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Diabetes Mellitus- Part 3
See all quizzes of Diabetes Mellitus at here:
Diabetes Mellitus- Part 1|Diabetes Mellitus- Part 2|Diabetes Mellitus- Part 3|Diabetes Mellitus- Part 4|Diabetes Mellitus- Part 5|Diabetes Mellitus- Part 6|Diabetes Mellitus- Part 7
1.Presence of which haplotype in one individual confers the highest
known genetic risk for type 1 diabetes mellitus ?
A. DR3
B. DR4
C. Both DR3 & DR4
D. None of the above
2. DQB1*0302 gene is associated with which haplotype ?
A. DR3
B. DR4
C. Both DR3 & DR4
D. None of the above
3. Which of the following gene is considered “protective” for type
1A diabetes mellitus ?
A. DQB1*0302
B. DQB1*0402
C. DQB1*0502
D. DQB1*0602
4. Molecular mimicry between microbial proteins & host tissues has
been reported in ?
A. Type 1 diabetes mellitus
B. Rheumatoid arthritis
C. Multiple sclerosis
D. All of the above
5. In type 2 DM, which of the following is true ?
A. Insulin resistance precedes insulin secretory defects
B. Insulin secretory defects precede insulin resistance
C. Insulin resistance occur simultaneously with insulin secretory
defects
D. Any of the above
6. Concordance of type 2 DM in identical twins is between ?
A. 10 – 30 %
B. 30 – 50 %
C. 50 – 70 %
D. 70 – 90 %
7. If both parents have type 2 DM, risk of developing diabetes is ?
A. ~ 10 %
B. ~ 20 %
C. ~ 30 %
D. ~ 40 %
8. Adipocytes secrete which of the following ?
A. Leptin
B. Resistin
C. Adiponectin
D. All of the above
7. In type 2 DM, increased fasting plasma glucose is predominantly
due to ?
A. Increased hepatic glucose output
B. Decreased peripheral utilization of glucose
C. Both of the above
D. None of the above
8. In type 2 DM, increased postprandial plasma glucose is
predominantly due to ?
A. Increased hepatic glucose output
B. Decreased peripheral utilization of glucose
C. Both of the above
D. None of the above
9. Which of the following play predominant role in insulin
resistance ?
A. Prereceptor defects
B. Receptor defects
C.` Postreceptor defects
D. All of the above
10. Elevated levels of free fatty acids can cause which of the following
?
A. Impair glucose utilization in skeletal muscle
B. Promote glucose production by liver
C. Impair beta cell function
D. All of the above
11. Other than insulin, cells also secrete ?
A. Ptyalin
B. Amylin
C. Amylase
D. Lipase
12. “Glucose toxicity” refers to ?
A. Acute hyperglycemia impairing islet function
B. Chronic hyperglycemia impairing islet function
C. Seizures in hyperglycemia
D. All of the above
13. All can cause islet cell dysfunction except ?
A. Hyperglycemia
B. Hypoglycemia
C. Hyperlipidemia
D. Islet cell autoantibodies
14. Which of the following can worsen islet function ?
A. Chronic hyperglycemia
B. Elevation of free fatty acid levels
C. Dietary fat
D. All of the above
15. Which of the following is a feature of Polycystic ovary syndrome
(PCOS) ?
A. Affects premenopausal women
B. Chronic anovulation
C. Hyperandrogenism
D. All of the above
16. All are proved to delay or prevent DM except ?
A. Life style modification
B. Metformin
C. Ramipril
D. Atorvastatin
17. All are proved to delay or prevent DM except ?
A. Acarbose
B. Metformin
C. NSAIDs
D. Pravastatin
18. All are risk factors for type 2 DM except ?
A. Hypertension
B. Acanthosis nigricans
C. PCOD
D. Ataxia telangiectasia
19. All of the following are true about MODY except ?
A. Monogenic
B. Autosomal dominant
C. MODY 4 is due to mutation in IPF-1
D. MODY 1 is due to mutation in glucokinase gene
20. Hepatocyte nuclear transcription factor (HNF) is expressed in ?
A. Liver
B. Pancreatic islets
C. Kidney
D. All of the above
21. MODY 1 is caused by mutations in ?
A. HNF-4 alpha
B. HNF-1 alpha
C. HNF-1 beta
D. All of the above
22. Cerebral edema in DKA is seen most frequently in ?
A. Children
B. Adults
C. Elderly
D. All of the above
23. In liver, decreased ratio of insulin to glucagon promotes which of
the following ?
A. Gluconeogenesis
B. Glycogenolysis
C. Ketone body formation
D. All of the above
