[MCQ] Disorders of the Testes and Male Reproductive System- Part 6

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Disorders of the Testes and Male Reproductive System- Part 6

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Congratulations - you have completed Disorders of the Testes and Male Reproductive System- Part 6. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

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Question 1

Which of the following statements about age related hormone status is false ?

A	Testosterone levels decrease with age
B	SHBG levels are higher in older men
C	Gradual rise of LH levels with age
D	None of the above

Question 2

Which of the following diseases increase in occurrence in offspring of men who are advanced in age ?

A	Achondroplasia
B	Polyposis coli
C	Marfan syndrome
D	All of the above

Question 2 Explanation:

Incidence of autosomal dominant diseases like achondroplasia, polyposis coli, Marfan syndrome & Apert’s syndrome increases in offspring of men who are advanced in age (sporadic missense mutations

Question 3

In a patient with symptoms or signs of androgen deficiency, what level of total testosterone denotes testosterone deficiency ?

A	< 300 ng/dL
B	< 400 ng/dL
C	< 600 ng/dL
D	< 800 ng/dL

Question 4

What level of total testosterone excludes testosterone deficiency ?

A	> 50 ng/dL
B	> 150 ng/dL
C	> 250 ng/dL
D	> 350 ng/dL

Question 5

Samples for testosterone estimation are obtained in ?

A	Early-morning
B	Noon
C	Evening
D	Midnight

Question 5 Explanation:

Suspicion of androgen deficiency prompts measurement of total testosterone, preferably in morning. Total testosterone level <300 ng/dL in association with symptoms is evidence of testosterone deficiency. Early-morning testosterone level >350 ng/dL makes diagnosis of androgen deficiency unlikely

Question 6

Samples for testosterone estimation are obtained in ?

A	Early-morning
B	Noon
C	Evening
D	Midnight

Question 6 Explanation:

Question 7

Which of the following is not a cause of primary testicular failure ?

A	Klinefelter syndrome
B	HIV infection
C	Hemochromatosis
D	Prior infectious orchitis

Question 8

Which of the following is not a cause of primary testicular failure ?

A	Klinefelter syndrome
B	Cancer chemotherapeutic agents
C	Prior infectious orchitis
D	Hyperprolactinemia

Question 8 Explanation:

Common causes of primary testicular dysfunction include Klinefelter syndrome, uncorrected cryptorchidism, cancer chemotherapy, radiation to testes, trauma, torsion, infectious orchitis, HIV infection, anorchia syndrome & myotonic dystrophy

Question 9

Which of the following is not a cause of acquired hypogonadotropic hypogonadism ?

A	Space-occupying lesions of sella
B	Hyperprolactinemia
C	Hemochromatosis
D	Prior infectious orchitis

Question 10

Which of the following is not a cause of acquired hypogonadotropic hypogonadism ?

A	Chronic illness
B	Excessive exercise
C	Substance abuse
D	Uncorrected cryptorchidism

Question 10 Explanation:

Common causes of acquired secondary hypogonadism include space-occupying lesions of the sella, hyperprolactinemia, chronic illness, hemochromatosis, excessive exercise, and substance abuse

Question 11

Human menopausal gonadotropin (hMG) contains ?

A	FSH
B	LH
C	FSH & LH
D	None of the above

Question 12

Human menopausal gonadotropin (hMG) is derived from which of the following of postmenopausal women ?

A	Urine
B	Blood
C	Saliva
D	Any of the above

Question 12 Explanation:

Human menopausal gonadotropin (hMG) is purified from urine of postmenopausal women and contains FSH & LH.

Question 13

Which of the following is useful in restoring spermatogenesis ?

A	FSH
B	LH
C	hCG
D	All of the above

Question 14

When drugs are used to restore spermatogenesis, testosterone levels should be raised to ?

A	Low-normal range
B	Mid-normal range
C	High-normal range
D	Any of the above

Question 14 Explanation:

Drugs used to restore spermatogenesis should bring testosterone levels into the mid-normal range

Question 15

After 6 months of hCG alone therapy, if testosterone levels are in mid-normal range and sperm concentrations are low, which of the following should be done ?

A	Increase dose of hCG
B	Add LH
C	Add FSH
D	Any of the above

Question 15 Explanation:

FSH is available as hMG, highly purified urinary hFSH, or recombinant hFSH.

