[MCQ] Acute and Chronic Pancreatitis- Part 1

I. Start the exam by click the “Start” button

Acute and Chronic Pancreatitis- Part 1

Please wait while the activity loads.
If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled.

If loading fails, click here to try again

Start

Congratulations - you have completed Acute and Chronic Pancreatitis- Part 1. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

Your answers are highlighted below.

Question 1

The quantity of pancreatic secretion per day is ?

A	1000 - 1500 ml
B	1500 - 3000 ml
C	3000 - 4500 ml
D	About 5000 ml

Question 2

The pancreatic secretion contain about ?

A	10 enzymes and zymogens
B	20 enzymes and zymogens
C	30 enzymes and zymogens
D	40 enzymes and zymogens

Question 3

The pancreatic secretion is ?

A	Isosmotic alkaline
B	Isosmotic acidic
C	Hyposmotic alkaline
D	Hyposmotic acidic

Question 3 Explanation:

Pancreas secretes 1500 - 3000 mL of isosmotic alkaline (pH > 8.0) fluid / day containing ~20 enzymes & zymogens.

Question 4

Which of the following about secretin is false ?

A	Gastric acid is a stimulus for release of secretin
B	Secretin is a peptide with 27 amino acids
C	pH threshold for release of secretin from duodenum & jejunum is 6.5
D	Secretin stimulates secretion of pancreatic juice rich in water & electrolytes

Question 5

Which of the following about cholecystokinin (CCK) is false ?

A	CCK evokes an enzyme-rich secretion from pancreas
B	Release of CCK is triggered by short-chain fatty acids
C	Release of CCK is triggered by essential amino acids
D	Release of CCK is triggered by gastric acid

Question 5 Explanation:

Release of CCK from duodenum & jejunum is triggered by long-chain fatty acids, essential amino acids (tryptophan, phenylalanine, valine, methionine), and gastric acid itself.

Question 6

Which of the following statements is false ?

A	Bile salts stimulate pancreatic secretion
B	Parasympathetic nervous system exerts significant control over pancreatic secretion
C	Vasoactive intestinal peptide (VIP) is a CCK agonist
D	H2O and HCO3- secretion by pancreas is dependent secretin and CCK

Question 6 Explanation:

Vagal stimulation leads to release of VIP which is a secretin agonist.

Question 7

The quantity of bicarbonate from pancreas needed to neutralize gastric acid is ?

A	20 to 30 mmol/day
B	50 to 100 mmol/day
C	120 to 300 mmol/day
D	About 500 mmol/day

Question 8

In acini and in ducts, which hormone causes the cells to add water and bicarbonate to pancreatic fluid ?

A	Insulin
B	Secretin
C	Somatostatin
D	Gastrin

Question 8 Explanation:

Gastric acid is the stimulus for release of secretin which stimulates secretion of pancreatic juice rich in water and electrolytes. CCK evokes an enzyme-rich secretion from the pancreas

Question 9

Pancreatic exocrine secretion is influenced by ?

A	Somatostatin
B	Neuropeptide Y
C	Calcitonin gene - related peptides
D	All of the above

Question 9 Explanation:

Pancreatic exocrine secretion is influenced by inhibitory neuropeptides like somatostatin, pancreatic polypeptide, peptide YY, neuropeptide Y, enkephalin, pancreastatin, calcitonin gene–related peptides, glucagon, and galanin.

Question 10

Which of the following correlates best between stimulation with secretin and the pancreatic mass ?

A	Maximal sodium output
B	Maximal chloride output
C	Maximal acid output
D	Maximal bicarbonate output

Question 11

Bicarbonate in pancreatic secretion is related to ?

A	Insulin
B	Glucagon
C	Cystic fibrosis transmembrane conductance regulator
D	All of the above

Question 11 Explanation:

In pancreatic ductal cells, cystic fibrosis transmembrane conductance regulator (CFTR) controls chloride and bicarbonate fluxes.

Question 12

Pancreas secretes which of the following enzymes ?

A	Amylolytic
B	Lipolytic
C	Proteolytic
D	All of the above

Question 12 Explanation:

The pancreas secretes amylolytic, lipolytic, and proteolytic enzymes.

Question 13

The lipolytic enzymes secreted by pancreas are ?

A	Lipase
B	Phospholipase A
C	Cholesterol esterase
D	All of the above

Question 13 Explanation:

Lipolytic enzymes secreted by pancreas include lipase, phospholipase A & cholesterol esterase.

Question 14

Which of the following about bile salts is false ?

A	Inhibit lipase in isolation
B	Colipase binds to lipase & prevents inhibition by bile salts
C	Activate phospholipase A and cholesterol esterase
D	None of the above

Question 14 Explanation:

Bile salts inhibit lipase in isolation, but colipase of pancreatic secretion, binds to lipase and prevents this inhibition. Bile salts activate phospholipase A and cholesterol esterase.

