[Immunology] The Hypersensitivity Quizzes (14 tests)

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[Immunology] The Hypersensitivity Quizzes (14 tests)
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Select the one best response to each question!

Which of the following is a general characteristic of hypersensitivity reactions?


1. Which of the following is a general characteristic of hypersensitivity reactions?
a. Immune responsiveness is depressed.
b. Antibody is involved in all reactions.
c. Either self-antigen or heterologous antigen may be involved.
d. The antigen triggering the reaction is a harmful one.
2. Which of the following is associated with an increase in IgE production?
a. Transfusion reaction
b. Activation of Th1 cells
c. Reaction to poison ivy
d. HDN
3. Which of the following would cause a positive DAT test?
a. Presence of IgG on red cells
b. Presence of C3b or C3d on red cells
c. A transfusion reaction due to preformed antibody
d. Any of the above
4. All of the following are associated with type I hypersensitivity except
a. release of preformed mediators from mast cells.
b. activation of complement.
c. cell-bound antibody bridged by antigen.
d. an inherited tendency to respond to allergens.
5. Which newly synthesized mediator has a mode of actio similar to that of histamine?
a. LTB4
b. Heparin
c. ECF-A
d. PGD2
6. Which of the following is associated with anaphylaxis?
a. Buildup of IgE on mast cells
b. Activation of complement
c. Increase in cytotoxic T cells
d. Large amount of circulating IgG
7. To determine if a patient is allergic to rye grass, the best test to perform is
a. total IgE testing.
b. skin prick test.
c. DAT.
d. complement fixation.
8. Which condition would result in HDN?
a. Buildup of IgE on mother’s cells
b. Sensitization of cytotoxic T cells
c. Exposure to antigen found on both mother and baby red cells
d. Prior exposure to foreign red cell antigen
9. What is the immune mechanism involved in type III hypersensitivity reactions?
a. Cellular antigens are involved.
b. Deposition of immune complexes occurs in antibody excess.
c. Only heterologous antigens are involved.
d. Tissue damage results from exocytosis.
10. What is the immune phenomenon associated with the Arthus reaction?
a. Tissue destruction by cytotoxic T cells
b. Removal of antibody-coated red blood cells
c. Deposition of immune complexes in blood vessels
d. Release of histamine from mast cells
11. Contact dermatitis can be characterized by all of the following except
a. formation of antigen–antibody complexes.
b. generation of sensitized T cells.
c. Langerhans cells acting as antigen-presenting cells.
d. complexing of a hapten to self-antigen.
12. Which of the following conclusions can be drawn about a patient whose total IgE level is determined to be 150 IU/mL?
a. The patient definitely has allergic tendencies.
b. The patient may be subject to anaphylactic shock.
c. Further antigen-specific testing should be done.
d. The patient will never have an allergic reaction.
13. Which of the following explains the difference between type II and type III hypersensitivity reactions?
a. Type II involves cellular antigens.
b. Type III involves IgE.
c. IgG is involved only in type III reactions.
d. Type II reactions involve no antibody
14. A 37-year-old woman received two units of packed red blood cells following a surgical procedure. She had been transfused once before. Five days after surgery, she experienced a slight fever and some hemoglobin in her urine, indicating a delayed transfusion reaction. A DAT test on a blood sample was positive. Which of the following statements best describes this reaction?
a. The patient had IgM antibody to the red cells transfused.
b. The patient’s reaction was due to an amnestic response.
c. Only IgE was coating the transfused red blood cells.
d. The antibody present reacted best at room temperature.

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