[MCQ] Disorders of the Testes and Male Reproductive System- Part 1

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Disorders of the Testes and Male Reproductive System- Part 1

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Question 1

Testosterone is produced by ?

A	Leydig cells
B	Sertoli cells
C	Interstitial cells
D	All of the above

Question 1 Explanation:

Leydig cells of the testes produce testosterone and germ cells are nurtured by Sertoli cells to divide, differentiate, and mature into sperm.

Question 2

Testicular descent through inguinal canal is controlled by ?

A	Insulin-like factor 1 (INSL1)
B	Insulin-like factor 2 (INSL2)
C	Insulin-like factor 3 (INSL3)
D	Insulin-like factor 4 (INSL4)

Question 3

Insulin-like factor 3 (INSL3) is produced by ?

A	Leydig cells
B	Sertoli cells
C	Interstitial cells
D	All of the above

Question 4

Insulin-like factor 3 (INSL3) acts via receptor termed ?

A	Great
B	Gap
C	Ghost
D	Good

Question 4 Explanation:

Testicular descent through inguinal canal is controlled by Leydig cell production of insulin-like factor 3 (INSL3), which acts via a receptor termed Great (G protein–coupled receptor affecting testis descent).

Question 5

Mullerian inhibiting substance (MIS) is produced by ?

A	Leydig cells
B	Sertoli cells
C	Interstitial cells
D	All of the above

Question 5 Explanation:

Sertoli cells produce müllerian inhibiting substance (MIS) which regresses müllerian structures (fallopian tube, uterus & upper segment of vagina).

Question 6

“SRY” stands for ?

A	Sex-regulating gene on the Y chromosome
B	Sex-related gene on the Y chromosome
C	Sex-restricting gene on the Y chromosome
D	Sex-requiring gene on the Y chromosome

Question 6 Explanation:

SRY stands for sex-related gene on the Y chromosome.

Question 7

Formation of prostate & external male genitalia is induced by ?

A	Testosterone
B	Dihydrotestosterone (DHT)
C	FSH
D	LH

Question 7 Explanation:

Conversion of testosterone to DHT leads to growth of external genitalia & pubic hair. DHT also stimulates prostate & facial hair growth & initiates recession of temporal hairline.

Question 8

Growth & differentiation of Wolffian duct structures is induced by ?

A	Testosterone
B	DHT
C	FSH
D	LH

Question 8 Explanation:

During embryonic development, testosterone and dihydrotestosterone (DHT) induce the wolffian duct and virilization of the external genitalia. During puberty, testosterone promotes somatic growth and the development of secondary sex characteristics. In the adult, testosterone is necessary for spermatogenesis and stimulation of libido & normal sexual function.

Question 9

In males, adrenarche usually occurs between age ?

A	6 and 8 years
B	8 and 10 years
C	10 and 12 years
D	12 and 14 years

Question 9 Explanation:

Adrenarche usually occurs between 6 - 8 years of age when adrenal gland begins to produce more of androgens from zona reticularis, the principal site of dehydroepiandrosterone (DHEA) production.

Question 10

In males sexual maturation process is dependent on ?

A	Dehydroepiandrosterone (DHEA)
B	Gonadotropin-releasing hormone (GnRH)
C	Leptin
D	All of the above

Question 10 Explanation:

DHEA from adrenal gland induces adrenarche. Gonadotropin-releasing hormone (GnRH) secretion from hypothalamus induces puberty through GPR54, a G protein–coupled receptor binds an endogenous ligand, metastin. Leptin hormone from adipose cells plays a permissive role in the onset of puberty

Question 11

In males, growth spurt occurs at a testicular volume of ?

A	4 to 6 mL
B	6 to 10 mL
C	10 to 12 mL
D	15 to 20 mL

Question 11 Explanation:

Growth spurt occurs at a testicular volume of about 10 - 12 mL.

Question 12

Hypothalamic GnRH is released in discrete pulses approximately every ?

A	1 hours
B	2 hours
C	3 hours
D	4 hours

Question 13

In normal men, LH pulses occur about every ?

