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HIV / AIDS- Part 7
See all quizzes of HIV / AIDS- Part 7 here:
1 Which of the following is a major co-stimulatory molecule
necessary for the normal activation of T cells ?
A. CD20
B. CD28
C. CD38
D. CD45RO
2 Markers of terminal activation include ?
A. HLA-DR
B. CD38
C. CD45RO
D. All of the above
3 Which of the following contribute to the dysregulation of B cell
function seen in HIV disease ?
A. CD20 ligand
B. CD40 ligand
C. CD60 ligand
D. CD80 ligand
4 T-regs refers to ?
Harrison’s 18th Ed. 1529
A. T regulatory cells
B. T registry cells
C. T regenerating cells
D. T recognizing cells
5 Which cells constitute a long-term reservoir of potentially infectious
virus ?
A. CD8+ T cells
B. CD4+ T cells
C. B Lymphocyte
D. Macrophage
6 Predominantly infected cell population in HIV infection is ?
A. Memory CD4+ T cells
B. Naive CD4+ T cells
C. Proliferating CD4+ T cells
D. Activated CD4+ T cells
7 HIV replicates most efficiently in ?
A. Memory CD4+ T cells
B. Naive CD4+ T cells
C. Proliferating CD4+ T cells
D. Activated CD4+ T cells
8 Pool of infected quiescent T cells called “latent reservoir” is
formed by ?
A. CD4+ T-cell
B. CD8+ T-cell
C. B Lymphocyte
D. Macrophage
9 ADCC refers to ?
A. Antibody-dependent cellular cytotoxicity
B. Antigen-dependent cellular cytotoxicity
C. Antibody-derived cellular cytotoxicity
D. Antigen-derived cellular cytotoxicity
10 Strain differences in single-cell killing are determined by ?
A. gp41 sequences
B. gp120 sequences
C. gp160 sequences
D. All of the above
11 Which of the following relate to bystander killing ?
A. Anti-gp120 antibodies
B. Uninfected CD4+ T cells
C. Free gp120
D. All of the above
12 HIV infected individuals whose CD8+ T cells developed which
phenotype after seroconversion have a more aggressive course
and a poorer prognosis ?
A. HLA-DR+/CD38+
B. HLA-DR+/CD38-
C. HLA-DR-/CD38+
D. HLA-DR-/CD38-
13 The main cell type infected with HIV in the brain is ?
A. Oligodendrocytes
B. Neurons
C. Microglial cells
D. Astrocytes
14 Elevated levels of which of the following in the brain & CSF correlate
best with the presence & degree of HIV encephalopathy ?
A. Vasoactive intestinal peptide (VIP)
B. Monocyte chemotactic protein (MCP)1
C. IL-1
D. All of the above
15 Moritz Kaposi had which nationality ?
N Engl J Med 2000;342:1027
A. German
B. Italian
C. Hungarian
D. Polish
16 Which of the following variant of Kaposi’s sarcoma is AIDS
associated ?
A. Classic
B. Endemic
C. Immunosuppression or transplantation-associated
D. Epidemic
17 Which of the following does not belong to the Herpesviridae
family ?
A. Varicella-zoster virus
B. Epstein-Barr virus
C. Coxsackievirus
D. Cytomegalovirus
18 Colour of papules & plaques seen in Kaposi’s sarcoma is ?
A. Purple
B. Black
C. Brown
D. Yellow
19 Which of the following best relates to Kaposi’s sarcoma ?
A. Herpes simplex virus
B. Helicobacter pylori
C. Human herpes virus 8 (HHV-8)
D. Cytomegalovirus
20 Kaposi’s sarcoma–associated herpesvirus (KSHV) is the other
name of ?
A. Human herpes virus 6 (HHV-6)
B. Human herpes virus 7 (HHV-7)
C. Human herpes virus 8 (HHV-8)
D. All of the above
21 Human herpes virus 8 (HHV-8) is related to ?
A. Cytomegalovirus
B. Epstein-Barr virus (EBV)
C. Herpes simplex virus
D. Varicella-zoster virus
22 Kaposi’s sarcoma (KS) is a ?
A. Neoplastic sarcoma
B. Lymphoproliferative disease
C. Angioproliferative disease
D. Granulomatous disease
23 Human herpes virus 8 (HHV-8) causes ?
A. Body cavity lymphoma
B. Multiple myeloma
C. Monoclonal gammopathy of undetermined significance
D. All of the above
24 Multiple vascular nodules in Kaposi’s sarcoma appear in ?
A. Skin
B. Mucous membranes
C. Viscera
D. All of the above
25 Which of the following about Kaposi’s sarcoma is false ?
A. May appear at any stage of HIV infection
B. Koebner phenomenon +
C. Initial lesion may be swollen lymph node
D. None of the above