Question 15

Which of the following statements is false ?

A	Bile salts inhibit lipase
B	Colipase binds to lipase
C	Bile salts activate phospholipase A & cholesterol esterase
D	None of the above

Question 15 Explanation:

Bile salts inhibit lipase. Colipase in pancreatic secretion binds to lipase and prevents this inhibition. Bile salts activate phospholipase A and cholesterol esterase.

Question 16

Proteolytic enzymes secreted as inactive precursors are called ?

A	Zymogens
B	Proteogens
C	Amylogens
D	Chymogens

Question 16 Explanation:

Proteolytic enzymes are secreted as inactive precursors called zymogens.

Question 17

Enzyme that cleaves lysine-isoleucine bond of trypsinogen to form trypsin is ?

A	Duodenokinase
B	Enterokinase
C	Gastrokinase
D	Trypsokinase

Question 18

Bond that is cleaved to form trypsin from trypsinogen is ?

A	Lysine-isoleucine bond
B	Arginine-Threonine bond
C	Arginine-Lysine bond
D	Threonine-Lysine bond

Question 19

Enzyme enterokinase is found in ?

A	Gastric mucosa
B	Duodenal mucosa
C	Jejunal mucosa
D	Ileal mucosa

Question 19 Explanation:

Enterokinase is an enzyme found in duodenal mucosa. It cleaves lysine-isoleucine bond of trypsinogen to form trypsin.

Question 20

Which of the following can lyse and inactivate trypsin ?

A	Mesotrypsin
B	Chymotrypsin c
C	Enzyme y
D	All of the above

Question 20 Explanation:

Mesotrypsin, chymotrypsin c, and enzyme y can also lyse and inactivate trypsin.

Question 21

Protease inhibitors are found in ?

A	Pancreatic acinar cells
B	Pancreatic secretions
C	Alpha1- and alpha2-globulin fractions of plasma
D	All of the above

Question 21 Explanation:

Protease inhibitors, that prevent autodigestion of pancreas, are found in the acinar cells, the pancreatic secretions, and the alpha1- and alpha2-globulin fractions of plasma.

Question 22

Kazal type 1 (SPINK1) is best related to ?

A	Pancreatic hyperstimulation
B	Alcohol abuse
C	Anti-inflammatory cytokine
D	Serine protease inhibitor

Question 22 Explanation:

Autodigestion of the pancreas is prevented by the packaging of proteases in precursor form and by the synthesis of protease inhibitors, i.e., pancreatic secretory trypsin inhibitor (PSTI) and serine protease inhibitor, kazal type 1 (SPINK1) that prevents conversion of trypsinogen to trypsin

Question 23

SPINK1 is synthesised in ?

A	Gall bladder
B	Duodenum
C	Stomach
D	Pancreas

Question 23 Explanation:

Pancreas synthesises SPINK1, a specific trypsin inhibitor, the function of which can be lost by mutation. In pancreatic ductal cells, CFTR controls chloride and bicarbonate fluxes. SPINK1 and CFTR mutations together may cause pancreatitis.

Question 24

Which of the following is not a type of trypsinogen in human pancreatic juice ?

A	Telotrypsinogen
B	Cationic trypsinogen
C	Anionic trypsinogen
D	Mesotrypsinogen

Question 24 Explanation:

Three different trypsinogens in human pancreatic juice have been designated according to their electrophoretic mobility, as cationic trypsinogen (PRSS1), anionic trypsinogen (PRSS2) & mesotrypsinogen (PRSS3). Compared with the anionic isoenzyme, cationic trypsinogen autoactivates more easily and is more resistant to autolysis.

Question 25

Which of the following is the most common PRSS1 mutation ?

A	R122A
B	R122C
C	R122H
D	R122K

Question 25 Explanation:

R122H is the most common PRSS1 mutation observed worldwide. Mutations in PRSS1 gene are seen in most patients with hereditary pancreatitis

Once you are finished, click the button below. Any items you have not completed will be marked incorrect. Get Results

There are 25 questions to complete.

←

List

→

Return

Shaded items are complete.