A	Half - 1 hour
B	1 - 3 hours
C	3 - 4 hours
D	4 - 6 hours

Question 13 Explanation:

GnRH is released in discrete pulses ~ every 2 hours, resulting in corresponding pulses of LH & FSH. LH pulses occur about every 1 - 3 hours in normal men. FSH is less pulsatile than LH because it has a longer half-life.

Question 14

Which of the following statements is false ?

A	LH acts on Leydig cells
B	FSH acts on Sertoli cells
C	Inhibin B is produced by Sertoli cells
D	None of the above

Question 14 Explanation:

LH acts on Leydig cell to stimulate testosterone synthesis. FSH acts on Sertoli cell to regulate spermatogenesis & production of inhibin B, which acts to selectively suppress pituitary FSH.

Question 15

“StAR” stands for ?

A	Steroid active regulatory protein
B	Steroid associated regulatory protein
C	Steroid acute regulatory protein
D	Steroid amplifying regulatory protein

Question 15 Explanation:

StAR stands for steroid acute regulatory protein.

Question 16

The number of carbon atoms in a cholesterol molecule is ?

A	25
B	26
C	27
D	28

Question 16 Explanation:

Cholesterol is a 27-carbon molecule.

Question 17

In testosterone synthesis from cholesterol, how many major enzymatic steps are involved ?

A	2
B	3
C	4
D	5

Question 17 Explanation:

five major enzymatic steps involved in testosterone synthesis.

Question 18

Which of the following is converted by 17-HSD3 to testosterone ?

A	Pregnenolone
B	Progesterone
C	Androstenedione
D	17-OH-Progesterone

Question 19

Testosterone is converted to dihydrotestosterone (DHT) by ?

A	5α-reductase
B	17α-Hydroxylase
C	17β-Hydroxysteroid dehydrogenase 2
D	17β-Hydroxysteroid dehydrogenase 3

Question 20

Pregnenolone is formed from cholesterol through cleavage by ?

A	CYP17
B	CYP11A1
C	CYP19
D	17β-Hydroxysteroid dehydrogenase 2

Question 21

Which of the following acts as a catalyst ?

A	CYP17
B	CYP11A1
C	CYP19
D	17β-Hydroxysteroid dehydrogenase 2

Question 21 Explanation:

17-hydroxylase & 17,20-lyase reactions are catalyzed by CYP17.

Question 22

Daily testicular secretion of circulating testosterone is ?

A	3 to 10 mg/day
B	8 to 20 mg/day
C	13 to 30 mg/day
D	20 to 40 mg/day

Question 22 Explanation:

In males, 95% of circulating testosterone is derived from testicular production which is 3 - 10 mg/day.

Question 23

Which of the following statements is false ?

A	Most circulating DHT comes from peripheral conversion of testosterone
B	A small amount of DHT is secreted directly by testis
C	In men, daily production of estradiol comes from peripheral conversion of testosterone & androstenedione
D	None of the above

Question 24

What proportion of testosterone is “unbound” ?

A	0.5 to 3 %
B	5 to 8 %
C	11 to 13 %
D	15 to 30 %

Question 24 Explanation:

Only 0.5 - 3% of circulating testosterone is not bound to sex hormone binding globulin (SHBG) & albumin.

Question 25

Sex hormone binding globulin (SHBG) concentrations are decreased by all except ?

A	Androgens
B	Obesity
C	Hyperthyroidism
D	Nephrotic syndrome

Question 26

Sex hormone binding globulin (SHBG) concentrations are decreased by all except ?

A	Androgens
B	Estrogen
C	Insulin
D	Nephrotic syndrome

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See all quizzes of Disorders of the Testes and Male Reproductive System at here:

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1. Testosterone is produced by ?
A. Leydig cells
B. Sertoli cells
C. Interstitial cells
D. All of the above

2. Testicular descent through inguinal canal is controlled by ?
A. Insulin-like factor 1 (INSL1)
B. Insulin-like factor 2 (INSL2)
C. Insulin-like factor 3 (INSL3)
D. Insulin-like factor 4 (INSL4)
3. Insulin-like factor 3 (INSL3) is produced by ?
A. Leydig cells
B. Sertoli cells
C. Interstitial cells
D. All of the above
4. Insulin-like factor 3 (INSL3) acts via receptor termed ?
A. Great
B. Gap
C. Ghost
D. Good

