[Immunology] The Agglutination Quizzes (12 tests)

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[Immunology] The Agglutination Quizzes (12 tests)
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Select the one best response to each question!

Which of the following best describes agglutination?


1. Which of the following best describes agglutination?
a. A combination of soluble antigen with soluble antibody
b. A combination of particulate antigen with soluble antibody
c. A reaction that produces no visible end point
d. A reaction that requires instrumentation to read
2. All of the following could be used to enhance an agglutination reaction except
a. increasing the viscosity of the medium.
b. using albumin.
c. increasing the ionic strength of the medium.
d. centrifugation.
3. Agglutination of dyed bacterial cells represents which type of reaction?
a. Direct agglutination
b. Passive agglutination
c. Reverse passive agglutination
d. Agglutination inhibition
4. In which of the following circumstances would the indirect Coombs’ test be employed?
a. Identification of the ABO blood groups
b. Identification of cold-reacting antibody
c. Identification of an unexpected IgG antibody
d. Identification of hemolytic disease of the newborn
5. In an agglutination reaction, if cells are not centrifuged long enough, which of the following might occur?
a. False-negative result
b. False-positive result
c. No effect
d. Slight effect but can be ignored
6. Agglutination inhibition could best be used for which of the following types of antigens?
a. Large cellular antigens such as erythrocytes
b. Soluble haptens
c. Bacterial cells
d. Antigen attached to latex particles
7. Which of the following correctly describes reverse passive agglutination?
a. It is a negative test.
b. It can be used to detect autoantibodies.
c. It is used for identification of bacterial antigens.
d. It is used to detect sensitization of red blood cells.
8. In which of the following tests is patient antigen determined by measuring the number of nonagglutinating particles left after the reaction has taken place?
a. Direct agglutination
b. Coagglutination
d. Coombs’ testing
9. Reactions involving IgG may need to be enhanced for which reason?
a. It is only active at 25°C.
b. It may be too small to produce lattice formation.
c. It has only one antigen-binding site.
d. It is not able to produce visible in vitro agglutination.
10. For which of the following tests is a lack of agglutination a positive reaction?
a. Hemagglutination
b. Passive agglutination
c. Reverse passive agglutination
d. Agglutination inhibition
11. All of the following would be considered good qualitycontrol procedures except
a. storing reagents properly.
b. standardizing temperature of reactions.
c. allowing the reaction to go as long as possible.
d. using monoclonal antibody to avoid cross-reactivity.
12. A positive direct Coombs’ test could occur under which circumstances?
a. Hemolytic disease of the newborn
b. Autoimmune hemolytic anemia
c. Antibodies to drugs that bind to red cells
d. Any of the above

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