Question 16

Which of the following is a mandatory requirement of GnRH therapy ?

A	Documented GnRH deficiency
B	Normal pituitary function
C	Normal testicular function
D	All of the above

Question 16 Explanation:

In documented GnRH deficiency, both pubertal development & spermatogenesis can be successfully induced by pulsatile administration of low doses of GnRH. This response requires normal pituitary & testicular function.

Question 17

Androgen therapy can be given in all except ?

A	Bone marrow failure
B	Hereditary angioedema
C	Endometriosis
D	Sleep apnea

Question 17 Explanation:

Testosterone should not be given in prostate cancer, benign prostatic hypertrophy, to men with baseline hematocrit >=50% and sleep apnea syndrome.

Question 18

Test for assessing the adequacy of testosterone replacement is ?

A	Measurements of testosterone levels
B	Measurements of LH
C	Measurements of FSH
D	All of the above

Question 18 Explanation:

LH & FSH estimation are not useful in assessing adequacy of testosterone replacement. Testosterone should be measured 3 months after initiating therapy to assess adequacy of therapy

Question 19

Most frequent adverse event reported in testosterone trials in middle-aged and older men is ?

A	Rise in PSA levels
B	Erythrocytosis
C	Cholestasis
D	Pruritis

Question 20

Androgenic steroids used by athletes is ?

A	Nandrolone
B	Stanozolol
C	Methandienone
D	All of the above

Question 20 Explanation:

Commonly used androgenic steroids by athletes include testosterone esters, nandrolone, stanozolol, methandienone & methenolol

Question 21

In athletes, stacking refers to ?

A	Withdrawal symptoms of androgenic steroids
B	Increasing doses of single androgenic steroid
C	Increasing doses of multiple androgenic steroids
D	Rage reactions with of androgenic steroids

Question 21 Explanation:

Athletes use increasing doses of multiple steroids in a practice known as stacking.

Question 22

Muscle-building or performance-enhancing agents include ?

A	IGF-1
B	Insulin
C	Thyroxine
D	All of the above

Question 22 Explanation:

Drugs perceived to be muscle-building or performance-enhancing include growth hormone, IGF- 1, insulin, amphetamine, clenbuterol, ephedrine and thyroxine

Question 23

Method for detecting androgen abuse is ?

A	Gas chromatography-mass spectrometry
B	Liquid chromatography-mass spectrometry
C	High-resolution mass spectrometry
D	All of the above

Question 23 Explanation:

Gas chromatography-mass spectrometry, liquid chromatography-mass spectrometry, highresolution mass spectrometry and tandem mass spectrometry are of use in detecting androgen abuse.

Question 24

Illicit testosterone use is detected by measurement of ?

A	Urinary testosterone
B	Urinary epitestosterone
C	Urinary testosterone to epitestosterone ratio
D	Urinary testosterone to serum testosterone ratio

Question 24 Explanation:

Exogenous testosterone administration increases urinary testosterone glucuronide excretion & consequently testosterone to epitestosterone ratio. Ratios > 6 suggest exogenous testosterone use

Question 25

Illicit testosterone use is confirmed by measurement of ?

A	Urinary 13C : 12C ratio in testosterone
B	Urinary 11C : 12C ratio in testosterone
C	Urinary 10C : 11C ratio in testosterone
D	Urinary 9C : 10C ratio in testosterone

Question 25 Explanation:

Exogenous testosterone use is confirmed by estimating 13C : 12C ratio in testosterone by isotope ratio combustion mass spectrometry. Synthetic testosterone has a lower 13C : 12C ratio than endogenously produced testosterone

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See all quizzes of Disorders of the Testes and Male Reproductive System at here:

Disorders of the Testes and Male Reproductive System- Part 1| Disorders of the Testes and Male Reproductive System- Part 2|Disorders of the Testes and Male Reproductive System- Part 3|Disorders of the Testes and Male Reproductive System- Part 4|Disorders of the Testes and Male Reproductive System- Part 5|Disorders of the Testes and Male Reproductive System- Part 6

1.Which of the following statements about age related hormone
status is false ?
A. Testosterone levels decrease with age
B. SHBG levels are higher in older men
C. Gradual rise of LH levels with age
D. None of the above
2. Which of the following diseases increase in occurrence in offspring
of men who are advanced in age ?
A. Achondroplasia
B. Polyposis coli
C. Marfan syndrome
D. All of the above