5. Mullerian inhibiting substance (MIS) is produced by ?
A. Leydig cells
B. Sertoli cells
C. Interstitial cells
D. All of the above

6. “SRY” stands for ?
A. Sex-regulating gene on the Y chromosome
B. Sex-related gene on the Y chromosome
C. Sex-restricting gene on the Y chromosome
D. Sex-requiring gene on the Y chromosome
SRY stands for sex-related gene on the Y chromosome.
7. Formation of prostate & external male genitalia is induced by ?
A. Testosterone
B. Dihydrotestosterone (DHT)
C. FSH
D. LH

8. Growth & differentiation of Wolffian duct structures is induced
by ?
A. Testosterone
B. DHT
C. FSH
D. LH

9. In males, adrenarche usually occurs between age ?
A. 6 and 8 years
B. 8 and 10 years
C. 10 and 12 years
D. 12 and 14 years

10. In males sexual maturation process is dependent on ?
A. Dehydroepiandrosterone (DHEA)
B. Gonadotropin-releasing hormone (GnRH)
C. Leptin
D. All of the above

11. In males, growth spurt occurs at a testicular volume of ?
A. 4 to 6 mL
B. 6 to 10 mL
C. 10 to 12 mL
D. 15 to 20 mL

12. Hypothalamic GnRH is released in discrete pulses approximately
every ?
A. 1 hours
B. 2 hours
C. 3 hours
D. 4 hours
13. In normal men, LH pulses occur about every ?
A. Half – 1 hour
B. 1 – 3 hours
C. 3 – 4 hours
D. 4 – 6 hours

14. Which of the following statements is false ?
A. LH acts on Leydig cells
B. FSH acts on Sertoli cells
C. Inhibin B is produced by Sertoli cells
D. None of the above

15.“StAR” stands for ?
A. Steroid active regulatory protein
B. Steroid associated regulatory protein
C. Steroid acute regulatory protein
D. Steroid amplifying regulatory protein

16. The number of carbon atoms in a cholesterol molecule is ?
A. 25
B. 26
C. 27
D. 28

17. In testosterone synthesis from cholesterol, how many major
enzymatic steps are involved ?
A. 2
B. 3
C. 4
D. 5

18. Which of the following is converted by 17-HSD3 to
testosterone ?
A. Pregnenolone
B. Progesterone
C. Androstenedione
D. 17-OH-Progesterone
19. Testosterone is converted to dihydrotestosterone (DHT) by ?
A. 5-reductase
B. 17-Hydroxylase
C. 17-Hydroxysteroid dehydrogenase 2
D. 17-Hydroxysteroid dehydrogenase 3
20. Pregnenolone is formed from cholesterol through cleavage by ?
A. CYP17
B. CYP11A1
C. CYP19
D. 17-Hydroxysteroid dehydrogenase 2
21. Which of the following acts as a catalyst ?
A. CYP17
B. CYP11A1
C. CYP19
D. 17-Hydroxysteroid dehydrogenase 2 17-hydroxylase & 17,20-lyase reactions are catalyzed by CYP17.
22. Daily testicular secretion of circulating testosterone is ?
A. 3 to 10 mg/day
B. 8 to 20 mg/day
C. 13 to 30 mg/day
D. 20 to 40 mg/day

23. Which of the following statements is false ?
A. Most circulating DHT comes from peripheral conversion of
testosterone
B. A small amount of DHT is secreted directly by testis
C. In men, daily production of estradiol comes from peripheral
conversion of testosterone & androstenedione
D. None of the above
24.What proportion of testosterone is “unbound” ?
A. 0.5 to 3 %
B. 5 to 8 %
C. 11 to 13 %
D. 15 to 30 %

25. Sex hormone binding globulin (SHBG) concentrations are
decreased by all except ?
A. Androgens
B. Obesity
C. Hyperthyroidism
D. Nephrotic syndrome
26. Sex hormone binding globulin (SHBG) concentrations are
decreased by all except ?
A. Androgens
B. Estrogen
C. Insulin
D. Nephrotic syndrome

Disorders of the Testes and Male Reproductive System

[MCQ] Disorders of the Testes and Male Reproductive System- Part 1

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Disorders of the Testes and Male Reproductive System- Part 1

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