the above

9 Incubation period of Dengue fever is ?
A. 1 to 2 days
B. 2 to 7 days
C. 10 to 14 days
D. 14 to 21 days
.
10 “Break-bone fever” is suggestive of ?
A. Lyme disease
B. Relapsing fever
C. Typhoid fever
D. Dengue fever

11 Biphasic “saddleback” fever is suggestive of ?
A. Lyme disease
B. Relapsing fever
C. Typhoid fever
D. Dengue fever
12 Which of the following is central to pathogenesis of dengue fever
and DHF/DSS ?
A. Protective antiviral antibodies
B. Macrophage/monocyte infection
C. T cell non-reactivity
D. All of the above

13 Which of the following is best related to dengue ?
A. Heparan sulfate
B. Keratan sulfate
C. Ceramide
D. Sphingomyelin

14 Which of the following condition is required to label a case of
dengue as severe dengue ?
A. Plasma leakage resulting in shock
B. Severe bleeding
C. Severe organ impairment
D. All of the above

15 Which of the following is false about dengue fever ?
A. Zoonotic illness
B. Urban vector
C. Most common arboviral disease worldwide
D. None of the above

16 Which infecting serotype of dengue virus is most dangerous ?
A. Type 1
B. Type 2
C. Type 3
D. Type 4

17 Which of the following is not a phase of dengue fever ?
A. Initial afebrile phase
B. Initial febrile phase
C. Critical phase around defervescence
D. Spontaneous recovery phase

18 Warning signs that clinically significant vascular leakage may be
developing in dengue patient include ?
A. Persistent vomiting
B. High or increasing hematocrit level
C. Pulse pressure of 20 mm Hg or less
D. All of the above

19 Which of the following about DHF/DSS is false ?
A. Susceptibility drops after 12 years of age
B. Females are more often affected than males
C. Malnutrition is protective
D. None of the above

20 Dengue hemorrhagic fever causes which of the following ?
A. MPGN
B. Focal glomerulonephritis
C. Endocapillary proliferative glomerulonephritis
D. Diffuse proliferative nephritis

21 After an infected mosquito bites person, the dengue virus replicates
in ?
A. Regional lymph nodes
B. Bone marrow
C. Spleen
D. Liver

22 A person may be infected with dengue virus for a maximum of ?
A. Once
B. Twice
C. Thrice
D. Four times

23 Which of the following is a risk factor for severe dengue ?
A. Young age
B. Female sex
C. High body-mass index
D. All of the above

24 Main risk factor for development of DHF / DSS is ?
A. Strain and serotype of the infecting virus
B. Secondary infection with another serotype
C. Age and genetic background of patient
D. Degree of viremia

25 Petechiae DHF/DSS are best visualized in ?
A. Groin
B. Palm
C. Axillae
D. Nape of the neck

26 In dengue fever, skin rash occurs in what proportion of cases ?
A. 25 %
B. 50 %
C. 75 %
D. 100 %
27 In dengue fever, the kind of skin rash is ?
A. Macular
B. Papular
C. Maculopapular
D. Pustular
28 In dengue fever, the skin rash begins on ?
A. Face
B. Extremities
C. Trunk
D. Neck

Malaria-Dengue fever

[MCQ] Malaria-Dengue fever- Part 1

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Malaria-Dengue fever- Part 1

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