3. In a patient with symptoms or signs of androgen deficiency, what
level of total testosterone denotes testosterone deficiency ?
A. < 300 ng/dL
B. < 400 ng/dL
C. < 600 ng/dL
D. < 800 ng/dL
4. What level of total testosterone excludes testosterone deficiency ?
A. > 50 ng/dL
B. > 150 ng/dL
C. > 250 ng/dL
D. > 350 ng/dL
5. Samples for testosterone estimation are obtained in ?
A. Early-morning
B. Noon
C. Evening
D. Midnight

6. Which of the following is not a cause of primary testicular failure ?
A. Klinefelter syndrome
B. HIV infection
C. Hemochromatosis
D. Prior infectious orchitis
7.Which of the following is not a cause of primary testicular failure
?
A. Klinefelter syndrome
B. Cancer chemotherapeutic agents
C. Prior infectious orchitis
D. Hyperprolactinemia

8. Which of the following is not a cause of acquired
hypogonadotropic hypogonadism ?
A. Space-occupying lesions of sella
B. Hyperprolactinemia
C. Hemochromatosis
D. Prior infectious orchitis
9. Which of the following is not a cause of acquired
hypogonadotropic hypogonadism ?
A. Chronic illness
B. Excessive exercise
C. Substance abuse
D. Uncorrected cryptorchidism

10. Human menopausal gonadotropin (hMG) contains ?
A. FSH
B. LH
C. FSH & LH
D. None of the above

11. Human menopausal gonadotropin (hMG) is derived from which
of the following of postmenopausal women ?
A. Urine
B. Blood
C. Saliva
D. Any of the above

12. Which of the following is useful in restoring spermatogenesis ?
A. FSH
B. LH
C. hCG
D. All of the above
13. When drugs are used to restore spermatogenesis, testosterone
levels should be raised to ?
A. Low-normal range
B. Mid-normal range
C. High-normal range
D. Any of the above

14. After 6 months of hCG alone therapy, if testosterone levels are in
mid-normal range and sperm concentrations are low, which of
the following should be done ?
A. Increase dose of hCG
B. Add LH
C. Add FSH
D. Any of the above

15. Which of the following is a mandatory requirement of GnRH
therapy ?
A. Documented GnRH deficiency
B. Normal pituitary function
C. Normal testicular function
D. All of the above

16. Androgen therapy can be given in all except ?
A. Bone marrow failure
B. Hereditary angioedema
C. Endometriosis
D. Sleep apnea

17. Test for assessing the adequacy of testosterone replacement is ?
A. Measurements of testosterone levels
B. Measurements of LH
C. Measurements of FSH
D. All of the above

18. Most frequent adverse event reported in testosterone trials in
middle-aged and older men is ?
A. Rise in PSA levels
B. Erythrocytosis
C. Cholestasis
D. Pruritis

19. Androgenic steroids used by athletes is ?
A. Nandrolone
B. Stanozolol
C. Methandienone
D. All of the above

20. In athletes, stacking refers to ?
A. Withdrawal symptoms of androgenic steroids
B. Increasing doses of single androgenic steroid
C. Increasing doses of multiple androgenic steroids
D. Rage reactions with of androgenic steroids

21. Muscle-building or performance-enhancing agents include ?
A. IGF-1
B. Insulin
C. Thyroxine
D. All of the above

22. Method for detecting androgen abuse is ?
A. Gas chromatography-mass spectrometry
B. Liquid chromatography-mass spectrometry
C. High-resolution mass spectrometry
D. All of the above

23. Illicit testosterone use is detected by measurement of ?
A. Urinary testosterone
B. Urinary epitestosterone
C. Urinary testosterone to epitestosterone ratio
D. Urinary testosterone to serum testosterone ratio

24. Illicit testosterone use is confirmed by measurement of ?
A. Urinary 13C : 12C ratio in testosterone
B. Urinary 11C : 12C ratio in testosterone
C. Urinary 10C : 11C ratio in testosterone
D. Urinary 9C : 10C ratio in testosterone

Disorders of the Testes and Male Reproductive System

[MCQ] Disorders of the Testes and Male Reproductive System- Part 6

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Disorders of the Testes and Male Reproductive System- Part 6

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