1	2	3	4	5
6	7	8	9	10
11	12	13	14	15
16	17	18	19	20
21	22	23	24	25
End

Return

See all quizzes of Acute and Chronic Pancreatitis at here:

1. The quantity of pancreatic secretion per day is ?
A. 1000 – 1500 ml
B. 1500 – 3000 ml
C. 3000 – 4500 ml
D. About 5000 ml
2. The pancreatic secretion contain about ?
A. 10 enzymes and zymogens
B. 20 enzymes and zymogens
C. 30 enzymes and zymogens
D. 40 enzymes and zymogens
3. The pancreatic secretion is ?
A. Isosmotic alkaline
B. Isosmotic acidic
C. Hyposmotic alkaline
D. Hyposmotic acidic

4. Which of the following about secretin is false ?
A. Gastric acid is a stimulus for release of secretin
B. Secretin is a peptide with 27 amino acids
C. pH threshold for release of secretin from duodenum &
jejunum is 6.5
D. Secretin stimulates secretion of pancreatic juice rich in water
& electrolytes
5. Which of the following about cholecystokinin (CCK) is false ?
A. CCK evokes an enzyme-rich secretion from pancreas
B. Release of CCK is triggered by short-chain fatty acids
C. Release of CCK is triggered by essential amino acids
D. Release of CCK is triggered by gastric acid

6. Which of the following statements is false ?
A. Bile salts stimulate pancreatic secretion

B. Parasympathetic nervous system exerts significant control
over pancreatic secretion
C. Vasoactive intestinal peptide (VIP) is a CCK agonist
D. H2O and HCO3- secretion by pancreas is dependent
secretin and CCK

7. The quantity of bicarbonate from pancreas needed to neutralize
gastric acid is ?
A. 20 to 30 mmol/day
B. 50 to 100 mmol/day
C. 120 to 300 mmol/day
D. About 500 mmol/day
8. In acini and in ducts, which hormone causes the cells to add
water and bicarbonate to pancreatic fluid ?
A. Insulin
B. Secretin
C. Somatostatin
D. Gastrin

9. Pancreatic exocrine secretion is influenced by ?
A. Somatostatin
B. Neuropeptide Y
C. Calcitonin gene – related peptides
D. All of the above

10. Which of the following correlates best between stimulation with
secretin and the pancreatic mass ?
A. Maximal sodium output
B. Maximal chloride output
C. Maximal acid output
D. Maximal bicarbonate output
11. Bicarbonate in pancreatic secretion is related to ?
A. Insulin
B. Glucagon
C. Cystic fibrosis transmembrane conductance regulator
D. All of the above

12. Pancreas secretes which of the following enzymes ?
A. Amylolytic
B. Lipolytic

C. Proteolytic
D. All of the above

13. The lipolytic enzymes secreted by pancreas are ?
A. Lipase
B. Phospholipase A
C. Cholesterol esterase
D. All of the above

14.Which of the following about bile salts is false ?
A. Inhibit lipase in isolation
B. Colipase binds to lipase & prevents inhibition by bile salts
C. Activate phospholipase A and cholesterol esterase
D. None of the above

15.Which of the following statements is false ?
A. Bile salts inhibit lipase
B. Colipase binds to lipase
C. Bile salts activate phospholipase A & cholesterol esterase
D. None of the above

16. Proteolytic enzymes secreted as inactive precursors are
called ?
A. Zymogens
B. Proteogens
C. Amylogens
D. Chymogens

17. Enzyme that cleaves lysine-isoleucine bond of trypsinogen to
form trypsin is ?
A. Duodenokinase
B. Enterokinase
C. Gastrokinase
D. Trypsokinase
18. Bond that is cleaved to form trypsin from trypsinogen is ?
Harrison’s 18th Ed. 2634
A. Lysine-isoleucine bond
B. Arginine-Threonine bond
C. Arginine-Lysine bond
D. Threonine-Lysine bond

19. Enzyme enterokinase is found in ?
A. Gastric mucosa
B. Duodenal mucosa
C. Jejunal mucosa
D. Ileal mucosa

20. Which of the following can lyse and inactivate trypsin ?
A. Mesotrypsin
B. Chymotrypsin c
C. Enzyme y
D. All of the above

21. Protease inhibitors are found in ?
A. Pancreatic acinar cells
B. Pancreatic secretions
C. Alpha1- and alpha2-globulin fractions of plasma
D. All of the above

22. Kazal type 1 (SPINK1) is best related to ?
A. Pancreatic hyperstimulation
B. Alcohol abuse
C. Anti-inflammatory cytokine
D. Serine protease inhibitor

23. SPINK1 is synthesised in ?
A. Gall bladder
B. Duodenum
C. Stomach
D. Pancreas

24. Which of the following is not a type of trypsinogen in human
pancreatic juice ?
A. Telotrypsinogen
B. Cationic trypsinogen
C. Anionic trypsinogen
D. Mesotrypsinogen

25. Which of the following is the most common PRSS1 mutation ?
A. R122A
B. R122C
C. R122H
D. R122K

Acute and Chronic Pancreatitis- Part 1

[MCQ] Acute and Chronic Pancreatitis- Part 1

I. Start the exam by click the “Start” button

Acute and Chronic Pancreatitis- Part 1

Share this:

Related

[MCQ] Approach to the Patient with Pancreatic Disease

[MCQ] Acute and Chronic Pancreatitis- Part 2

You may also like

Leave a Comment Cancel Reply