[MCQ] HIV / AIDS- Part 6

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HIV / AIDS- Part 6

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Congratulations - you have completed HIV / AIDS- Part 6. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

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Question 1

SDF stands for ?

A	Stromal cell dependent factor
B	Stromal cell derived factor
C	Stromal cell deficient factor
D	Stromal cell dominant factor

Question 1 Explanation:

Stromal cell derived factor (SDF) 1 inhibits infection by & spread of X4 strains by blocking the binding of the HIV virus to its co-receptor CXC-chemokine receptor CXCR4. SDF-1 is the natural ligand for CXCR4.

Question 2

RANTES stands for ?

A	Regulated upon activation normal T-cell expressed & secreted
B	Released upon activation normal T-cell expressed & secreted
C	Reduced upon activation normal T-cell expressed & secreted
D	Receptor upon activation normal T-cell expressed & secreted

Question 2 Explanation:

CC-chemokines RANTES (CCL5), MIP-1 (CCL3), and MIP-1 (CCL4) inhibit infection of R5 strains of HIV by blocking the binding of HIV virus to its co-receptors, the CC-chemokine receptor CCR5.

Question 3

Which of the following cytokine inhibits both R5 and X4 strains of HIV viruse ?

A	RANTES
B	SDF-1
C	Alpha defensin
D	All of the above

Question 3 Explanation:

The alpha defensin family of cytokines inhibits both R5 and X4 viruses.

Question 4

Which of the following is not a family of chemotactic cytokines or chemokines ?

A	CC chemokines
B	CXC chemokines
C	CX2C chemokines
D	CX3C chemokine

Question 5

Interleukin-8 is the prototype member of which chemokine family ?

A	CC
B	CXC
C	CX3C
D	XCL1

Question 6

Fractalkine is a member of which chemokine family ?

A	CC chemokines
B	CXC chemokines
C	CX3C chemokines
D	XCL1 chemokine

Question 7

Lymphotactin is a member of which chemokine family ?

A	CC chemokines
B	CXC chemokines
C	CX3C chemokines
D	XCL1 chemokine

Question 8

HLA complex is located on ?

A	Chromosome 3
B	Chromosome 6
C	Chromosome 9
D	Chromosome 12

Question 8 Explanation:

Human major histocompatibility complex (MHC), also called human leukocyte antigen (HLA) complex, is a 4-megabase (Mb) region on chromosome 6 (6p21.3). It is densely packed with expressed genes of which the best known are HLA class I & class II genes, whose products are critical for immunologic specificity & transplantation histocompatibility.

Question 9

In WHO nomenclature, HLA class I alleles are given a single designation that indicates ?

A	Locus
B	Serologic specificity
C	Sequence-based subtype
D	All of the above

Question 10

The original name of CXCR4 was ?

A	Fusin
B	Inhibin
C	Integrin
D	Catalin

Question 11

Which of the following is called syncytium-inducing HIV virus ?

A	R5 virus
B	X4 virus
C	R5X4 virus
D	All of the above

Question 12

In HIV, increased turnover of which lymphocyte is seen ?

A	CD4+ T lymphocytes
B	CD8+ T lymphocytes
C	B lymphocytes
D	All of the above

Question 13

TRECs refer to ?

A	T cell receptor emptying circles
B	T cell receptor excision cycles
C	T cell receptor excision circles
D	T cell receptor emptying cycles

Question 13 Explanation:

T cell receptor excision circles (TRECs) are a byproduct of T cell development & represent episomal fragments of DNA that are excised during T cell receptor gene rearrangement. TRECs increase following initiation of ARV therapy.

Question 14

Strains of HIV that utilize CCR5 as a co-receptor are called ?

A	CCR5 viruses
B	CR5 viruses
C	R5 viruses
D	All of the above

Question 14 Explanation:

HIV-1 utilizes two major co-receptors along with CD4 to bind to, fuse with, and enter target cells. These co-receptors are CCR5 and CXCR4. Strains of HIV that utilize CCR5 as a co-receptor are referred to as R5 viruses.

Question 15

Strains of HIV that utilize CXCR4 as a co-receptor are called ?

