[MCQ] Diabetes Mellitus- Part 1

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1.Most recent classification of diabetes mellitus is based on ?
A. Pathogenic process leading to hyperglycemia
B. Age of onset
C. Type of therapy
D. All of the above

2. Type of diabetes mellitus resulting from autoimmune beta cell
destruction is ?
A. Type IA
B. Type IB
C. Type II
D. All of the above

3. Type 2 diabetes mellitus is characterized by all except ?
A. Insulin resistance
B. Impaired insulin secretion
C. Increased glucose production
D. Anti-insulin receptor antibodies

4. Maturity onset diabetes of the young (MODY) is characterized by
all except ?
A. Autosomal dominant inheritance
B. Autosomal recessive inheritance
C. Early onset hyperglycemia
D. Impairment of insulin secretion

5. All of the following viruses can cause DM except ?
A. Congenital Rubella
B. CMV
C. EBV
D. Coxsackie

6. All of the following drugs can cause DM except ?
A. Diazoxide
B. Pyrantel pamoate
C. Pentamidine
D. Phenytoin
7. Drugs that can cause DM include ?
A. Nicotinic acid
B. Thyroid hormone
C. Beta-adrenergic agonists
D. All of the above
8. Drugs that can cause DM include ?
A. Thiazides
B. Phenytoin
C. Beta blockers
D. All of the above
9. Drugs that can cause DM include ?
A. Alpha-interferon
B. Protease inhibitors
C. Clozapine
D. All of the above

10. Syndromes associated with DM are all except ?
A. Down syndrome
B. Klinefelter syndrome
C. Turner syndrome
D. Cri-du-chat syndrome

11. Out of the following countries, which one has the highest incidence
of type 1 DM ?
A. Japan
B. China
C. Scandinavia

12. In the ADA criteria for diagnosis of DM, what is meant by “fasting
state” ?
A. No oral intake since last 8 hours
B. No oral intake for last 12 hours
C. No caloric intake for last 8 hours
D. No caloric intake for last 12 hours

13. After 2 hours of 75-gram oral glucose load, impaired glucose
tolerance is defined when plasma glucose levels are between ?
A. 100 & 180 mg/dL
B. 126 & 180 mg/dL
C. 140 & 199 mg/dL
D. 160 & 200 mg/dL

15. After 2 hours of 75-gram oral glucose load, impaired fasting
glucose is defined when fasting plasma glucose level are between
?
A. 80 & 125 mg/dL
B. 100 & 125 mg/dL
C. 125 & 180 mg/dL
D. 125 & 200 mg/dL

16. Individuals with impaired fasting glucose are at increased risk of
developing which of the following condition ?
A. Neuropathy
B. Arthropathy
C. Cardiovascular diseases
D. Renal failure
17. Individuals with impaired fasting glucose (IFG) are at increased
risk of developing ?
A. Type 1 DM
B. Type 2 DM
C. Pancreatitis
D. Hypothyroidism

18. American Diabetes Association (ADA) recommends screening for
DM in which of the following ?
A. >35 yrs – every three years
B. >40 yrs – every three years
C. >45 yrs – every three years
D. >50 yrs – every year

19. 86-amino-acid precursor polypeptide of insulin is called ?
A. C-peptide
B. Preinsulin
C. Proinsulin
D. Preproinsulin

20. Proteolytic processing of “preproinsulin” results in the formation
of ?
A. C peptide
B. Proinsulin
C. Insulin
D. All of the above

21. Which of the following is structurally related to insulin-like growth
factors I and II ?
A. Preproinsulin
B. Proinsulin
C. Insulin
D. Glucagon

22. Cleavage of proinsulin generates which of the following ?
A. C peptide
B. A chain of insulin
C. B chain of insulin
D. All of the above

23. The A and B chains of insulin contain how many amino acids
respectively ?
A. 21 & 30 amino acids
B. 30 & 21 amino acids
C. 21 & 29 amino acids
D. 29 & 21 amino acids
24. The A and B chains of insulin are connected by which of the
following bond ?
A. Hydrogen
B. Amino acid
C. Disulfide
D. Calcium

25. Insulin synthesis is stimulated by glucose levels above ?
A. 30 mg%
B. 40 mg%
C. 50 mg%
D. 70 mg%

26. Word insulin is derived from a Latin word “insula” meaning ?
A. Protected
B. Projected
C. Island
D. High land