A	R4 viruses
B	CR4 viruses
C	XCR4 viruses
D	X4 viruses

Question 15 Explanation:

Strains of HIV that utilize CXCR4 are referred to as X4 viruses.

Question 16

Strains of HIV that utilize both CCR5 and CXCR4 as co-receptors are referred to as ?

A	R5X4 viruses
B	X4R5 viruses
C	5R4X viruses
D	R54X viruses

Question 16 Explanation:

HIV virus strains that utilize both CCR5 and CXCR4 are referred to as R5X4 viruses.

Question 17

Which of the following is the transmitting strain of HIV ?

A	R5 virus
B	X4 virus
C	R5X4 virus
D	All of the above

Question 17 Explanation:

Transmitting virus is almost invariably an R5 virus that predominates during early stages of HIV disease.

Question 18

In what percentage of HIV-infected individuals, there is a transition from R5 to X4 virus ?

A	~ 20 %
B	~ 40 %
C	~ 60 %
D	~ 80 %

Question 18 Explanation:

In ~40% of HIV-infected individuals, there is a transition to a predominantly X4 virus that is associated with a relatively rapid progression of disease.

Question 19

Which of the following subtypes, or clades of HIV-1 M group virus almost never switch from CCR5 to CXCR4 tropism ?

A	A
B	B
C	C
D	D

Question 19 Explanation:

C subtypes, or clades of HIV-1 M group viruses almost never switch from CCR5 to CXCR4 tropism

Question 20

The natural chemokine ligands for HIV co-receptor CCR5 are all except ?

A	RANTES (CCL5)
B	MIP-1alpha (CCL3)
C	MIP-1beta (CCL4)
D	SDF-1

Question 20 Explanation:

The natural chemokine ligands for HIV co-receptor CCR5 are the CC-chemokines RANTES (CCL5), MIP-1alpha (CCL3), and MIP-1beta (CCL4). They block entry of R5 viruses

Question 21

Natural chemokine ligands for HIV co-receptor CXCR4 is ?

A	RANTES (CCL5)
B	MIP-1alpha (CCL3)
C	MIP-1beta (CCL4)
D	SDF-1

Question 21 Explanation:

SDF-1 is the natural ligand for CXCR4. It blocks the entry of X4 viruses.

Question 22

Which of the following is also a co-receptors for HIV ?

A	CCR2
B	CCR3
C	GPR1
D	All of the above

Question 22 Explanation:

Apart from CCR5 and CXCR4, other co-receptors for HIV entry also include CCR3, BOB/GPR15, CXCR6 (Bonzo/STRL33/TYMSTR), CCR2, CCR8, CX3CR1(V28) and GPR1.

Question 23

Which of the following is the macrophage-tropic strain of HIV ?

A	R5 virus
B	X4 virus
C	R5X4 virus
D	All of the above

Question 23 Explanation:

R5 is the macrophage-tropic strains of HIV. They are more efficient in infecting monocytes/ macrophages & microglial cells of brain.

Question 24

Individuals with which of the following are protected against HIV infection ?

A	Homozygous for CCR5-32 deletion
B	Heterozygous for the CCR2-64I mutation
C	RANTES-28G mutation
D	All of the above

Question 25

One of the first immune defects detected in HIV disease is ?

A	Defective T cell cloning & colony-forming efficiencies
B	Decreased IFN- production in response to antigens
C	Defect in response to remote recall antigens
D	Response to mitogenic stimulation

Question 25 Explanation:

One of the first abnormalities to be detected is a defect in response to remote recall antigens, such as tetanus toxoid and influenza.

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See all quizzes of HIV / AIDS- Part 6 here:

1 SDF stands for ?
A. Stromal cell dependent factor
B. Stromal cell derived factor
C. Stromal cell deficient factor
D. Stromal cell dominant factor

2 RANTES stands for ?
A. Regulated upon activation normal T-cell expressed & secreted
B. Released upon activation normal T-cell expressed & secreted
C. Reduced upon activation normal T-cell expressed & secreted
D. Receptor upon activation normal T-cell expressed & secreted
3 Which of the following cytokine inhibits both R5 and X4 strains of
HIV viruse ?
A. RANTES
B. SDF-1
C. Alpha defensin
D. All of the above

4 Which of the following is not a family of chemotactic cytokines or
chemokines ?
A. CC chemokines
B. CXC chemokines
C. CX2C chemokines
D. CX3C chemokine
5 Interleukin-8 is the prototype member of which chemokine
family ?
A. CC
B. CXC
C. CX3C
D. XCL1
6 Fractalkine is a member of which chemokine family ?
A. CC chemokines
B. CXC chemokines
C. CX3C chemokines
D. XCL1 chemokine
7 Lymphotactin is a member of which chemokine family ?
A. CC chemokines
B. CXC chemokines
C. CX3C chemokines
D. XCL1 chemokine
8 HLA complex is located on ?
A. Chromosome 3
B. Chromosome 6
C. Chromosome 9
D. Chromosome 12

9 In WHO nomenclature, HLA class I alleles are given a single
designation that indicates ?
A. Locus
B. Serologic specificity
C. Sequence-based subtype
D. All of the above
10 The original name of CXCR4 was ?
A. Fusin
B. Inhibin
C. Integrin
D. Catalin
11 Which of the following is called syncytium-inducing HIV virus ?
A. R5 virus
B. X4 virus
C. R5X4 virus
D. All of the above
12 In HIV, increased turnover of which lymphocyte is seen ?
A. CD4+ T lymphocytes
B. CD8+ T lymphocytes
C. B lymphocytes
D. All of the above
13 TRECs refer to ?
A. T cell receptor emptying circles
B. T cell receptor excision cycles
C. T cell receptor excision circles
D. T cell receptor emptying cycles

14 Strains of HIV that utilize CCR5 as a co-receptor are called ?
A. CCR5 viruses
B. CR5 viruses
C. R5 viruses
D. All of the above

15 Strains of HIV that utilize CXCR4 as a co-receptor are called ?
A. R4 viruses
B. CR4 viruses
C. XCR4 viruses
D. X4 viruses

16 Strains of HIV that utilize both CCR5 and CXCR4 as co-receptors
are referred to as ?
A. R5X4 viruses
B. X4R5 viruses
C. 5R4X viruses
D. R54X viruses

17 Which of the following is the transmitting strain of HIV ?
A. R5 virus
B. X4 virus
C. R5X4 virus
D. All of the above

18 In what percentage of HIV-infected individuals, there is a transition
from R5 to X4 virus ?
A. ~ 20 %
B. ~ 40 %
C. ~ 60 %
D. ~ 80 %

19 Which of the following subtypes, or clades of HIV-1 M group virus
almost never switch from CCR5 to CXCR4 tropism ?
A. A
B. B
C. C
D. D

20 The natural chemokine ligands for HIV co-receptor CCR5 are all
except ?
A. RANTES (CCL5)
B. MIP-1alpha (CCL3)
C. MIP-1beta (CCL4)
D. SDF-1

21 Natural chemokine ligands for HIV co-receptor CXCR4 is ?
A. RANTES (CCL5)
B. MIP-1alpha (CCL3)
C. MIP-1beta (CCL4)
D. SDF-1

22 Which of the following is also a co-receptors for HIV ?
A. CCR2
B. CCR3
C. GPR1
D. All of the above

23 Which of the following is the macrophage-tropic strain of HIV ?
A. R5 virus
B. X4 virus
C. R5X4 virus
D. All of the above

24 Individuals with which of the following are protected against HIV
infection ?
A. Homozygous for CCR5-32 deletion
B. Heterozygous for the CCR2-64I mutation
C. RANTES-28G mutation
D. All of the above
25 One of the first immune defects detected in HIV disease is ?
A. Defective T cell cloning & colony-forming efficiencies
B. Decreased IFN- production in response to antigens
C. Defect in response to remote recall antigens
D. Response to mitogenic stimulationn

HIV / AIDS

[MCQ] HIV / AIDS- Part 6

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HIV / AIDS- Part 6

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